Genetic correlation, pleiotropy, and causal associations between substance use and psychiatric disorder

Substance use occurs at a high rate in persons with a psychiatric disorder. Genetically informative studies have the potential to elucidate the etiology of these phenomena. Recent developments in genome-wide association studies (GWAS) allow new avenues of investigation. Using results of GWAS meta-an...

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Veröffentlicht in:	Psychological medicine 2022-04, Vol.52 (5), p.968-978
Hauptverfasser:	Jang, Seon-Kyeong, Saunders, Gretchen, Liu, MengZhen, Jiang, Yu, Liu, Dajiang J., Vrieze, Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol use Anorexia Attention deficit hyperactivity disorder Bipolar disorder Cannabis Causality Clathrin Drug use Etiology Factor analysis Gene loci Genetic analysis Genetic Pleiotropy Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Genomics Genotype & phenotype Humans Internalization Marijuana Mental disorders Mental Disorders - epidemiology Mental Disorders - genetics Morphogenesis Mortality Neurodevelopment Neurodevelopmental disorders Neurotransmission Original Article Phenotype Phenotypes Pleiotropy Polymorphism, Single Nucleotide Psychopathology Psychosis Schizophrenia Schizophrenia - epidemiology Schizophrenia - genetics Signal transduction Smoking Substance use Substance-Related Disorders - epidemiology Substance-Related Disorders - genetics Tobacco Trafficking
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