Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain
Metabolic syndromes, including obesity, cause neuropathophysiological changes in the brain, resulting in cognitive deficits. Only a few studies explored the contribution of non-coding genes in these pathophysiologies. Recently, we identified obesity-linked circular RNAs (circRNA) by analyzing the br...
Gespeichert in:
| Veröffentlicht in: | Molecular psychiatry 2021-11, Vol.26 (11), p.6350-6364 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 6364 |
|---|---|
| container_issue | 11 |
| container_start_page | 6350 |
| container_title | Molecular psychiatry |
| container_volume | 26 |
| creator | Yoon, Gwangho Lim, Yeong-Hwan Jo, Danbi Ryu, Juhee Song, Juhyun Kim, Young-Kook |
| description | Metabolic syndromes, including obesity, cause neuropathophysiological changes in the brain, resulting in cognitive deficits. Only a few studies explored the contribution of non-coding genes in these pathophysiologies. Recently, we identified obesity-linked circular RNAs (circRNA) by analyzing the brain cortices of high-fat-fed obese mice. In this study, we scrutinized a conserved and neuron-specific circRNA, circTshz2-2, which affects neuronal cell cycle and spatial memory in the brain. Transcriptomic and cellular analysis indicated that circTshz2-2 dysregulation altered the expression of cell division-related genes and induced cell cycle arrest at the G2/M phase of the neuron. We found that circTshz2-2 bound to the YY1 transcriptional complex and suppressed
Bdnf
transcription. Suppression of circTshz2-2 increased BDNF expression and reduced G2/M checkpoint proteins such as Cyclin B2 and CDK1 through BDNF/TrkB signaling pathway, resulting in cell cycle arrest and neurite elongation. Inversely, overexpression of circTshz2-2 decreased BDNF expression, induced cell cycle proteins, and shortened the neurite length, indicating that circTshz2-2 regulates neuronal cell cycle and structure. Finally, we showed that circTshz2-2 affects spatial memory in wild-type and obese mice. Our data have revealed potential regulatory roles of obesity-related circTshz2-2 on the neuronal cell cycle and memory function providing a novel link between metabolic syndromes and cognitive deficits. |
| doi_str_mv | 10.1038/s41380-021-01303-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8760052</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A691095297</galeid><sourcerecordid>A691095297</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-5431c02f79a06f5e60f406f3a3c29ee435db0eb8ca5109d3ec31e6dda3d016973</originalsourceid><addsrcrecordid>eNp9Ul1rFDEUHcRia_UP-CABX3xJm--ZeRGW4hcUC1KfQya5s5s6k6zJTOn6683u1tYWaQLJzb3nnuSEU1VvKDmhhDenWVDeEEwYxYRywvHNs-qIilphKevmeYm5bLGgjTisXuZ8Rci2KF9Uh1xIRRVlR5W_6CD7aYMHH36CQ9YnOw8moe_fFrvDZV79ZpihBMuSnyCjaQUowJxiMAOyMJRlYwdAJjiU12byJT3CGNMG-bBDd8n48Ko66M2Q4fXtflz9-PTx8uwLPr_4_PVscY6tFHTCUnBqCevr1hDVS1CkFyXghlvWAgguXUega6yRlLSOg-UUlHOGO0JVW_Pj6sOedz13IzgLYUpm0OvkR5M2OhqvH1aCX-llvNZNrQiRrBC8vyVI8dcMedKjz1udJkCcs2ayVkqKuiEF-u4R9CrOqfxLQSnaKloGu0ctzQDahz6We-2WVC9UW1RItnv3yX9QZToYvY0Bel_yDxrYvsGmmHOC_k4jJXprEL03iC4G0TuD6JvS9Pbf37lr-euIAuB7QC6lsIR0L-kJ2j_xQ8X-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2619611112</pqid></control><display><type>article</type><title>Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Yoon, Gwangho ; Lim, Yeong-Hwan ; Jo, Danbi ; Ryu, Juhee ; Song, Juhyun ; Kim, Young-Kook</creator><creatorcontrib>Yoon, Gwangho ; Lim, Yeong-Hwan ; Jo, Danbi ; Ryu, Juhee ; Song, Juhyun ; Kim, Young-Kook</creatorcontrib><description>Metabolic syndromes, including obesity, cause neuropathophysiological changes in the brain, resulting in cognitive deficits. Only a few studies explored the contribution of non-coding genes in these pathophysiologies. Recently, we identified obesity-linked circular RNAs (circRNA) by analyzing the brain cortices of high-fat-fed obese mice. In this study, we scrutinized a conserved and neuron-specific circRNA, circTshz2-2, which affects neuronal cell cycle and spatial memory in the brain. Transcriptomic and cellular analysis indicated that circTshz2-2 dysregulation altered the expression of cell division-related genes and induced cell cycle arrest at the G2/M phase of the neuron. We found that circTshz2-2 bound to the YY1 transcriptional complex and suppressed
Bdnf
transcription. Suppression of circTshz2-2 increased BDNF expression and reduced G2/M checkpoint proteins such as Cyclin B2 and CDK1 through BDNF/TrkB signaling pathway, resulting in cell cycle arrest and neurite elongation. Inversely, overexpression of circTshz2-2 decreased BDNF expression, induced cell cycle proteins, and shortened the neurite length, indicating that circTshz2-2 regulates neuronal cell cycle and structure. Finally, we showed that circTshz2-2 affects spatial memory in wild-type and obese mice. Our data have revealed potential regulatory roles of obesity-related circTshz2-2 on the neuronal cell cycle and memory function providing a novel link between metabolic syndromes and cognitive deficits.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/s41380-021-01303-x</identifier><identifier>PMID: 34561612</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/39 ; 38/89 ; 38/90 ; 38/91 ; 631/337 ; 631/378 ; 631/80 ; Animals ; Behavioral Sciences ; Biological Psychology ; Brain - metabolism ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - metabolism ; Cell cycle ; Cell Cycle Proteins - metabolism ; Cell Division ; Circular RNA ; Cognitive ability ; Genetic aspects ; Growth ; Health aspects ; Medicine ; Medicine & Public Health ; Memory ; Metabolic syndrome ; Mice ; Neurons ; Neurons - metabolism ; Neurosciences ; Non-coding RNA ; Obesity ; Obesity - genetics ; Pharmacotherapy ; Psychiatry ; RNA ; RNA, Circular - genetics ; Signal transduction ; Spatial Memory ; Transcription ; Transcriptomics ; TrkB receptors ; YY1 protein</subject><ispartof>Molecular psychiatry, 2021-11, Vol.26 (11), p.6350-6364</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-5431c02f79a06f5e60f406f3a3c29ee435db0eb8ca5109d3ec31e6dda3d016973</citedby><cites>FETCH-LOGICAL-c541t-5431c02f79a06f5e60f406f3a3c29ee435db0eb8ca5109d3ec31e6dda3d016973</cites><orcidid>0000-0002-9165-8507 ; 0000-0001-6434-2235 ; 0000-0001-8132-4389</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41380-021-01303-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41380-021-01303-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,778,782,883,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34561612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoon, Gwangho</creatorcontrib><creatorcontrib>Lim, Yeong-Hwan</creatorcontrib><creatorcontrib>Jo, Danbi</creatorcontrib><creatorcontrib>Ryu, Juhee</creatorcontrib><creatorcontrib>Song, Juhyun</creatorcontrib><creatorcontrib>Kim, Young-Kook</creatorcontrib><title>Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Metabolic syndromes, including obesity, cause neuropathophysiological changes in the brain, resulting in cognitive deficits. Only a few studies explored the contribution of non-coding genes in these pathophysiologies. Recently, we identified obesity-linked circular RNAs (circRNA) by analyzing the brain cortices of high-fat-fed obese mice. In this study, we scrutinized a conserved and neuron-specific circRNA, circTshz2-2, which affects neuronal cell cycle and spatial memory in the brain. Transcriptomic and cellular analysis indicated that circTshz2-2 dysregulation altered the expression of cell division-related genes and induced cell cycle arrest at the G2/M phase of the neuron. We found that circTshz2-2 bound to the YY1 transcriptional complex and suppressed
Bdnf
transcription. Suppression of circTshz2-2 increased BDNF expression and reduced G2/M checkpoint proteins such as Cyclin B2 and CDK1 through BDNF/TrkB signaling pathway, resulting in cell cycle arrest and neurite elongation. Inversely, overexpression of circTshz2-2 decreased BDNF expression, induced cell cycle proteins, and shortened the neurite length, indicating that circTshz2-2 regulates neuronal cell cycle and structure. Finally, we showed that circTshz2-2 affects spatial memory in wild-type and obese mice. Our data have revealed potential regulatory roles of obesity-related circTshz2-2 on the neuronal cell cycle and memory function providing a novel link between metabolic syndromes and cognitive deficits.</description><subject>38/39</subject><subject>38/89</subject><subject>38/90</subject><subject>38/91</subject><subject>631/337</subject><subject>631/378</subject><subject>631/80</subject><subject>Animals</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Brain - metabolism</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Cell cycle</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Division</subject><subject>Circular RNA</subject><subject>Cognitive ability</subject><subject>Genetic aspects</subject><subject>Growth</subject><subject>Health aspects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Memory</subject><subject>Metabolic syndrome</subject><subject>Mice</subject><subject>Neurons</subject><subject>Neurons - metabolism</subject><subject>Neurosciences</subject><subject>Non-coding RNA</subject><subject>Obesity</subject><subject>Obesity - genetics</subject><subject>Pharmacotherapy</subject><subject>Psychiatry</subject><subject>RNA</subject><subject>RNA, Circular - genetics</subject><subject>Signal transduction</subject><subject>Spatial Memory</subject><subject>Transcription</subject><subject>Transcriptomics</subject><subject>TrkB receptors</subject><subject>YY1 protein</subject><issn>1359-4184</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9Ul1rFDEUHcRia_UP-CABX3xJm--ZeRGW4hcUC1KfQya5s5s6k6zJTOn6683u1tYWaQLJzb3nnuSEU1VvKDmhhDenWVDeEEwYxYRywvHNs-qIilphKevmeYm5bLGgjTisXuZ8Rci2KF9Uh1xIRRVlR5W_6CD7aYMHH36CQ9YnOw8moe_fFrvDZV79ZpihBMuSnyCjaQUowJxiMAOyMJRlYwdAJjiU12byJT3CGNMG-bBDd8n48Ko66M2Q4fXtflz9-PTx8uwLPr_4_PVscY6tFHTCUnBqCevr1hDVS1CkFyXghlvWAgguXUega6yRlLSOg-UUlHOGO0JVW_Pj6sOedz13IzgLYUpm0OvkR5M2OhqvH1aCX-llvNZNrQiRrBC8vyVI8dcMedKjz1udJkCcs2ayVkqKuiEF-u4R9CrOqfxLQSnaKloGu0ctzQDahz6We-2WVC9UW1RItnv3yX9QZToYvY0Bel_yDxrYvsGmmHOC_k4jJXprEL03iC4G0TuD6JvS9Pbf37lr-euIAuB7QC6lsIR0L-kJ2j_xQ8X-</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Yoon, Gwangho</creator><creator>Lim, Yeong-Hwan</creator><creator>Jo, Danbi</creator><creator>Ryu, Juhee</creator><creator>Song, Juhyun</creator><creator>Kim, Young-Kook</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9165-8507</orcidid><orcidid>https://orcid.org/0000-0001-6434-2235</orcidid><orcidid>https://orcid.org/0000-0001-8132-4389</orcidid></search><sort><creationdate>20211101</creationdate><title>Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain</title><author>Yoon, Gwangho ; Lim, Yeong-Hwan ; Jo, Danbi ; Ryu, Juhee ; Song, Juhyun ; Kim, Young-Kook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-5431c02f79a06f5e60f406f3a3c29ee435db0eb8ca5109d3ec31e6dda3d016973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>38/39</topic><topic>38/89</topic><topic>38/90</topic><topic>38/91</topic><topic>631/337</topic><topic>631/378</topic><topic>631/80</topic><topic>Animals</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Brain - metabolism</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Cell cycle</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell Division</topic><topic>Circular RNA</topic><topic>Cognitive ability</topic><topic>Genetic aspects</topic><topic>Growth</topic><topic>Health aspects</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Memory</topic><topic>Metabolic syndrome</topic><topic>Mice</topic><topic>Neurons</topic><topic>Neurons - metabolism</topic><topic>Neurosciences</topic><topic>Non-coding RNA</topic><topic>Obesity</topic><topic>Obesity - genetics</topic><topic>Pharmacotherapy</topic><topic>Psychiatry</topic><topic>RNA</topic><topic>RNA, Circular - genetics</topic><topic>Signal transduction</topic><topic>Spatial Memory</topic><topic>Transcription</topic><topic>Transcriptomics</topic><topic>TrkB receptors</topic><topic>YY1 protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoon, Gwangho</creatorcontrib><creatorcontrib>Lim, Yeong-Hwan</creatorcontrib><creatorcontrib>Jo, Danbi</creatorcontrib><creatorcontrib>Ryu, Juhee</creatorcontrib><creatorcontrib>Song, Juhyun</creatorcontrib><creatorcontrib>Kim, Young-Kook</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoon, Gwangho</au><au>Lim, Yeong-Hwan</au><au>Jo, Danbi</au><au>Ryu, Juhee</au><au>Song, Juhyun</au><au>Kim, Young-Kook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>26</volume><issue>11</issue><spage>6350</spage><epage>6364</epage><pages>6350-6364</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Metabolic syndromes, including obesity, cause neuropathophysiological changes in the brain, resulting in cognitive deficits. Only a few studies explored the contribution of non-coding genes in these pathophysiologies. Recently, we identified obesity-linked circular RNAs (circRNA) by analyzing the brain cortices of high-fat-fed obese mice. In this study, we scrutinized a conserved and neuron-specific circRNA, circTshz2-2, which affects neuronal cell cycle and spatial memory in the brain. Transcriptomic and cellular analysis indicated that circTshz2-2 dysregulation altered the expression of cell division-related genes and induced cell cycle arrest at the G2/M phase of the neuron. We found that circTshz2-2 bound to the YY1 transcriptional complex and suppressed
Bdnf
transcription. Suppression of circTshz2-2 increased BDNF expression and reduced G2/M checkpoint proteins such as Cyclin B2 and CDK1 through BDNF/TrkB signaling pathway, resulting in cell cycle arrest and neurite elongation. Inversely, overexpression of circTshz2-2 decreased BDNF expression, induced cell cycle proteins, and shortened the neurite length, indicating that circTshz2-2 regulates neuronal cell cycle and structure. Finally, we showed that circTshz2-2 affects spatial memory in wild-type and obese mice. Our data have revealed potential regulatory roles of obesity-related circTshz2-2 on the neuronal cell cycle and memory function providing a novel link between metabolic syndromes and cognitive deficits.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34561612</pmid><doi>10.1038/s41380-021-01303-x</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-9165-8507</orcidid><orcidid>https://orcid.org/0000-0001-6434-2235</orcidid><orcidid>https://orcid.org/0000-0001-8132-4389</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-4184 |
| ispartof | Molecular psychiatry, 2021-11, Vol.26 (11), p.6350-6364 |
| issn | 1359-4184 1476-5578 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8760052 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | 38/39 38/89 38/90 38/91 631/337 631/378 631/80 Animals Behavioral Sciences Biological Psychology Brain - metabolism Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cell cycle Cell Cycle Proteins - metabolism Cell Division Circular RNA Cognitive ability Genetic aspects Growth Health aspects Medicine Medicine & Public Health Memory Metabolic syndrome Mice Neurons Neurons - metabolism Neurosciences Non-coding RNA Obesity Obesity - genetics Pharmacotherapy Psychiatry RNA RNA, Circular - genetics Signal transduction Spatial Memory Transcription Transcriptomics TrkB receptors YY1 protein |
| title | Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T19%3A59%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Obesity-linked%20circular%20RNA%20circTshz2-2%20regulates%20the%20neuronal%20cell%20cycle%20and%20spatial%20memory%20in%20the%20brain&rft.jtitle=Molecular%20psychiatry&rft.au=Yoon,%20Gwangho&rft.date=2021-11-01&rft.volume=26&rft.issue=11&rft.spage=6350&rft.epage=6364&rft.pages=6350-6364&rft.issn=1359-4184&rft.eissn=1476-5578&rft_id=info:doi/10.1038/s41380-021-01303-x&rft_dat=%3Cgale_pubme%3EA691095297%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2619611112&rft_id=info:pmid/34561612&rft_galeid=A691095297&rfr_iscdi=true |