Discovery and Optimization of 7-Alkylidenyltetrahydroindazole-Based Acylsulfonamide EP3 Antagonists

A novel series of 7-alkylidenyltetrahydroindazole-based acylsulfonamides were discovered as potent EP3 antagonists. The initial lead compound exhibited potent in vitro EP3 inhibitory activity and good selectivity against other EP receptors. In addition, compound demonstrated in vivo activity in a ra...

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Veröffentlicht in:	ACS medicinal chemistry letters 2022-01, Vol.13 (1), p.111-117
Hauptverfasser:	Zhu, Bin, Zhang, Xuqing, Guo, Lili, Rankin, Matthew, Bakaj, Ivona, Ho, George, Lee, Seunghun P, Norquay, Lisa, Macielag, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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