Infliximab-Associated Xanthogranulomatous Pyelonephritis: A Rare Complication
Xanthogranulomatous pyelonephritis (XGP) is one of the rare diseases characterized by chronic inflammation and destruction of the renal parenchyma, and it is usually associated with renal infection, and nephrolithiasis. Infliximab is an anti-tumor necrosis factor-alpha (anti-TNF-α) monoclonal antibo...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2022-01, Vol.14 (1), p.e21051 |
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| container_title | Curēus (Palo Alto, CA) |
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| creator | Alzanbagi, Adnan Alhazmi, Ghadeer A Alghamdi, Shuruq Alosaimi, Ghaida Shariff, Mohammed K |
| description | Xanthogranulomatous pyelonephritis (XGP) is one of the rare diseases characterized by chronic inflammation and destruction of the renal parenchyma, and it is usually associated with renal infection, and nephrolithiasis. Infliximab is an anti-tumor necrosis factor-alpha (anti-TNF-α) monoclonal antibody, which is widely used for treating inflammatory bowel disease, and it is known to increase the risk of rare and opportunistic infections. In this study, we report a case of XGP presenting after the initiation of infliximab treatment. We highlight one of the possible complications associated with immunosuppression due to infliximab. Furthermore, the importance of increasing the awareness among physicians for early recognition of this rare complication. |
| doi_str_mv | 10.7759/cureus.21051 |
| format | Article |
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Infliximab is an anti-tumor necrosis factor-alpha (anti-TNF-α) monoclonal antibody, which is widely used for treating inflammatory bowel disease, and it is known to increase the risk of rare and opportunistic infections. In this study, we report a case of XGP presenting after the initiation of infliximab treatment. We highlight one of the possible complications associated with immunosuppression due to infliximab. 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| subjects | Abdomen Case reports Cytomegalovirus Gastroenterology Inflammatory diseases Kidney diseases Monoclonal antibodies Rare diseases TNF inhibitors Tuberculosis Tumor necrosis factor-TNF |
| title | Infliximab-Associated Xanthogranulomatous Pyelonephritis: A Rare Complication |
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