Supply chain logistics - the role of the Golgi complex in extracellular matrix production and maintenance
The biomechanical and biochemical properties of connective tissues are determined by the composition and quality of their extracellular matrix. This, in turn, is highly dependent on the function and organisation of the secretory pathway. The Golgi complex plays a vital role in directing matrix outpu...
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| Veröffentlicht in: | Journal of cell science 2022-01, Vol.135 (1) |
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| container_title | Journal of cell science |
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| creator | Hellicar, John Stevenson, Nicola L Stephens, David J Lowe, Martin |
| description | The biomechanical and biochemical properties of connective tissues are determined by the composition and quality of their extracellular matrix. This, in turn, is highly dependent on the function and organisation of the secretory pathway. The Golgi complex plays a vital role in directing matrix output by co-ordinating the post-translational modification and proteolytic processing of matrix components prior to their secretion. These modifications have broad impacts on the secretion and subsequent assembly of matrix components, as well as their function in the extracellular environment. In this Review, we highlight the role of the Golgi in the formation of an adaptable, healthy matrix, with a focus on proteoglycan and procollagen secretion as example cargoes. We then discuss the impact of Golgi dysfunction on connective tissue in the context of human disease and ageing. |
| doi_str_mv | 10.1242/jcs.258879 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0021-9533 |
| ispartof | Journal of cell science, 2022-01, Vol.135 (1) |
| issn | 0021-9533 1477-9137 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8767278 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Cell biology and disease ESCRT machinery Extracellular Matrix - metabolism Golgi Apparatus Humans Proteoglycans - genetics Proteoglycans - metabolism Review Secretory Pathway |
| title | Supply chain logistics - the role of the Golgi complex in extracellular matrix production and maintenance |
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