Persistently elevated complement alternative pathway biomarkers in COVID-19 correlate with hypoxemia and predict in-hospital mortality

Mechanisms underlying the SARS-CoV-2-triggered hyperacute thrombo-inflammatory response that causes multi-organ damage in coronavirus disease 2019 (COVID-19) are poorly understood. Several lines of evidence implicate overactivation of complement. To delineate the involvement of complement in COVID-1...

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Veröffentlicht in:	Medical microbiology and immunology 2022-02, Vol.211 (1), p.37-48
Hauptverfasser:	Leatherdale, Alexander, Stukas, Sophie, Lei, Victor, West, Henry E., Campbell, Christopher J., Hoiland, Ryan L., Cooper, Jennifer, Wellington, Cheryl L., Sekhon, Mypinder S., Pryzdial, Edward L. G., Conway, Edward M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative pathway Biomarkers Biomedical and Life Sciences Biomedicine C-reactive protein Complement Activation Complement component C5a Coronaviruses COVID-19 Ferritin Hospital Mortality Humans Hypoxemia Hypoxia Immunology Inflammation Interleukin 6 Lung diseases Medical Microbiology Mortality Original Investigation Patients Respiratory function SARS-CoV-2 Serum levels Severe acute respiratory syndrome coronavirus 2 Virology
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