Association between serum inflammatory parameters and the disease severity in COVID‐19 patients
Objective Most patients infected with the novel coronavirus (SARS‐CoV‐2), as the causative agent of COVID‐19 disease, show mild symptoms, but some of them develop severe illness. The purpose of this study was to analyze the blood markers of COVID‐19 patients and to investigate the correlation betwee...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 2022-01, Vol.36 (1), p.e24162-n/a |
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| creator | Mardani, Rajab namavar, Mehrnoush ghorbi, Elham Shoja, Zabihollah Zali, Fatemeh Kaghazian, Hooman Aghasadeghi, Mohammad Reza Sadeghi, Seyed Amir Sabeti, Shahram Darazam, Ilad Alavi Ahmadi, Nayebali Mousavi‐Nasab, Seyed Dawood |
| description | Objective
Most patients infected with the novel coronavirus (SARS‐CoV‐2), as the causative agent of COVID‐19 disease, show mild symptoms, but some of them develop severe illness. The purpose of this study was to analyze the blood markers of COVID‐19 patients and to investigate the correlation between serum inflammatory cytokines and the disease severity.
Methods
In this prospective cross‐sectional study, 50 patients with COVID‐19 and 20 patients without COVID‐19 were enrolled. According to ICU admission criteria, patients were divided into two groups of non‐severe and severe. Differences in the serum levels of C‐reactive protein (CRP), IL‐6, and TNF‐α, as well as erythrocyte sedimentation rate (ESR), lymphocytes (LYM) count, and neutrophils (NEU) count between the two groups were determined and analyzed.
Results
Out of the 50 patients with COVID‐19, 14 were diagnosed as severe cases. There was no significant difference between the two groups of COVID‐19 patients in terms of gender and age. Blood tests of COVID‐19 patients showed a significant decrease and increase in NEU and LYM counts, respectively. There were significant differences in the serum levels of IL‐6, TNF‐α, and CRP between the severe and non‐severe groups, which were higher in the severe group.
Also, there was a significant correlation between the disease severity and CRP with ESR (r = 0.79), CRP with IL‐6 (r = 0.74), LYM with NEU (r = −0.97), and ESR with TNF‐α (r = 0.7).
Conclusion
The findings of this study, as the first study in Iran, suggest that the levels of IL‐6, TNF‐α, ESR, and CRP could be used to predict the severity of COVID‐19 disease.
Serum inflammatory parameters were analyzed in patients with severe and non‐severe COVID‐19. The serum levels of LYM, CRP, IL‐6, TNF‐α and ESR in severe patients were significantly higher than in non‐severe patients. Measurement of inflammatory markers might help clinicians monitor and evaluate the severity and prognosis of COVID‐19. |
| doi_str_mv | 10.1002/jcla.24162 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8761446</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2619993825</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4762-6e83d0356d9049783a91eb2b48e265773e1e3aebbbd46f81f1566bc4725e0b933</originalsourceid><addsrcrecordid>eNp9kctu1DAUhi1ERaeFDQ-AIrGpKqX4Fl82SKPh0qKRugG2lp2cUI-SeLCdVrPjEXhGngS301bAgtVZ-Pu_c6wfoZcEnxGM6ZtNO9gzyomgT9CCYK1qqmjzFC2wUrJWmLBDdJTSBmOsNBHP0CHjSnIs9QLZZUqh9Tb7MFUO8g3AVCWI81j5qR_sONoc4q7a2mhHyBBTZaeuyldQdT6BTVDoa4g-70qgWl1-vXj368dPoksie5hyeo4OejskeHE_j9GXD-8_r87r9eXHi9VyXbdcCloLUKzDrBGdxlxLxawm4KjjCqhopGRAgFlwznVc9Ir0pBHClSxtADvN2DF6u_duZzdC15bd0Q5mG_1o484E683fL5O_Mt_CtVFSEM5FEZzcC2L4PkPKZvSphWGwE4Q5GSqwbLTCXBX09T_oJsxxKt8rFNFas1JAoU73VBtDShH6x2MINrfNmdvmzF1zBX715_mP6ENVBSB74MYPsPuPynxarZd76W-CJqUu</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2619993825</pqid></control><display><type>article</type><title>Association between serum inflammatory parameters and the disease severity in COVID‐19 patients</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Mardani, Rajab ; namavar, Mehrnoush ; ghorbi, Elham ; Shoja, Zabihollah ; Zali, Fatemeh ; Kaghazian, Hooman ; Aghasadeghi, Mohammad Reza ; Sadeghi, Seyed Amir ; Sabeti, Shahram ; Darazam, Ilad Alavi ; Ahmadi, Nayebali ; Mousavi‐Nasab, Seyed Dawood</creator><creatorcontrib>Mardani, Rajab ; namavar, Mehrnoush ; ghorbi, Elham ; Shoja, Zabihollah ; Zali, Fatemeh ; Kaghazian, Hooman ; Aghasadeghi, Mohammad Reza ; Sadeghi, Seyed Amir ; Sabeti, Shahram ; Darazam, Ilad Alavi ; Ahmadi, Nayebali ; Mousavi‐Nasab, Seyed Dawood</creatorcontrib><description>Objective
Most patients infected with the novel coronavirus (SARS‐CoV‐2), as the causative agent of COVID‐19 disease, show mild symptoms, but some of them develop severe illness. The purpose of this study was to analyze the blood markers of COVID‐19 patients and to investigate the correlation between serum inflammatory cytokines and the disease severity.
Methods
In this prospective cross‐sectional study, 50 patients with COVID‐19 and 20 patients without COVID‐19 were enrolled. According to ICU admission criteria, patients were divided into two groups of non‐severe and severe. Differences in the serum levels of C‐reactive protein (CRP), IL‐6, and TNF‐α, as well as erythrocyte sedimentation rate (ESR), lymphocytes (LYM) count, and neutrophils (NEU) count between the two groups were determined and analyzed.
Results
Out of the 50 patients with COVID‐19, 14 were diagnosed as severe cases. There was no significant difference between the two groups of COVID‐19 patients in terms of gender and age. Blood tests of COVID‐19 patients showed a significant decrease and increase in NEU and LYM counts, respectively. There were significant differences in the serum levels of IL‐6, TNF‐α, and CRP between the severe and non‐severe groups, which were higher in the severe group.
Also, there was a significant correlation between the disease severity and CRP with ESR (r = 0.79), CRP with IL‐6 (r = 0.74), LYM with NEU (r = −0.97), and ESR with TNF‐α (r = 0.7).
Conclusion
The findings of this study, as the first study in Iran, suggest that the levels of IL‐6, TNF‐α, ESR, and CRP could be used to predict the severity of COVID‐19 disease.
Serum inflammatory parameters were analyzed in patients with severe and non‐severe COVID‐19. The serum levels of LYM, CRP, IL‐6, TNF‐α and ESR in severe patients were significantly higher than in non‐severe patients. Measurement of inflammatory markers might help clinicians monitor and evaluate the severity and prognosis of COVID‐19.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.24162</identifier><identifier>PMID: 34874079</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adult ; Age ; Aged ; Biomarkers ; Biomarkers - blood ; Blood Sedimentation ; C-Reactive Protein - analysis ; Case-Control Studies ; Coronaviruses ; Correlation analysis ; COVID-19 ; COVID-19 - blood ; COVID-19 - etiology ; Cross-Sectional Studies ; CRP ; Cytokines ; Disease ; ErbB-2 protein ; Erythrocyte sedimentation rate ; Female ; Gender ; Humans ; IL‐6 ; Immune system ; Inflammation - blood ; Inflammation - virology ; Intensive care ; Interleukin-6 - blood ; Laboratories ; Leukocytes (neutrophilic) ; Lymphocyte Count ; Lymphocytes ; Male ; Middle Aged ; Pneumonia ; Prospective Studies ; Proteins ; SARS‐CoV‐2 ; Serum levels ; Severe acute respiratory syndrome coronavirus 2 ; Severity of Illness Index ; Statistical analysis ; TNF‐α ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - blood ; Tumor necrosis factor-TNF ; Young Adult</subject><ispartof>Journal of clinical laboratory analysis, 2022-01, Vol.36 (1), p.e24162-n/a</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC.</rights><rights>2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.</rights><rights>2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4762-6e83d0356d9049783a91eb2b48e265773e1e3aebbbd46f81f1566bc4725e0b933</citedby><cites>FETCH-LOGICAL-c4762-6e83d0356d9049783a91eb2b48e265773e1e3aebbbd46f81f1566bc4725e0b933</cites><orcidid>0000-0002-4440-335X ; 0000-0001-8506-1942</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761446/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8761446/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34874079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mardani, Rajab</creatorcontrib><creatorcontrib>namavar, Mehrnoush</creatorcontrib><creatorcontrib>ghorbi, Elham</creatorcontrib><creatorcontrib>Shoja, Zabihollah</creatorcontrib><creatorcontrib>Zali, Fatemeh</creatorcontrib><creatorcontrib>Kaghazian, Hooman</creatorcontrib><creatorcontrib>Aghasadeghi, Mohammad Reza</creatorcontrib><creatorcontrib>Sadeghi, Seyed Amir</creatorcontrib><creatorcontrib>Sabeti, Shahram</creatorcontrib><creatorcontrib>Darazam, Ilad Alavi</creatorcontrib><creatorcontrib>Ahmadi, Nayebali</creatorcontrib><creatorcontrib>Mousavi‐Nasab, Seyed Dawood</creatorcontrib><title>Association between serum inflammatory parameters and the disease severity in COVID‐19 patients</title><title>Journal of clinical laboratory analysis</title><addtitle>J Clin Lab Anal</addtitle><description>Objective
Most patients infected with the novel coronavirus (SARS‐CoV‐2), as the causative agent of COVID‐19 disease, show mild symptoms, but some of them develop severe illness. The purpose of this study was to analyze the blood markers of COVID‐19 patients and to investigate the correlation between serum inflammatory cytokines and the disease severity.
Methods
In this prospective cross‐sectional study, 50 patients with COVID‐19 and 20 patients without COVID‐19 were enrolled. According to ICU admission criteria, patients were divided into two groups of non‐severe and severe. Differences in the serum levels of C‐reactive protein (CRP), IL‐6, and TNF‐α, as well as erythrocyte sedimentation rate (ESR), lymphocytes (LYM) count, and neutrophils (NEU) count between the two groups were determined and analyzed.
Results
Out of the 50 patients with COVID‐19, 14 were diagnosed as severe cases. There was no significant difference between the two groups of COVID‐19 patients in terms of gender and age. Blood tests of COVID‐19 patients showed a significant decrease and increase in NEU and LYM counts, respectively. There were significant differences in the serum levels of IL‐6, TNF‐α, and CRP between the severe and non‐severe groups, which were higher in the severe group.
Also, there was a significant correlation between the disease severity and CRP with ESR (r = 0.79), CRP with IL‐6 (r = 0.74), LYM with NEU (r = −0.97), and ESR with TNF‐α (r = 0.7).
Conclusion
The findings of this study, as the first study in Iran, suggest that the levels of IL‐6, TNF‐α, ESR, and CRP could be used to predict the severity of COVID‐19 disease.
Serum inflammatory parameters were analyzed in patients with severe and non‐severe COVID‐19. The serum levels of LYM, CRP, IL‐6, TNF‐α and ESR in severe patients were significantly higher than in non‐severe patients. Measurement of inflammatory markers might help clinicians monitor and evaluate the severity and prognosis of COVID‐19.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood Sedimentation</subject><subject>C-Reactive Protein - analysis</subject><subject>Case-Control Studies</subject><subject>Coronaviruses</subject><subject>Correlation analysis</subject><subject>COVID-19</subject><subject>COVID-19 - blood</subject><subject>COVID-19 - etiology</subject><subject>Cross-Sectional Studies</subject><subject>CRP</subject><subject>Cytokines</subject><subject>Disease</subject><subject>ErbB-2 protein</subject><subject>Erythrocyte sedimentation rate</subject><subject>Female</subject><subject>Gender</subject><subject>Humans</subject><subject>IL‐6</subject><subject>Immune system</subject><subject>Inflammation - blood</subject><subject>Inflammation - virology</subject><subject>Intensive care</subject><subject>Interleukin-6 - blood</subject><subject>Laboratories</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pneumonia</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>SARS‐CoV‐2</subject><subject>Serum levels</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Severity of Illness Index</subject><subject>Statistical analysis</subject><subject>TNF‐α</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor necrosis factor-TNF</subject><subject>Young Adult</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kctu1DAUhi1ERaeFDQ-AIrGpKqX4Fl82SKPh0qKRugG2lp2cUI-SeLCdVrPjEXhGngS301bAgtVZ-Pu_c6wfoZcEnxGM6ZtNO9gzyomgT9CCYK1qqmjzFC2wUrJWmLBDdJTSBmOsNBHP0CHjSnIs9QLZZUqh9Tb7MFUO8g3AVCWI81j5qR_sONoc4q7a2mhHyBBTZaeuyldQdT6BTVDoa4g-70qgWl1-vXj368dPoksie5hyeo4OejskeHE_j9GXD-8_r87r9eXHi9VyXbdcCloLUKzDrBGdxlxLxawm4KjjCqhopGRAgFlwznVc9Ir0pBHClSxtADvN2DF6u_duZzdC15bd0Q5mG_1o484E683fL5O_Mt_CtVFSEM5FEZzcC2L4PkPKZvSphWGwE4Q5GSqwbLTCXBX09T_oJsxxKt8rFNFas1JAoU73VBtDShH6x2MINrfNmdvmzF1zBX715_mP6ENVBSB74MYPsPuPynxarZd76W-CJqUu</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Mardani, Rajab</creator><creator>namavar, Mehrnoush</creator><creator>ghorbi, Elham</creator><creator>Shoja, Zabihollah</creator><creator>Zali, Fatemeh</creator><creator>Kaghazian, Hooman</creator><creator>Aghasadeghi, Mohammad Reza</creator><creator>Sadeghi, Seyed Amir</creator><creator>Sabeti, Shahram</creator><creator>Darazam, Ilad Alavi</creator><creator>Ahmadi, Nayebali</creator><creator>Mousavi‐Nasab, Seyed Dawood</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4440-335X</orcidid><orcidid>https://orcid.org/0000-0001-8506-1942</orcidid></search><sort><creationdate>202201</creationdate><title>Association between serum inflammatory parameters and the disease severity in COVID‐19 patients</title><author>Mardani, Rajab ; namavar, Mehrnoush ; ghorbi, Elham ; Shoja, Zabihollah ; Zali, Fatemeh ; Kaghazian, Hooman ; Aghasadeghi, Mohammad Reza ; Sadeghi, Seyed Amir ; Sabeti, Shahram ; Darazam, Ilad Alavi ; Ahmadi, Nayebali ; Mousavi‐Nasab, Seyed Dawood</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4762-6e83d0356d9049783a91eb2b48e265773e1e3aebbbd46f81f1566bc4725e0b933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood Sedimentation</topic><topic>C-Reactive Protein - analysis</topic><topic>Case-Control Studies</topic><topic>Coronaviruses</topic><topic>Correlation analysis</topic><topic>COVID-19</topic><topic>COVID-19 - blood</topic><topic>COVID-19 - etiology</topic><topic>Cross-Sectional Studies</topic><topic>CRP</topic><topic>Cytokines</topic><topic>Disease</topic><topic>ErbB-2 protein</topic><topic>Erythrocyte sedimentation rate</topic><topic>Female</topic><topic>Gender</topic><topic>Humans</topic><topic>IL‐6</topic><topic>Immune system</topic><topic>Inflammation - blood</topic><topic>Inflammation - virology</topic><topic>Intensive care</topic><topic>Interleukin-6 - blood</topic><topic>Laboratories</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pneumonia</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>SARS‐CoV‐2</topic><topic>Serum levels</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Severity of Illness Index</topic><topic>Statistical analysis</topic><topic>TNF‐α</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor necrosis factor-TNF</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mardani, Rajab</creatorcontrib><creatorcontrib>namavar, Mehrnoush</creatorcontrib><creatorcontrib>ghorbi, Elham</creatorcontrib><creatorcontrib>Shoja, Zabihollah</creatorcontrib><creatorcontrib>Zali, Fatemeh</creatorcontrib><creatorcontrib>Kaghazian, Hooman</creatorcontrib><creatorcontrib>Aghasadeghi, Mohammad Reza</creatorcontrib><creatorcontrib>Sadeghi, Seyed Amir</creatorcontrib><creatorcontrib>Sabeti, Shahram</creatorcontrib><creatorcontrib>Darazam, Ilad Alavi</creatorcontrib><creatorcontrib>Ahmadi, Nayebali</creatorcontrib><creatorcontrib>Mousavi‐Nasab, Seyed Dawood</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mardani, Rajab</au><au>namavar, Mehrnoush</au><au>ghorbi, Elham</au><au>Shoja, Zabihollah</au><au>Zali, Fatemeh</au><au>Kaghazian, Hooman</au><au>Aghasadeghi, Mohammad Reza</au><au>Sadeghi, Seyed Amir</au><au>Sabeti, Shahram</au><au>Darazam, Ilad Alavi</au><au>Ahmadi, Nayebali</au><au>Mousavi‐Nasab, Seyed Dawood</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between serum inflammatory parameters and the disease severity in COVID‐19 patients</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J Clin Lab Anal</addtitle><date>2022-01</date><risdate>2022</risdate><volume>36</volume><issue>1</issue><spage>e24162</spage><epage>n/a</epage><pages>e24162-n/a</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>Objective
Most patients infected with the novel coronavirus (SARS‐CoV‐2), as the causative agent of COVID‐19 disease, show mild symptoms, but some of them develop severe illness. The purpose of this study was to analyze the blood markers of COVID‐19 patients and to investigate the correlation between serum inflammatory cytokines and the disease severity.
Methods
In this prospective cross‐sectional study, 50 patients with COVID‐19 and 20 patients without COVID‐19 were enrolled. According to ICU admission criteria, patients were divided into two groups of non‐severe and severe. Differences in the serum levels of C‐reactive protein (CRP), IL‐6, and TNF‐α, as well as erythrocyte sedimentation rate (ESR), lymphocytes (LYM) count, and neutrophils (NEU) count between the two groups were determined and analyzed.
Results
Out of the 50 patients with COVID‐19, 14 were diagnosed as severe cases. There was no significant difference between the two groups of COVID‐19 patients in terms of gender and age. Blood tests of COVID‐19 patients showed a significant decrease and increase in NEU and LYM counts, respectively. There were significant differences in the serum levels of IL‐6, TNF‐α, and CRP between the severe and non‐severe groups, which were higher in the severe group.
Also, there was a significant correlation between the disease severity and CRP with ESR (r = 0.79), CRP with IL‐6 (r = 0.74), LYM with NEU (r = −0.97), and ESR with TNF‐α (r = 0.7).
Conclusion
The findings of this study, as the first study in Iran, suggest that the levels of IL‐6, TNF‐α, ESR, and CRP could be used to predict the severity of COVID‐19 disease.
Serum inflammatory parameters were analyzed in patients with severe and non‐severe COVID‐19. The serum levels of LYM, CRP, IL‐6, TNF‐α and ESR in severe patients were significantly higher than in non‐severe patients. Measurement of inflammatory markers might help clinicians monitor and evaluate the severity and prognosis of COVID‐19.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>34874079</pmid><doi>10.1002/jcla.24162</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-4440-335X</orcidid><orcidid>https://orcid.org/0000-0001-8506-1942</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-8013 |
| ispartof | Journal of clinical laboratory analysis, 2022-01, Vol.36 (1), p.e24162-n/a |
| issn | 0887-8013 1098-2825 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8761446 |
| source | MEDLINE; Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Age Aged Biomarkers Biomarkers - blood Blood Sedimentation C-Reactive Protein - analysis Case-Control Studies Coronaviruses Correlation analysis COVID-19 COVID-19 - blood COVID-19 - etiology Cross-Sectional Studies CRP Cytokines Disease ErbB-2 protein Erythrocyte sedimentation rate Female Gender Humans IL‐6 Immune system Inflammation - blood Inflammation - virology Intensive care Interleukin-6 - blood Laboratories Leukocytes (neutrophilic) Lymphocyte Count Lymphocytes Male Middle Aged Pneumonia Prospective Studies Proteins SARS‐CoV‐2 Serum levels Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Statistical analysis TNF‐α Tumor necrosis factor Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-TNF Young Adult |
| title | Association between serum inflammatory parameters and the disease severity in COVID‐19 patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T05%3A21%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20serum%20inflammatory%20parameters%20and%20the%20disease%20severity%20in%20COVID%E2%80%9019%20patients&rft.jtitle=Journal%20of%20clinical%20laboratory%20analysis&rft.au=Mardani,%20Rajab&rft.date=2022-01&rft.volume=36&rft.issue=1&rft.spage=e24162&rft.epage=n/a&rft.pages=e24162-n/a&rft.issn=0887-8013&rft.eissn=1098-2825&rft_id=info:doi/10.1002/jcla.24162&rft_dat=%3Cproquest_pubme%3E2619993825%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2619993825&rft_id=info:pmid/34874079&rfr_iscdi=true |