Activation of trace amine‐associated receptor 1 selectively attenuates the reinforcing effects of morphine

Background and Purpose Trace amine‐associated TA1 receptors play critical roles in regulating dopamine transmission. Previous studies showed that pharmacologically or genetically manipulating the activity of TA1 receptors modulates addiction‐like behaviours associated with psychostimulants. However,...

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Veröffentlicht in:	British journal of pharmacology 2021-02, Vol.178 (4), p.933-945
Hauptverfasser:	Liu, Jianfeng, Seaman, Robert, Johnson, Bernard, Wu, Ruyan, Vu, Jimmy, Tian, Jingwei, Zhang, Yanan, Li, Jun‐Xu
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Agonists analgesia Analgesics Animals Aversion Chronic pain Dose-Response Relationship, Drug Locomotor activity Male Mice Morphine Morphine Dependence Naltrexone Opioid receptors Pain perception Place preference conditioning Rats Receptor mechanisms Receptors, G-Protein-Coupled Reinforcement, Psychology reinforcing effects Reinstatement Rodents TA1 receptor Withdrawal
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