Can biochemical pregnancy be determined 5 days after frozen-thawed embryo transfer?
To study the predictive value of serum β-hCG on day 5 after frozen-thawed embryo transfer (FET) to predict pregnancy outcomes and to establish cut-off values for very early biochemical pregnancy diagnosis. This retrospective cohort study was performed at a private reproductive medicine centre and we...
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| Veröffentlicht in: | JBRA assisted reproduction 2022-01, Vol.26 (1), p.62-67 |
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| creator | Yadid, Isaac M Criscuolo, Thelma S Santos, Jéssica F Giordano, Luiz A |
| description | To study the predictive value of serum β-hCG on day 5 after frozen-thawed embryo transfer (FET) to predict pregnancy outcomes and to establish cut-off values for very early biochemical pregnancy diagnosis.
This retrospective cohort study was performed at a private reproductive medicine centre and we reviewed the medical records of women who underwent FET cycles from January 2018 to June 2019. A total of 116 evaluated cycles had serum β-hCG levels measured on days 5 and 10 after FET. The predictive value of serum β-hCG levels measured on day 5 after FET was investigated for very early biochemical pregnancy diagnosis.
The standard biochemical pregnancy diagnosis was defined as a β-hCG ≥25 IU/L on day 10 after FET. We then generated a receiver operating characteristic curve, and the cut-off value of β-hCG on day 5 for predicting biochemical pregnancies was 4.0 IU/L, with 93.4% sensitivity and 92.7% specificity (AUC, 0.960; 95% confidence interval, 0.923-0.997).
Values for β-hCG at day 5 after FET ≥4.0IU/L are accurate for the diagnosis of biochemical pregnancy. The use of very early biochemical pregnancy diagnosis in clinical practice enables earlier management, patient counselling, and appropriate follow-up. |
| doi_str_mv | 10.5935/1518-0557.20210054 |
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This retrospective cohort study was performed at a private reproductive medicine centre and we reviewed the medical records of women who underwent FET cycles from January 2018 to June 2019. A total of 116 evaluated cycles had serum β-hCG levels measured on days 5 and 10 after FET. The predictive value of serum β-hCG levels measured on day 5 after FET was investigated for very early biochemical pregnancy diagnosis.
The standard biochemical pregnancy diagnosis was defined as a β-hCG ≥25 IU/L on day 10 after FET. We then generated a receiver operating characteristic curve, and the cut-off value of β-hCG on day 5 for predicting biochemical pregnancies was 4.0 IU/L, with 93.4% sensitivity and 92.7% specificity (AUC, 0.960; 95% confidence interval, 0.923-0.997).
Values for β-hCG at day 5 after FET ≥4.0IU/L are accurate for the diagnosis of biochemical pregnancy. The use of very early biochemical pregnancy diagnosis in clinical practice enables earlier management, patient counselling, and appropriate follow-up.</description><identifier>ISSN: 1518-0557</identifier><identifier>ISSN: 1517-5693</identifier><identifier>EISSN: 1518-0557</identifier><identifier>DOI: 10.5935/1518-0557.20210054</identifier><identifier>PMID: 34415123</identifier><language>eng</language><publisher>Brazil: Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</publisher><subject>Chorionic Gonadotropin, beta Subunit, Human ; Embryo Transfer ; Embryos ; Female ; Humans ; In vitro fertilization ; Medical records ; Original ; Ovaries ; Patients ; Pregnancy ; Pregnancy Complications ; Pregnancy Outcome ; Reproductive health ; Retrospective Studies ; Urine</subject><ispartof>JBRA assisted reproduction, 2022-01, Vol.26 (1), p.62-67</ispartof><rights>2022. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-653917ed2491113cfdc5c88c75eee2b60a4f017f38aa46ccf90cd0a52dab84f43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769177/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769177/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34415123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yadid, Isaac M</creatorcontrib><creatorcontrib>Criscuolo, Thelma S</creatorcontrib><creatorcontrib>Santos, Jéssica F</creatorcontrib><creatorcontrib>Giordano, Luiz A</creatorcontrib><title>Can biochemical pregnancy be determined 5 days after frozen-thawed embryo transfer?</title><title>JBRA assisted reproduction</title><addtitle>JBRA Assist Reprod</addtitle><description>To study the predictive value of serum β-hCG on day 5 after frozen-thawed embryo transfer (FET) to predict pregnancy outcomes and to establish cut-off values for very early biochemical pregnancy diagnosis.
This retrospective cohort study was performed at a private reproductive medicine centre and we reviewed the medical records of women who underwent FET cycles from January 2018 to June 2019. A total of 116 evaluated cycles had serum β-hCG levels measured on days 5 and 10 after FET. The predictive value of serum β-hCG levels measured on day 5 after FET was investigated for very early biochemical pregnancy diagnosis.
The standard biochemical pregnancy diagnosis was defined as a β-hCG ≥25 IU/L on day 10 after FET. We then generated a receiver operating characteristic curve, and the cut-off value of β-hCG on day 5 for predicting biochemical pregnancies was 4.0 IU/L, with 93.4% sensitivity and 92.7% specificity (AUC, 0.960; 95% confidence interval, 0.923-0.997).
Values for β-hCG at day 5 after FET ≥4.0IU/L are accurate for the diagnosis of biochemical pregnancy. The use of very early biochemical pregnancy diagnosis in clinical practice enables earlier management, patient counselling, and appropriate follow-up.</description><subject>Chorionic Gonadotropin, beta Subunit, Human</subject><subject>Embryo Transfer</subject><subject>Embryos</subject><subject>Female</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Medical records</subject><subject>Original</subject><subject>Ovaries</subject><subject>Patients</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Pregnancy Outcome</subject><subject>Reproductive health</subject><subject>Retrospective Studies</subject><subject>Urine</subject><issn>1518-0557</issn><issn>1517-5693</issn><issn>1518-0557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpVUU1LAzEQDaLYUvsHPEjA89Z87sdFkeIXFDyo55DNTtot3WxNtsr6601pLfU0w7yZ9x5vELqkZCILLm-opHlCpMwmjDBKiBQnaHgYnh71AzQOYUkIoQVlXJBzNOBCRJjxIXqbaofLujULaGqjV3jtYe60Mz0uAVfQgW9qBxWWuNJ9wNrGCba-_QGXdAv9HSFoSt-3uPPaBQv-7gKdWb0KMN7XEfp4fHifPiez16eX6f0sMYKTLkklL2gGFRMFpZQbWxlp8txkEgBYmRItLKGZ5bnWIjXGFsRUREtW6TIXVvARut3xrjdlA5UBFy2s1NrXjfa9anWt_iOuXqh5-6XyLI3KWSS43hP49nMDoVPLduNd9KxYylghpeB53GK7LePbEDzYgwIlavsLtY1abaNWf7-IR1fH3g4nf8nzX220hT8</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Yadid, Isaac M</creator><creator>Criscuolo, Thelma S</creator><creator>Santos, Jéssica F</creator><creator>Giordano, Luiz A</creator><general>Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</general><general>Brazilian Society of Assisted Reproduction</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20220101</creationdate><title>Can biochemical pregnancy be determined 5 days after frozen-thawed embryo transfer?</title><author>Yadid, Isaac M ; Criscuolo, Thelma S ; Santos, Jéssica F ; Giordano, Luiz A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-653917ed2491113cfdc5c88c75eee2b60a4f017f38aa46ccf90cd0a52dab84f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Chorionic Gonadotropin, beta Subunit, Human</topic><topic>Embryo Transfer</topic><topic>Embryos</topic><topic>Female</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Medical records</topic><topic>Original</topic><topic>Ovaries</topic><topic>Patients</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Pregnancy Outcome</topic><topic>Reproductive health</topic><topic>Retrospective Studies</topic><topic>Urine</topic><toplevel>online_resources</toplevel><creatorcontrib>Yadid, Isaac M</creatorcontrib><creatorcontrib>Criscuolo, Thelma S</creatorcontrib><creatorcontrib>Santos, Jéssica F</creatorcontrib><creatorcontrib>Giordano, Luiz A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JBRA assisted reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yadid, Isaac M</au><au>Criscuolo, Thelma S</au><au>Santos, Jéssica F</au><au>Giordano, Luiz A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can biochemical pregnancy be determined 5 days after frozen-thawed embryo transfer?</atitle><jtitle>JBRA assisted reproduction</jtitle><addtitle>JBRA Assist Reprod</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>26</volume><issue>1</issue><spage>62</spage><epage>67</epage><pages>62-67</pages><issn>1518-0557</issn><issn>1517-5693</issn><eissn>1518-0557</eissn><abstract>To study the predictive value of serum β-hCG on day 5 after frozen-thawed embryo transfer (FET) to predict pregnancy outcomes and to establish cut-off values for very early biochemical pregnancy diagnosis.
This retrospective cohort study was performed at a private reproductive medicine centre and we reviewed the medical records of women who underwent FET cycles from January 2018 to June 2019. A total of 116 evaluated cycles had serum β-hCG levels measured on days 5 and 10 after FET. The predictive value of serum β-hCG levels measured on day 5 after FET was investigated for very early biochemical pregnancy diagnosis.
The standard biochemical pregnancy diagnosis was defined as a β-hCG ≥25 IU/L on day 10 after FET. We then generated a receiver operating characteristic curve, and the cut-off value of β-hCG on day 5 for predicting biochemical pregnancies was 4.0 IU/L, with 93.4% sensitivity and 92.7% specificity (AUC, 0.960; 95% confidence interval, 0.923-0.997).
Values for β-hCG at day 5 after FET ≥4.0IU/L are accurate for the diagnosis of biochemical pregnancy. The use of very early biochemical pregnancy diagnosis in clinical practice enables earlier management, patient counselling, and appropriate follow-up.</abstract><cop>Brazil</cop><pub>Sociedade Brasileira de Reprodução Humana (Brazilian Society of Assisted Reproduction)</pub><pmid>34415123</pmid><doi>10.5935/1518-0557.20210054</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Chorionic Gonadotropin, beta Subunit, Human Embryo Transfer Embryos Female Humans In vitro fertilization Medical records Original Ovaries Patients Pregnancy Pregnancy Complications Pregnancy Outcome Reproductive health Retrospective Studies Urine |
| title | Can biochemical pregnancy be determined 5 days after frozen-thawed embryo transfer? |
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