The ionophore thiomaltol induces rapid lysosomal accumulation of copper and apoptosis in melanoma

In this report, we investigate the toxicity of the ionophore thiomaltol (Htma) and Cu salts to melanoma. Divalent metal complexes of thiomaltol display toxicity against A375 melanoma cell culture resulting in a distinct apoptotic response at submicromolar concentrations, with toxicity of Cu(tma)2 &g...

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Veröffentlicht in:	Metallomics 2022-01, Vol.14 (1)
Hauptverfasser:	Scrivner, Ottis, Dao, Long, Newell-Rogers, M Karen, Shahandeh, Babbak, Meyskens, Frank L, Kozawa, Susan Kurumi, Liu-Smith, Feng, Plascencia-Villa, Germán, José-Yacamán, Miguel, Jia, Shang, Chang, Christopher J, Farmer, Patrick J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Copper - metabolism Copper - pharmacology Humans Ionophores - pharmacology Lysosomes - metabolism Melanoma - drug therapy Melanoma - metabolism Pyrans Thiones
Online-Zugang:	Volltext
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