Severe Acute Respiratory Syndrome Coronavirus 2 RNAemia and Clinical Outcomes in Children With Coronavirus Disease 2019
Abstract The burden of coronavirus disease 2019 (COVID-19) in children represents a fraction of cases worldwide, yet a subset of those infected are at risk for severe disease. We measured plasma severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in a cohort of 103 children hospitalized...
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| Veröffentlicht in: | The Journal of infectious diseases 2022-01, Vol.225 (2), p.208-213 |
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| creator | Mertz, Cameron Glowinski, Rebecca Cohen, Shira H Mertz, Sara Ye, Fang Hall, Mark W Peeples, Mark E King, Tiffany Wang, Huanyu Leber, Amy L Sanchez, Pablo J Ramilo, Octavio Mejias, Asuncion |
| description | Abstract
The burden of coronavirus disease 2019 (COVID-19) in children represents a fraction of cases worldwide, yet a subset of those infected are at risk for severe disease. We measured plasma severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in a cohort of 103 children hospitalized with COVID-19 with diverse clinical manifestations. SARS-CoV-2 RNAemia was detected in 27 (26%) of these children, lasted for a median of 6 (interquartile range, 2–9) days, and was associated with higher rates of oxygen administration, admission to the intensive care unit, and longer hospitalization.
In a cohort of 103 children and adolescents hospitalized with COVID-19 with diverse clinical manifestations, SARS-CoV-2 RNAemia was detected in 26% of them, lasted for 6 (interquartile range, 2–9) days, and was associated with worse clinical outcomes. |
| doi_str_mv | 10.1093/infdis/jiab491 |
| format | Article |
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The burden of coronavirus disease 2019 (COVID-19) in children represents a fraction of cases worldwide, yet a subset of those infected are at risk for severe disease. We measured plasma severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in a cohort of 103 children hospitalized with COVID-19 with diverse clinical manifestations. SARS-CoV-2 RNAemia was detected in 27 (26%) of these children, lasted for a median of 6 (interquartile range, 2–9) days, and was associated with higher rates of oxygen administration, admission to the intensive care unit, and longer hospitalization.
In a cohort of 103 children and adolescents hospitalized with COVID-19 with diverse clinical manifestations, SARS-CoV-2 RNAemia was detected in 26% of them, lasted for 6 (interquartile range, 2–9) days, and was associated with worse clinical outcomes.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiab491</identifier><identifier>PMID: 34618885</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adolescent ; Anemia ; Child ; Child, Preschool ; Children ; Clinical outcomes ; Coronaviruses ; COVID-19 ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; COVID-19 Nucleic Acid Testing - methods ; Female ; Hospitalization ; Humans ; Infant ; Intensive care ; Intensive Care Units ; Major and Brief Reports ; Male ; Nasopharynx - virology ; Oxygen therapy ; Pediatrics ; Ribonucleic acid ; RNA ; RNA, Viral - genetics ; SARS-CoV-2 - genetics ; SARS-CoV-2 - isolation & purification ; Severe acute respiratory syndrome coronavirus 2 ; Severity of Illness Index ; Viremia - epidemiology</subject><ispartof>The Journal of infectious diseases, 2022-01, Vol.225 (2), p.208-213</ispartof><rights>The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-6cf72a4ef7b52b70cfd177b48950ee272b33956224a60712012618e6cb336f523</citedby><cites>FETCH-LOGICAL-c452t-6cf72a4ef7b52b70cfd177b48950ee272b33956224a60712012618e6cb336f523</cites><orcidid>0000-0002-5983-8006</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34618885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mertz, Cameron</creatorcontrib><creatorcontrib>Glowinski, Rebecca</creatorcontrib><creatorcontrib>Cohen, Shira H</creatorcontrib><creatorcontrib>Mertz, Sara</creatorcontrib><creatorcontrib>Ye, Fang</creatorcontrib><creatorcontrib>Hall, Mark W</creatorcontrib><creatorcontrib>Peeples, Mark E</creatorcontrib><creatorcontrib>King, Tiffany</creatorcontrib><creatorcontrib>Wang, Huanyu</creatorcontrib><creatorcontrib>Leber, Amy L</creatorcontrib><creatorcontrib>Sanchez, Pablo J</creatorcontrib><creatorcontrib>Ramilo, Octavio</creatorcontrib><creatorcontrib>Mejias, Asuncion</creatorcontrib><title>Severe Acute Respiratory Syndrome Coronavirus 2 RNAemia and Clinical Outcomes in Children With Coronavirus Disease 2019</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
The burden of coronavirus disease 2019 (COVID-19) in children represents a fraction of cases worldwide, yet a subset of those infected are at risk for severe disease. We measured plasma severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in a cohort of 103 children hospitalized with COVID-19 with diverse clinical manifestations. SARS-CoV-2 RNAemia was detected in 27 (26%) of these children, lasted for a median of 6 (interquartile range, 2–9) days, and was associated with higher rates of oxygen administration, admission to the intensive care unit, and longer hospitalization.
In a cohort of 103 children and adolescents hospitalized with COVID-19 with diverse clinical manifestations, SARS-CoV-2 RNAemia was detected in 26% of them, lasted for 6 (interquartile range, 2–9) days, and was associated with worse clinical outcomes.</description><subject>Adolescent</subject><subject>Anemia</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Clinical outcomes</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 Nucleic Acid Testing - methods</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infant</subject><subject>Intensive care</subject><subject>Intensive Care Units</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Nasopharynx - virology</subject><subject>Oxygen therapy</subject><subject>Pediatrics</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Viral - genetics</subject><subject>SARS-CoV-2 - genetics</subject><subject>SARS-CoV-2 - isolation & purification</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Severity of Illness Index</subject><subject>Viremia - epidemiology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtr3DAURkVpaKZpt10WQTftwokelmRvCoPTF4QEkpYuhSxfdzTY0lSyJ8y_r9KZhqSbrARX5x7ux4fQG0pOKan5mfN959LZ2pm2rOkztKCCq0JKyp-jBSGMFbSq62P0MqU1IaTkUr1Ax7yUtKoqsUC3N7CFCHhp5wnwNaSNi2YKcYdvdr6LYQTchBi82bo4J8zw9eUSRmew8R1uBuedNQO-mieb0YSdx83KDV0Ej3-6afVo-dwlMAkwI7R-hY56MyR4fXhP0I_Pn743X4uLqy_fmuVFYUvBpkLaXjFTQq9awVpFbN9RpdqyqgUBYIq1nNdCMlYaSRTNZpaTgbR5LnvB-An6uPdu5naEzoKfohn0JrrRxJ0OxunHP96t9K-w1ZWSd-YseH8QxPB7hjTp0SULw2A8hDlpJioia1IJktF3_6HrMEef42km8111yf9edLqnbAwpRejvj6FE33Wq953qQ6d54e3DCPf4vxIz8GEPhHnzlOwPaIutpg</recordid><startdate>20220118</startdate><enddate>20220118</enddate><creator>Mertz, Cameron</creator><creator>Glowinski, Rebecca</creator><creator>Cohen, Shira H</creator><creator>Mertz, Sara</creator><creator>Ye, Fang</creator><creator>Hall, Mark W</creator><creator>Peeples, Mark E</creator><creator>King, Tiffany</creator><creator>Wang, Huanyu</creator><creator>Leber, Amy L</creator><creator>Sanchez, Pablo J</creator><creator>Ramilo, Octavio</creator><creator>Mejias, Asuncion</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5983-8006</orcidid></search><sort><creationdate>20220118</creationdate><title>Severe Acute Respiratory Syndrome Coronavirus 2 RNAemia and Clinical Outcomes in Children With Coronavirus Disease 2019</title><author>Mertz, Cameron ; Glowinski, Rebecca ; Cohen, Shira H ; Mertz, Sara ; Ye, Fang ; Hall, Mark W ; Peeples, Mark E ; King, Tiffany ; Wang, Huanyu ; Leber, Amy L ; Sanchez, Pablo J ; Ramilo, Octavio ; Mejias, Asuncion</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-6cf72a4ef7b52b70cfd177b48950ee272b33956224a60712012618e6cb336f523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Anemia</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Clinical outcomes</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - diagnosis</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 Nucleic Acid Testing - methods</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Infant</topic><topic>Intensive care</topic><topic>Intensive Care Units</topic><topic>Major and Brief Reports</topic><topic>Male</topic><topic>Nasopharynx - virology</topic><topic>Oxygen therapy</topic><topic>Pediatrics</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Viral - genetics</topic><topic>SARS-CoV-2 - genetics</topic><topic>SARS-CoV-2 - isolation & purification</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Severity of Illness Index</topic><topic>Viremia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mertz, Cameron</creatorcontrib><creatorcontrib>Glowinski, Rebecca</creatorcontrib><creatorcontrib>Cohen, Shira H</creatorcontrib><creatorcontrib>Mertz, Sara</creatorcontrib><creatorcontrib>Ye, Fang</creatorcontrib><creatorcontrib>Hall, Mark W</creatorcontrib><creatorcontrib>Peeples, Mark E</creatorcontrib><creatorcontrib>King, Tiffany</creatorcontrib><creatorcontrib>Wang, Huanyu</creatorcontrib><creatorcontrib>Leber, Amy L</creatorcontrib><creatorcontrib>Sanchez, Pablo J</creatorcontrib><creatorcontrib>Ramilo, Octavio</creatorcontrib><creatorcontrib>Mejias, Asuncion</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mertz, Cameron</au><au>Glowinski, Rebecca</au><au>Cohen, Shira H</au><au>Mertz, Sara</au><au>Ye, Fang</au><au>Hall, Mark W</au><au>Peeples, Mark E</au><au>King, Tiffany</au><au>Wang, Huanyu</au><au>Leber, Amy L</au><au>Sanchez, Pablo J</au><au>Ramilo, Octavio</au><au>Mejias, Asuncion</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe Acute Respiratory Syndrome Coronavirus 2 RNAemia and Clinical Outcomes in Children With Coronavirus Disease 2019</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2022-01-18</date><risdate>2022</risdate><volume>225</volume><issue>2</issue><spage>208</spage><epage>213</epage><pages>208-213</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
The burden of coronavirus disease 2019 (COVID-19) in children represents a fraction of cases worldwide, yet a subset of those infected are at risk for severe disease. We measured plasma severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in a cohort of 103 children hospitalized with COVID-19 with diverse clinical manifestations. SARS-CoV-2 RNAemia was detected in 27 (26%) of these children, lasted for a median of 6 (interquartile range, 2–9) days, and was associated with higher rates of oxygen administration, admission to the intensive care unit, and longer hospitalization.
In a cohort of 103 children and adolescents hospitalized with COVID-19 with diverse clinical manifestations, SARS-CoV-2 RNAemia was detected in 26% of them, lasted for 6 (interquartile range, 2–9) days, and was associated with worse clinical outcomes.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>34618885</pmid><doi>10.1093/infdis/jiab491</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5983-8006</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2022-01, Vol.225 (2), p.208-213 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adolescent Anemia Child Child, Preschool Children Clinical outcomes Coronaviruses COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 Nucleic Acid Testing - methods Female Hospitalization Humans Infant Intensive care Intensive Care Units Major and Brief Reports Male Nasopharynx - virology Oxygen therapy Pediatrics Ribonucleic acid RNA RNA, Viral - genetics SARS-CoV-2 - genetics SARS-CoV-2 - isolation & purification Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Viremia - epidemiology |
| title | Severe Acute Respiratory Syndrome Coronavirus 2 RNAemia and Clinical Outcomes in Children With Coronavirus Disease 2019 |
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