Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML

Eukaryotic initiation factor 4A (eIF4A), the enzymatic core of the eIF4F complex essential for translation initiation, plays a key role in the oncogenic reprogramming of protein synthesis, and thus is a putative therapeutic target in cancer. As important component of its anticancer activity, inhibit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2021-09, Vol.35 (9), p.2469-2481
Hauptverfasser:	Nishida, Yuki, Zhao, Ran, Heese, Lauren E., Akiyama, Hiroki, Patel, Shreya, Jaeger, Alex M., Jacamo, Rodrigo O., Kojima, Kensuke, Ma, Man Chun John, Ruvolo, Vivian R., Chachad, Dhruv, Devine, William, Lindquist, Susan, Davis, R. Eric, Porco, John A., Whitesell, Luke, Andreeff, Michael, Ishizawa, Jo
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/100 13/106 13/2 13/31 38/47 42/34 45/77 631/67/71 631/80/82 64/60 692/699/1541/1990 Acute myeloid leukemia Animals Anticancer properties Antineoplastic Agents - pharmacology Antitumor activity Cancer Cancer Research Cell survival Critical Care Medicine Eukaryotic Initiation Factor-4A - antagonists & inhibitors Gene mutations Health aspects Heat shock Heat shock factors Heat Shock Transcription Factors - antagonists & inhibitors Hematology HSF1 protein Humans Inhibitors Initiation factor eIF-4A Innovations Intensive Internal Medicine Kinases Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - pathology Medicine Medicine & Public Health Molecular Targeted Therapy Mutants Mutation Myeloid leukemia Oncology Protein biosynthesis Protein synthesis Protein-tyrosine kinase Review Article Therapeutic targets Transcription factors Tyrosine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!