A new inflammatory marker: elevated eosinophil-tolymphocyte ratio associated with presence and severity of isolated coronary artery ectasia
The pathophysiology of isolated coronary artery ectasia (CAE) involves atherosclerosis and inflammation. Eosinophils and lymphocytes have been found to play a significant role in inflammation, atherosclerosis and endothelial dysfunction. Many studies have explored the relationship between isolated C...
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| Veröffentlicht in: | Cardiovascular Journal of Africa 2020-09, Vol.31 (5), p.227-15 |
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| creator | Yilmaz, Mücahid Kayançiçek, Hidayet Korkmaz, Hasan Gözel, Nevzat Bilen, Mehmet Nail Seçen, Özlem Öner, Pinar Uku, Ökkeş Demirkiran, Suat Çekici, Yusuf Eroğlu, Orkun Ertuğrul, Kurtoğlu |
| description | The pathophysiology of isolated coronary artery ectasia (CAE) involves atherosclerosis and inflammation. Eosinophils and lymphocytes have been found to play a significant role in inflammation, atherosclerosis and endothelial dysfunction. Many studies have explored the relationship between isolated CAE and systemic inflammation. However, there are no data regarding the relationship between eosinophil-to-lymphocyte ratio (ELR) and isolated CAE. Therefore, this study analysed the relationship between ELR and isolated CAE.
All patients who underwent coronary angiography between January 2009 and June 2018 were investigated retrospectively. Of 16 240 patients, 232 patients with isolated CAE (141 males) and 247 age- and gender-matched control subjects (130 males) with normal coronary angiography (NCA) were enrolled in this study. Baseline demographic and laboratory data were obtained from the hospital database. The severity of isolated CAE was determined according to the Markis classification, vessel count and diffuseness of ectasia.
Patients with angiographic isolated CAE had significantly elevated white blood cell (WBC) and eosinophil counts and ELR values compared to patients with NCA [8.11 ± 1.75 vs 7.49 ± 1.80 × 10
cells/l,
< 0.0001; 0.22 (0.13-0.32) vs 0.19 (0.12-0.28) × 10
cells/l,
= 0.02; 0.11 (0.06-0.17) vs 0.08 (0.05-0.12),
< 0.0001. The ELR value for Markis I was significantly higher than for Markis IV (p = 0.04), and three-vessel isolated CAE was significantly higher than onevessel isolated CAE (
= 0.04). Additionally, the ELR value for diffuse ectasia (Markis class I, II and III) was significantly higher compared to focal (Markis class IV) ectasia (
= 0.02). In receiver operating characteristics (ROC) analyses, it was determined that an ELR value > 0.099, measured in isolated CAE patients at application, had a predictive specificity of 60.3% and a sensitivity of 56.5% (area under the curve: 0.604, 95% confidence interval: 0.553-0.655,
< 0.0001).
Patients with isolated CAE had higher blood eosinophil counts and ELR. Furthermore, the ELR was significantly correlated with severity of isolated CAE. These findings demonstrate that ELR may have a significant role in the aetiopathogenesis of isolated CAE. |
| doi_str_mv | 10.5830/CVJA-2019-049 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8762827</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2448636437</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2329-e5a5134af6d1eaa197b7e3b0db7a63a4b3a572b22aa8c9a5ebb5b3b3f79a713a3</originalsourceid><addsrcrecordid>eNpVkU1v1DAQhi1ERUvhyBX5yCXgjziOOSCtVoUWVeICXK2xM2ENSRxs71b5Df3TZNtSwWlGmkfvzOgh5BVnb1Ur2bvt98-bSjBuKlabJ-SMNy2rmK7V07U3RlW8NeKUPM_5J2NCtFo9I6dSMq40k2fkdkMnvKFh6gcYRygxLXSE9AvTe4oDHqBgRzHmMMV5F4aqxGEZ5130S0GaoIRIIefowx14E8qOzgkzTh4pTB3NeMAUykJjT0OOwx3mY4oTrJsgFVwL-gI5wAty0sOQ8eVDPSffPl583V5W118-XW0315UXUpgKFSgua-ibjiMAN9pplI51TkMjoXYSlBZOCIDWG1DonHLSyV4b0FyCPCcf7nPnvRux8ziVBIOdU1g_X2yEYP-fTGFnf8SDbXUjWqHXgDcPASn-3mMudgzZ4zDAhHGfrajrtpFNLY9odY_6FHNO2D-u4cweBdqjQHsUaFeBK__639se6b_G5B8-8JxB</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2448636437</pqid></control><display><type>article</type><title>A new inflammatory marker: elevated eosinophil-tolymphocyte ratio associated with presence and severity of isolated coronary artery ectasia</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Yilmaz, Mücahid ; Kayançiçek, Hidayet ; Korkmaz, Hasan ; Gözel, Nevzat ; Bilen, Mehmet Nail ; Seçen, Özlem ; Öner, Pinar ; Uku, Ökkeş ; Demirkiran, Suat ; Çekici, Yusuf ; Eroğlu, Orkun ; Ertuğrul, Kurtoğlu</creator><creatorcontrib>Yilmaz, Mücahid ; Kayançiçek, Hidayet ; Korkmaz, Hasan ; Gözel, Nevzat ; Bilen, Mehmet Nail ; Seçen, Özlem ; Öner, Pinar ; Uku, Ökkeş ; Demirkiran, Suat ; Çekici, Yusuf ; Eroğlu, Orkun ; Ertuğrul, Kurtoğlu</creatorcontrib><description>The pathophysiology of isolated coronary artery ectasia (CAE) involves atherosclerosis and inflammation. Eosinophils and lymphocytes have been found to play a significant role in inflammation, atherosclerosis and endothelial dysfunction. Many studies have explored the relationship between isolated CAE and systemic inflammation. However, there are no data regarding the relationship between eosinophil-to-lymphocyte ratio (ELR) and isolated CAE. Therefore, this study analysed the relationship between ELR and isolated CAE.
All patients who underwent coronary angiography between January 2009 and June 2018 were investigated retrospectively. Of 16 240 patients, 232 patients with isolated CAE (141 males) and 247 age- and gender-matched control subjects (130 males) with normal coronary angiography (NCA) were enrolled in this study. Baseline demographic and laboratory data were obtained from the hospital database. The severity of isolated CAE was determined according to the Markis classification, vessel count and diffuseness of ectasia.
Patients with angiographic isolated CAE had significantly elevated white blood cell (WBC) and eosinophil counts and ELR values compared to patients with NCA [8.11 ± 1.75 vs 7.49 ± 1.80 × 10
cells/l,
< 0.0001; 0.22 (0.13-0.32) vs 0.19 (0.12-0.28) × 10
cells/l,
= 0.02; 0.11 (0.06-0.17) vs 0.08 (0.05-0.12),
< 0.0001. The ELR value for Markis I was significantly higher than for Markis IV (p = 0.04), and three-vessel isolated CAE was significantly higher than onevessel isolated CAE (
= 0.04). Additionally, the ELR value for diffuse ectasia (Markis class I, II and III) was significantly higher compared to focal (Markis class IV) ectasia (
= 0.02). In receiver operating characteristics (ROC) analyses, it was determined that an ELR value > 0.099, measured in isolated CAE patients at application, had a predictive specificity of 60.3% and a sensitivity of 56.5% (area under the curve: 0.604, 95% confidence interval: 0.553-0.655,
< 0.0001).
Patients with isolated CAE had higher blood eosinophil counts and ELR. Furthermore, the ELR was significantly correlated with severity of isolated CAE. These findings demonstrate that ELR may have a significant role in the aetiopathogenesis of isolated CAE.</description><identifier>ISSN: 1995-1892</identifier><identifier>EISSN: 1680-0745</identifier><identifier>DOI: 10.5830/CVJA-2019-049</identifier><identifier>PMID: 33015703</identifier><language>eng</language><publisher>South Africa: Clinics Cardive Publishing</publisher><subject>Cardiovascular Topics ; Coronary Angiography ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - pathology ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - pathology ; Databases, Factual ; Dilatation, Pathologic ; Eosinophils ; Female ; Humans ; Lymphocyte Count ; Lymphocytes ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Severity of Illness Index</subject><ispartof>Cardiovascular Journal of Africa, 2020-09, Vol.31 (5), p.227-15</ispartof><rights>Copyright © 2020 Clinics Cardive Publishing 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2329-e5a5134af6d1eaa197b7e3b0db7a63a4b3a572b22aa8c9a5ebb5b3b3f79a713a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762827/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762827/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33015703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yilmaz, Mücahid</creatorcontrib><creatorcontrib>Kayançiçek, Hidayet</creatorcontrib><creatorcontrib>Korkmaz, Hasan</creatorcontrib><creatorcontrib>Gözel, Nevzat</creatorcontrib><creatorcontrib>Bilen, Mehmet Nail</creatorcontrib><creatorcontrib>Seçen, Özlem</creatorcontrib><creatorcontrib>Öner, Pinar</creatorcontrib><creatorcontrib>Uku, Ökkeş</creatorcontrib><creatorcontrib>Demirkiran, Suat</creatorcontrib><creatorcontrib>Çekici, Yusuf</creatorcontrib><creatorcontrib>Eroğlu, Orkun</creatorcontrib><creatorcontrib>Ertuğrul, Kurtoğlu</creatorcontrib><title>A new inflammatory marker: elevated eosinophil-tolymphocyte ratio associated with presence and severity of isolated coronary artery ectasia</title><title>Cardiovascular Journal of Africa</title><addtitle>Cardiovasc J Afr</addtitle><description>The pathophysiology of isolated coronary artery ectasia (CAE) involves atherosclerosis and inflammation. Eosinophils and lymphocytes have been found to play a significant role in inflammation, atherosclerosis and endothelial dysfunction. Many studies have explored the relationship between isolated CAE and systemic inflammation. However, there are no data regarding the relationship between eosinophil-to-lymphocyte ratio (ELR) and isolated CAE. Therefore, this study analysed the relationship between ELR and isolated CAE.
All patients who underwent coronary angiography between January 2009 and June 2018 were investigated retrospectively. Of 16 240 patients, 232 patients with isolated CAE (141 males) and 247 age- and gender-matched control subjects (130 males) with normal coronary angiography (NCA) were enrolled in this study. Baseline demographic and laboratory data were obtained from the hospital database. The severity of isolated CAE was determined according to the Markis classification, vessel count and diffuseness of ectasia.
Patients with angiographic isolated CAE had significantly elevated white blood cell (WBC) and eosinophil counts and ELR values compared to patients with NCA [8.11 ± 1.75 vs 7.49 ± 1.80 × 10
cells/l,
< 0.0001; 0.22 (0.13-0.32) vs 0.19 (0.12-0.28) × 10
cells/l,
= 0.02; 0.11 (0.06-0.17) vs 0.08 (0.05-0.12),
< 0.0001. The ELR value for Markis I was significantly higher than for Markis IV (p = 0.04), and three-vessel isolated CAE was significantly higher than onevessel isolated CAE (
= 0.04). Additionally, the ELR value for diffuse ectasia (Markis class I, II and III) was significantly higher compared to focal (Markis class IV) ectasia (
= 0.02). In receiver operating characteristics (ROC) analyses, it was determined that an ELR value > 0.099, measured in isolated CAE patients at application, had a predictive specificity of 60.3% and a sensitivity of 56.5% (area under the curve: 0.604, 95% confidence interval: 0.553-0.655,
< 0.0001).
Patients with isolated CAE had higher blood eosinophil counts and ELR. Furthermore, the ELR was significantly correlated with severity of isolated CAE. These findings demonstrate that ELR may have a significant role in the aetiopathogenesis of isolated CAE.</description><subject>Cardiovascular Topics</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - pathology</subject><subject>Databases, Factual</subject><subject>Dilatation, Pathologic</subject><subject>Eosinophils</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><issn>1995-1892</issn><issn>1680-0745</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v1DAQhi1ERUvhyBX5yCXgjziOOSCtVoUWVeICXK2xM2ENSRxs71b5Df3TZNtSwWlGmkfvzOgh5BVnb1Ur2bvt98-bSjBuKlabJ-SMNy2rmK7V07U3RlW8NeKUPM_5J2NCtFo9I6dSMq40k2fkdkMnvKFh6gcYRygxLXSE9AvTe4oDHqBgRzHmMMV5F4aqxGEZ5130S0GaoIRIIefowx14E8qOzgkzTh4pTB3NeMAUykJjT0OOwx3mY4oTrJsgFVwL-gI5wAty0sOQ8eVDPSffPl583V5W118-XW0315UXUpgKFSgua-ibjiMAN9pplI51TkMjoXYSlBZOCIDWG1DonHLSyV4b0FyCPCcf7nPnvRux8ziVBIOdU1g_X2yEYP-fTGFnf8SDbXUjWqHXgDcPASn-3mMudgzZ4zDAhHGfrajrtpFNLY9odY_6FHNO2D-u4cweBdqjQHsUaFeBK__639se6b_G5B8-8JxB</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Yilmaz, Mücahid</creator><creator>Kayançiçek, Hidayet</creator><creator>Korkmaz, Hasan</creator><creator>Gözel, Nevzat</creator><creator>Bilen, Mehmet Nail</creator><creator>Seçen, Özlem</creator><creator>Öner, Pinar</creator><creator>Uku, Ökkeş</creator><creator>Demirkiran, Suat</creator><creator>Çekici, Yusuf</creator><creator>Eroğlu, Orkun</creator><creator>Ertuğrul, Kurtoğlu</creator><general>Clinics Cardive Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202009</creationdate><title>A new inflammatory marker: elevated eosinophil-tolymphocyte ratio associated with presence and severity of isolated coronary artery ectasia</title><author>Yilmaz, Mücahid ; 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Eosinophils and lymphocytes have been found to play a significant role in inflammation, atherosclerosis and endothelial dysfunction. Many studies have explored the relationship between isolated CAE and systemic inflammation. However, there are no data regarding the relationship between eosinophil-to-lymphocyte ratio (ELR) and isolated CAE. Therefore, this study analysed the relationship between ELR and isolated CAE.
All patients who underwent coronary angiography between January 2009 and June 2018 were investigated retrospectively. Of 16 240 patients, 232 patients with isolated CAE (141 males) and 247 age- and gender-matched control subjects (130 males) with normal coronary angiography (NCA) were enrolled in this study. Baseline demographic and laboratory data were obtained from the hospital database. The severity of isolated CAE was determined according to the Markis classification, vessel count and diffuseness of ectasia.
Patients with angiographic isolated CAE had significantly elevated white blood cell (WBC) and eosinophil counts and ELR values compared to patients with NCA [8.11 ± 1.75 vs 7.49 ± 1.80 × 10
cells/l,
< 0.0001; 0.22 (0.13-0.32) vs 0.19 (0.12-0.28) × 10
cells/l,
= 0.02; 0.11 (0.06-0.17) vs 0.08 (0.05-0.12),
< 0.0001. The ELR value for Markis I was significantly higher than for Markis IV (p = 0.04), and three-vessel isolated CAE was significantly higher than onevessel isolated CAE (
= 0.04). Additionally, the ELR value for diffuse ectasia (Markis class I, II and III) was significantly higher compared to focal (Markis class IV) ectasia (
= 0.02). In receiver operating characteristics (ROC) analyses, it was determined that an ELR value > 0.099, measured in isolated CAE patients at application, had a predictive specificity of 60.3% and a sensitivity of 56.5% (area under the curve: 0.604, 95% confidence interval: 0.553-0.655,
< 0.0001).
Patients with isolated CAE had higher blood eosinophil counts and ELR. Furthermore, the ELR was significantly correlated with severity of isolated CAE. These findings demonstrate that ELR may have a significant role in the aetiopathogenesis of isolated CAE.</abstract><cop>South Africa</cop><pub>Clinics Cardive Publishing</pub><pmid>33015703</pmid><doi>10.5830/CVJA-2019-049</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1995-1892 |
| ispartof | Cardiovascular Journal of Africa, 2020-09, Vol.31 (5), p.227-15 |
| issn | 1995-1892 1680-0745 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8762827 |
| source | MEDLINE; PubMed Central; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Cardiovascular Topics Coronary Angiography Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - pathology Coronary Vessels - diagnostic imaging Coronary Vessels - pathology Databases, Factual Dilatation, Pathologic Eosinophils Female Humans Lymphocyte Count Lymphocytes Male Middle Aged Predictive Value of Tests Retrospective Studies Severity of Illness Index |
| title | A new inflammatory marker: elevated eosinophil-tolymphocyte ratio associated with presence and severity of isolated coronary artery ectasia |
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