A Sonic Hedgehog-Gli-Bmi1 signaling pathway plays a critical role in p27 deficiency induced bone anabolism

To explore the mechanism of the bone anabolic action of p27 deficiency, we first confirmed that osteoblast formation and osteogenesis were significantly increased in p27 deficient mice compared with their wild-type littermates. Microarray analysis of differential gene expression profiles, followed b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of biological sciences 2022, Vol.18 (3), p.956-969
Hauptverfasser:	Wu, Jun, Wang, Rong, Kan, Xuechun, Zhang, Jinghan, Sun, Wen, Goltzman, David, Miao, Dengshun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical materials Bone growth Bone marrow Cell cycle Chromatin Cyclin-dependent kinases DNA microarrays Gene expression Hedgehog protein Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Immunoprecipitation In vivo methods and tests Inactivation Kinases Mesenchymal Stem Cells - metabolism Mesenchyme Mice Osteoblasts Osteoblasts - metabolism Osteogenesis Osteogenesis - genetics Osteoporosis Plasmids Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Polymerase chain reaction Proteins Proto-Oncogene Proteins - metabolism Reagents Research Paper Senescence Signal transduction Signal Transduction - genetics Signaling Stem cell transplantation Stem cells Therapeutic targets Transcription Western blotting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!