Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections

MV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. However, its mechanism of action remains poorly understood. Here, we find that intranasal prophylaxis with MV130 modulates the lung i...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-01, Vol.38 (1), p.110184-110184, Article 110184
Hauptverfasser:	Brandi, Paola, Conejero, Laura, Cueto, Francisco J, Martínez-Cano, Sarai, Dunphy, Gillian, Gómez, Manuel J, Relaño, Carlos, Saz-Leal, Paula, Enamorado, Michel, Quintas, Ana, Dopazo, Ana, Amores-Iniesta, Joaquín, Del Fresno, Carlos, Nistal-Villán, Estanislao, Ardavín, Carlos, Nieto, Antonio, Casanovas, Miguel, Subiza, José Luis, Sancho, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Antibodies, Viral - immunology Bacteria - immunology Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Candidiasis - prevention & control Cell Line Chlorocebus aethiops Cytokines - biosynthesis Humans Immunity, Mucosal - immunology Influenza A virus - immunology L Cells Lung - immunology Metformin - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Monocytes - immunology Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Respiratory Mucosa - immunology Respiratory Tract Infections - microbiology Respiratory Tract Infections - prevention & control Respiratory Tract Infections - virology Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology
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