Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway

Laryngopharyngeal reflux disease (LPRD) is caused by pharyngeal mucosal damage due to the reflux of gastric contents, including acid, pepsin, and bile juice. Our previous study has demonstrated that LPRD is associated with the cleavage of E-cadherin, which is facilitated by the acid-activated matrix...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2022-02, Vol.100 (2), p.313-322
Hauptverfasser:	Im, Nu-Ri, Kim, Byoungjae, Jung, Kwang-Yoon, Baek, Seung-Kuk
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adult Antigens, CD - genetics Antigens, CD - metabolism Biomedical and Life Sciences Biomedicine c-Jun protein Cadherins - genetics Cadherins - metabolism Cells, Cultured E-cadherin Epithelial cells Epithelial Cells - metabolism Extracellular signal-regulated kinase Female Human Genetics Humans Hydrochloric Acid Internal Medicine JNK Mitogen-Activated Protein Kinases - metabolism Kinases Male MAP kinase MAP Kinase Signaling System Matrilysin Matrix metalloproteinase Matrix Metalloproteinase 7 - genetics Matrix Metalloproteinase 7 - metabolism Membrane permeability Metabolic pathways Metalloproteinase Middle Aged Molecular Medicine Mucosa Original Original Article Pepsin Permeability Pharynx Pharynx - cytology Protein kinase Reactive oxygen species Reactive Oxygen Species - metabolism Signal transduction Transcription factors Young Adult
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