ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition

ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 in 3 infants with multisystemic disease involving the liver and hematopoietic system. This entity has subsequently been documented in case reports and series to occupy a wider clinicopathologic spectrum with...

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Veröffentlicht in:	Blood 2022-01, Vol.139 (2), p.256-280
Hauptverfasser:	Kemps, Paul G., Picarsic, Jennifer, Durham, Benjamin H., Hélias-Rodzewicz, Zofia, Hiemcke-Jiwa, Laura, van den Bos, Cor, van de Wetering, Marianne D., van Noesel, Carel J.M., van Laar, Jan A.M., Verdijk, Robert M., Flucke, Uta E., Hogendoorn, Pancras C.W., Woei-A-Jin, F. J. Sherida H., Sciot, Raf, Beilken, Andreas, Feuerhake, Friedrich, Ebinger, Martin, Möhle, Robert, Fend, Falko, Bornemann, Antje, Wiegering, Verena, Ernestus, Karen, Méry, Tina, Gryniewicz-Kwiatkowska, Olga, Dembowska-Baginska, Bozenna, Evseev, Dmitry A., Potapenko, Vsevolod, Baykov, Vadim V., Gaspari, Stefania, Rossi, Sabrina, Gessi, Marco, Tamburrini, Gianpiero, Héritier, Sébastien, Donadieu, Jean, Bonneau-Lagacherie, Jacinthe, Lamaison, Claire, Farnault, Laure, Fraitag, Sylvie, Jullié, Marie-Laure, Haroche, Julien, Collin, Matthew, Allotey, Jackie, Madni, Majid, Turner, Kerry, Picton, Susan, Barbaro, Pasquale M., Poulin, Alysa, Tam, Ingrid S., El Demellawy, Dina, Empringham, Brianna, Whitlock, James A., Raghunathan, Aditya, Swanson, Amy A., Suchi, Mariko, Brandt, Jon M., Yaseen, Nabeel R., Weinstein, Joanna L., Eldem, Irem, Sisk, Bryan A., Sridhar, Vaishnavi, Atkinson, Mandy, Massoth, Lucas R., Hornick, Jason L., Alexandrescu, Sanda, Yeo, Kee Kiat, Petrova-Drus, Kseniya, Peeke, Stephen Z., Muñoz-Arcos, Laura S., Leino, Daniel G., Grier, David D., Lorsbach, Robert, Roy, Somak, Kumar, Ashish R., Garg, Shipra, Tiwari, Nishant, Schafernak, Kristian T., Henry, Michael M., van Halteren, Astrid G.S., Abla, Oussama, Diamond, Eli L., Emile, Jean-François
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anaplastic Lymphoma Kinase - analysis Anaplastic Lymphoma Kinase - antagonists & inhibitors Anaplastic Lymphoma Kinase - genetics Child Child, Preschool Female Histiocytic Disorders, Malignant - complications Histiocytic Disorders, Malignant - drug therapy Histiocytic Disorders, Malignant - genetics Histiocytic Disorders, Malignant - pathology Humans Infant Life Sciences Male Myeloid Neoplasia Nervous System Diseases - etiology Nervous System Diseases - genetics Nervous System Diseases - pathology Oncogene Proteins, Fusion - analysis Oncogene Proteins, Fusion - antagonists & inhibitors Oncogene Proteins, Fusion - genetics Protein Kinase Inhibitors - therapeutic use Retrospective Studies Young Adult
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