Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity

While the pathophysiology of schizophrenia has been extensively investigated using homogenized postmortem brain samples, few studies have examined changes in brain samples with techniques that may attribute perturbations to specific cell types. To fill this gap, we performed microarray assays on mRN...

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Veröffentlicht in:	Molecular psychiatry 2021-12, Vol.26 (12), p.7699-7708
Hauptverfasser:	Wu, Xiaojun, Shukla, Rammohan, Alganem, Khaled, Zhang, Xiaolu, Eby, Hunter M., Devine, Emily A., Depasquale, Erica, Reigle, James, Simmons, Micah, Hahn, Margaret K., Au-Yeung, Christy, Asgariroozbehani, Roshanak, Hahn, Chang-Gyu, Haroutunian, Vahram, Meller, Jarek, Meador-Woodruff, James, McCullumsmith, Robert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 38/90 45/61 631/337 692/699/476/1799 Antipsychotic Agents - metabolism Antipsychotics Behavioral Sciences Bioinformatics Biological Psychology Chemotaxis Complications and side effects Cortex (cingulate) Cytokines DNA microarrays Gene expression Gene set enrichment analysis Genetic aspects Glutamatergic transmission Health aspects Humans Immunity (Disease) Lasers Medicine Medicine & Public Health Mental disorders Natural immunity Neurons Neurons - metabolism Neurosciences Olfaction Pathophysiology Pharmacotherapy Physiological aspects Psychiatry Psychotropic drugs Pyramidal cells Pyramidal Cells - metabolism RNA, Messenger - metabolism Schizophrenia Schizophrenia - genetics Schizophrenia - metabolism Synapses Transcription Ubiquitin
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