Single-Cell Analysis of Aneurysmal Aortic Tissue in Patients with Marfan Syndrome Reveals Dysfunctional TGF-β Signaling

The molecular and cellular processes leading to aortic aneurysm development in Marfan syndrome (MFS) remain poorly understood. In this study, we examined the changes of aortic cell populations and gene expression in MFS by performing single-cell RNA sequencing (scRNA seq) on ascending aortic aneurys...

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Veröffentlicht in:	Genes 2021-12, Vol.13 (1), p.95
Hauptverfasser:	Dawson, Ashley, Li, Yanming, Li, Yang, Ren, Pingping, Vasquez, Hernan G, Zhang, Chen, Rebello, Kimberly R, Ageedi, Waleed, Azares, Alon R, Mattar, Aladdein Burchett, Sheppard, Mary Burchett, Lu, Hong S, Coselli, Joseph S, Cassis, Lisa A, Daugherty, Alan, Shen, Ying H, LeMaire, Scott A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies Aortic Aneurysm, Thoracic - diagnosis Aortic Aneurysm, Thoracic - etiology Aortic Aneurysm, Thoracic - metabolism Aortic aneurysms Case-Control Studies Cell Differentiation Collagen (type I) Correlation analysis Endothelial cells Female Fibroblasts Gene expression Gene Expression Regulation Genomes Genomics Homeostasis Humans Localization Male Marfan syndrome Marfan Syndrome - complications Microscopy Mutation Quality control Quorum sensing Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - metabolism Signal Transduction Single-Cell Analysis Smad protein Smooth muscle Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming growth factor-b Transforming growth factor-b1 Young Adult
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