Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica
Nephropathia epidemica (NE) is a zoonotic disease caused by hantaviruses transmitted from rodents, endemic in the Republic of Tatarstan, Russia. The disease presents clinically with mild, moderate, and severe forms, and time-dependent febrile, oliguric, and polyuric stages of the disease are also re...
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| creator | Shakirova, Venera Khaertynova, Ilseyar Markelova, Maria Tarlinton, Rachael Behnke, Jerzy Martynova, Ekaterina Garanina, Ekaterina Rizvanov, Albert Khaiboullina, Svetlana |
| description | Nephropathia epidemica (NE) is a zoonotic disease caused by hantaviruses transmitted from rodents, endemic in the Republic of Tatarstan, Russia. The disease presents clinically with mild, moderate, and severe forms, and time-dependent febrile, oliguric, and polyuric stages of the disease are also recognized. The patient’s cytokine responses have been suggested to play a central role in disease pathogenesis; however, little is known about the different patterns of cytokine expression in NE in cohorts of different ages and sexes. Serum samples and clinical records were collected from 139 patients and 57 controls (healthy donors) and were used to analyze 48 analytes with the Bio-Plex multiplex magnetic bead-based antibody detection kits. Principal component analysis of 137 patient and 55 controls (for which there was full data) identified two components that individually accounted for >15% of the total variance in results and together for 38% of the total variance. PC1 represented a proinflammatory TH17/TH2 cell antiviral cytokine profile and PC2 a more antiviral cytokine profile with patients tending to display one or the other of these. Severity of disease and stage of illness did not show any correlation with PC1 profiles; however, significant differences were seen in patients with high PC1 profiles vs. lower for a number of individual clinical parameters: High PC1 patients showed a reduced number of febrile days, but higher maximum urine output, higher creatinine levels, and lower platelet levels. Overall, the results of this study point towards a stronger proinflammatory profile occurring in younger NE patients, this being associated with markers of acute kidney injury and low levels of high-density cholesterol. This is consistent with previous work indicating that the pathology of NE is immune driven, with an inflammatory immune response being associated with disease and that this immune response is more extreme in younger patients. |
| doi_str_mv | 10.1155/2022/4685288 |
| format | Article |
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C. ; Washington L C dos Santos</contributor><creatorcontrib>Shakirova, Venera ; Khaertynova, Ilseyar ; Markelova, Maria ; Tarlinton, Rachael ; Behnke, Jerzy ; Martynova, Ekaterina ; Garanina, Ekaterina ; Rizvanov, Albert ; Khaiboullina, Svetlana ; dos Santos, Washington L. C. ; Washington L C dos Santos</creatorcontrib><description>Nephropathia epidemica (NE) is a zoonotic disease caused by hantaviruses transmitted from rodents, endemic in the Republic of Tatarstan, Russia. The disease presents clinically with mild, moderate, and severe forms, and time-dependent febrile, oliguric, and polyuric stages of the disease are also recognized. The patient’s cytokine responses have been suggested to play a central role in disease pathogenesis; however, little is known about the different patterns of cytokine expression in NE in cohorts of different ages and sexes. Serum samples and clinical records were collected from 139 patients and 57 controls (healthy donors) and were used to analyze 48 analytes with the Bio-Plex multiplex magnetic bead-based antibody detection kits. Principal component analysis of 137 patient and 55 controls (for which there was full data) identified two components that individually accounted for >15% of the total variance in results and together for 38% of the total variance. PC1 represented a proinflammatory TH17/TH2 cell antiviral cytokine profile and PC2 a more antiviral cytokine profile with patients tending to display one or the other of these. Severity of disease and stage of illness did not show any correlation with PC1 profiles; however, significant differences were seen in patients with high PC1 profiles vs. lower for a number of individual clinical parameters: High PC1 patients showed a reduced number of febrile days, but higher maximum urine output, higher creatinine levels, and lower platelet levels. Overall, the results of this study point towards a stronger proinflammatory profile occurring in younger NE patients, this being associated with markers of acute kidney injury and low levels of high-density cholesterol. This is consistent with previous work indicating that the pathology of NE is immune driven, with an inflammatory immune response being associated with disease and that this immune response is more extreme in younger patients.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2022/4685288</identifier><identifier>PMID: 35059462</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Acute Kidney Injury - blood ; Acute Kidney Injury - immunology ; Adult ; Antibodies ; Biomarkers - blood ; Biomedical research ; Cholesterol ; Creatinine ; Cytokines ; Cytokines - blood ; Cytokines - immunology ; Disease transmission ; Ethics ; Female ; Fever ; Generalized linear models ; Headaches ; Helper cells ; Hemorrhagic Fever with Renal Syndrome - blood ; Hemorrhagic Fever with Renal Syndrome - immunology ; Humans ; Hypotheses ; Immune response ; Immune system ; Inflammation ; Kidneys ; Laboratories ; Lymphocytes T ; Male ; Males ; Middle Aged ; Pathogenesis ; Pathology ; Patients ; Principal components analysis ; Software ; Statistical analysis ; Tatarstan ; Th17 Cells - immunology ; Th17 Cells - metabolism ; Th2 Cells - immunology ; Th2 Cells - metabolism ; Zoonoses</subject><ispartof>BioMed research international, 2022, Vol.2022 (1), p.4685288-4685288</ispartof><rights>Copyright © 2022 Venera Shakirova et al.</rights><rights>Copyright © 2022 Venera Shakirova et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Venera Shakirova et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-bd34cde736cba1fb9c702d40bf3f497c2382fdf5a64f95e1236e17ee8f92d90b3</citedby><cites>FETCH-LOGICAL-c448t-bd34cde736cba1fb9c702d40bf3f497c2382fdf5a64f95e1236e17ee8f92d90b3</cites><orcidid>0000-0003-1537-3099 ; 0000-0002-5064-570X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766188/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766188/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35059462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>dos Santos, Washington L. C.</contributor><contributor>Washington L C dos Santos</contributor><creatorcontrib>Shakirova, Venera</creatorcontrib><creatorcontrib>Khaertynova, Ilseyar</creatorcontrib><creatorcontrib>Markelova, Maria</creatorcontrib><creatorcontrib>Tarlinton, Rachael</creatorcontrib><creatorcontrib>Behnke, Jerzy</creatorcontrib><creatorcontrib>Martynova, Ekaterina</creatorcontrib><creatorcontrib>Garanina, Ekaterina</creatorcontrib><creatorcontrib>Rizvanov, Albert</creatorcontrib><creatorcontrib>Khaiboullina, Svetlana</creatorcontrib><title>Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Nephropathia epidemica (NE) is a zoonotic disease caused by hantaviruses transmitted from rodents, endemic in the Republic of Tatarstan, Russia. The disease presents clinically with mild, moderate, and severe forms, and time-dependent febrile, oliguric, and polyuric stages of the disease are also recognized. The patient’s cytokine responses have been suggested to play a central role in disease pathogenesis; however, little is known about the different patterns of cytokine expression in NE in cohorts of different ages and sexes. Serum samples and clinical records were collected from 139 patients and 57 controls (healthy donors) and were used to analyze 48 analytes with the Bio-Plex multiplex magnetic bead-based antibody detection kits. Principal component analysis of 137 patient and 55 controls (for which there was full data) identified two components that individually accounted for >15% of the total variance in results and together for 38% of the total variance. PC1 represented a proinflammatory TH17/TH2 cell antiviral cytokine profile and PC2 a more antiviral cytokine profile with patients tending to display one or the other of these. Severity of disease and stage of illness did not show any correlation with PC1 profiles; however, significant differences were seen in patients with high PC1 profiles vs. lower for a number of individual clinical parameters: High PC1 patients showed a reduced number of febrile days, but higher maximum urine output, higher creatinine levels, and lower platelet levels. Overall, the results of this study point towards a stronger proinflammatory profile occurring in younger NE patients, this being associated with markers of acute kidney injury and low levels of high-density cholesterol. 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C.</au><au>Washington L C dos Santos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><issue>1</issue><spage>4685288</spage><epage>4685288</epage><pages>4685288-4685288</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Nephropathia epidemica (NE) is a zoonotic disease caused by hantaviruses transmitted from rodents, endemic in the Republic of Tatarstan, Russia. The disease presents clinically with mild, moderate, and severe forms, and time-dependent febrile, oliguric, and polyuric stages of the disease are also recognized. The patient’s cytokine responses have been suggested to play a central role in disease pathogenesis; however, little is known about the different patterns of cytokine expression in NE in cohorts of different ages and sexes. Serum samples and clinical records were collected from 139 patients and 57 controls (healthy donors) and were used to analyze 48 analytes with the Bio-Plex multiplex magnetic bead-based antibody detection kits. Principal component analysis of 137 patient and 55 controls (for which there was full data) identified two components that individually accounted for >15% of the total variance in results and together for 38% of the total variance. PC1 represented a proinflammatory TH17/TH2 cell antiviral cytokine profile and PC2 a more antiviral cytokine profile with patients tending to display one or the other of these. Severity of disease and stage of illness did not show any correlation with PC1 profiles; however, significant differences were seen in patients with high PC1 profiles vs. lower for a number of individual clinical parameters: High PC1 patients showed a reduced number of febrile days, but higher maximum urine output, higher creatinine levels, and lower platelet levels. Overall, the results of this study point towards a stronger proinflammatory profile occurring in younger NE patients, this being associated with markers of acute kidney injury and low levels of high-density cholesterol. This is consistent with previous work indicating that the pathology of NE is immune driven, with an inflammatory immune response being associated with disease and that this immune response is more extreme in younger patients.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35059462</pmid><doi>10.1155/2022/4685288</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-1537-3099</orcidid><orcidid>https://orcid.org/0000-0002-5064-570X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Kidney Injury - blood Acute Kidney Injury - immunology Adult Antibodies Biomarkers - blood Biomedical research Cholesterol Creatinine Cytokines Cytokines - blood Cytokines - immunology Disease transmission Ethics Female Fever Generalized linear models Headaches Helper cells Hemorrhagic Fever with Renal Syndrome - blood Hemorrhagic Fever with Renal Syndrome - immunology Humans Hypotheses Immune response Immune system Inflammation Kidneys Laboratories Lymphocytes T Male Males Middle Aged Pathogenesis Pathology Patients Principal components analysis Software Statistical analysis Tatarstan Th17 Cells - immunology Th17 Cells - metabolism Th2 Cells - immunology Th2 Cells - metabolism Zoonoses |
| title | Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica |
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