Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection
Sleep health and its adaptation to individual and environmental factors are crucial to promote physical and mental well-being across animal species. In recent years, increasing evidence has been reported regarding the relationship between sleep and the immune system and how sleep disturbances may pe...
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| Veröffentlicht in: | International journal of environmental research and public health 2022-01, Vol.19 (2), p.904 |
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| container_title | International journal of environmental research and public health |
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| creator | Ragnoli, Beatrice Pochetti, Patrizia Pignatti, Patrizia Barbieri, Mariangela Mondini, Lucrezia Ruggero, Luca Trotta, Liliana Montuschi, Paolo Malerba, Mario |
| description | Sleep health and its adaptation to individual and environmental factors are crucial to promote physical and mental well-being across animal species. In recent years, increasing evidence has been reported regarding the relationship between sleep and the immune system and how sleep disturbances may perturb the delicate balance with severe repercussions on health outcomes. For instance, experimental sleep deprivation studies in vivo have reported several major detrimental effects on immune health, including induced failure of host defense in rats and increased risk for metabolic syndrome (MetS) and immune suppression in humans. In addition, two novel risk factors for dysregulated metabolic physiology have recently been identified: sleep disruption and circadian misalignment. In light of these recent findings about the interplay between sleep and the immune system, in this review, we focus on the relationship between sleep deprivation and immunity against viruses, with a special interest in SARS-CoV-2 infection. |
| doi_str_mv | 10.3390/ijerph19020904 |
| format | Article |
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In recent years, increasing evidence has been reported regarding the relationship between sleep and the immune system and how sleep disturbances may perturb the delicate balance with severe repercussions on health outcomes. For instance, experimental sleep deprivation studies in vivo have reported several major detrimental effects on immune health, including induced failure of host defense in rats and increased risk for metabolic syndrome (MetS) and immune suppression in humans. In addition, two novel risk factors for dysregulated metabolic physiology have recently been identified: sleep disruption and circadian misalignment. In light of these recent findings about the interplay between sleep and the immune system, in this review, we focus on the relationship between sleep deprivation and immunity against viruses, with a special interest in SARS-CoV-2 infection.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph19020904</identifier><identifier>PMID: 35055726</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animal species ; Animals ; Circadian rhythms ; COVID-19 ; Environmental factors ; Humans ; Immune System ; In vivo methods and tests ; Infections ; Mammals ; Memory ; Metabolic disorders ; Metabolic syndrome ; Metabolism ; Misalignment ; Pathogens ; Physiology ; Rats ; Review ; Risk analysis ; Risk factors ; SARS-CoV-2 ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Sleep ; Sleep Deprivation ; Sleep disorders ; Viruses ; Well being</subject><ispartof>International journal of environmental research and public health, 2022-01, Vol.19 (2), p.904</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | Animal species Animals Circadian rhythms COVID-19 Environmental factors Humans Immune System In vivo methods and tests Infections Mammals Memory Metabolic disorders Metabolic syndrome Metabolism Misalignment Pathogens Physiology Rats Review Risk analysis Risk factors SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Sleep Sleep Deprivation Sleep disorders Viruses Well being |
| title | Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection |
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