Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can exert antidepressant, anti-inflammatory and neuroprotective properties, but the exact molecular mechanism underlying their effects is still not fully understood. We conducted both in vitro and clinical investigations to test which EPA or...

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Veröffentlicht in:	Molecular psychiatry 2021-11, Vol.26 (11), p.6773-6788
Hauptverfasser:	Borsini, Alessandra, Nicolaou, Anna, Camacho-Muñoz, Dolores, Kendall, Alexandra C., Di Benedetto, Maria Grazia, Giacobbe, Juliette, Su, Kuan-Pin, Pariante, Carmine M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/106 13/2 13/21 13/51 14 14/35 38 38/77 631/337 631/378 631/80 Apoptosis Behavioral Sciences Biological Psychology Cytochrome P-450 Enzyme System - metabolism Cytochrome P-450 Enzyme System - pharmacology Cytochrome P-450 Enzyme System - therapeutic use Cytochrome P450 Cytokines Depression Depression, Mental Depressive Disorder, Major - drug therapy Docosahexaenoic acid Docosahexaenoic Acids - pharmacology Eicosapentaenoic acid Eicosapentaenoic Acid - pharmacology Eicosapentaenoic Acid - therapeutic use Fatty Acids, Omega-3 - metabolism Fatty Acids, Omega-3 - pharmacology Health aspects Hippocampus Hippocampus - metabolism Humans Hydroxylase Inflammation Inflammation - metabolism Interleukin 1 Interleukin 6 Lipids Lipoxygenase Lipoxygenase - metabolism Lipoxygenase - pharmacology Lipoxygenase - therapeutic use Mass spectroscopy Medicine Medicine & Public Health Mental depression Metabolites Neurogenesis Neuroprotection Neurosciences Omega-3 fatty acids Parahippocampal region Patients Pharmacotherapy Physiological aspects Polyunsaturated fatty acids Progenitor cells Psychiatry Psychological aspects Staphylococcal enterotoxin H Stem cells α-Interferon
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