Determinants and Trends of COVID-19 Vaccine Hesitancy and Vaccine Uptake in a National Cohort of US Adults: A Longitudinal Study
Abstract We estimated the trends and correlates of vaccine hesitancy and its association with subsequent vaccine uptake among 5,458 adults in the United States. Participants belonged to the Communities, Households, and SARS-CoV-2 Epidemiology COVID (CHASING COVID) Cohort, a national longitudinal stu...
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| Veröffentlicht in: | American journal of epidemiology 2022-03, Vol.191 (4), p.570-583 |
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| creator | Rane, Madhura S Kochhar, Shivani Poehlein, Emily You, William Robertson, McKaylee M Zimba, Rebecca Westmoreland, Drew A Romo, Matthew L Kulkarni, Sarah G Chang, Mindy Berry, Amanda Parcesepe, Angela M Maroko, Andrew R Grov, Christian Nash, Denis |
| description | Abstract
We estimated the trends and correlates of vaccine hesitancy and its association with subsequent vaccine uptake among 5,458 adults in the United States. Participants belonged to the Communities, Households, and SARS-CoV-2 Epidemiology COVID (CHASING COVID) Cohort, a national longitudinal study. Trends and correlates of vaccine hesitancy were examined longitudinally in 8 interview rounds from October 2020 to July 2021. We also estimated the association between willingness to vaccinate and subsequent vaccine uptake through July 2021. Vaccine delay and refusal decreased from 51% and 8% in October 2020 to 8% and 6% in July 2021, respectively. Compared with non-Hispanic (NH) White participants, NH Black and Hispanic participants had higher adjusted odds ratios (aOR) for both vaccine delay (for NH Black, aOR = 2.0 (95% confidence interval (CI): 1.5, 2.7), and for Hispanic, 1.3 (95% CI: 1.0, 1.7)) and vaccine refusal (for NH Black, aOR = 2.5 (95% CI: 1.8, 3.6), and for Hispanic, 1.4 (95% CI: 1.0, 2.0)) in June 2021. COVID-19 vaccine hesitancy, compared with vaccine-willingness, was associated with lower odds of subsequent vaccine uptake (for vaccine delayers, aOR = 0.15, 95% CI: 0.13, 0.18; for vaccine refusers, aOR = 0.02; 95% CI: 0.01, 0.03 ), adjusted for sociodemographic factors and COVID-19 history. Vaccination awareness and distribution efforts should focus on vaccine delayers. |
| doi_str_mv | 10.1093/aje/kwab293 |
| format | Article |
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We estimated the trends and correlates of vaccine hesitancy and its association with subsequent vaccine uptake among 5,458 adults in the United States. Participants belonged to the Communities, Households, and SARS-CoV-2 Epidemiology COVID (CHASING COVID) Cohort, a national longitudinal study. Trends and correlates of vaccine hesitancy were examined longitudinally in 8 interview rounds from October 2020 to July 2021. We also estimated the association between willingness to vaccinate and subsequent vaccine uptake through July 2021. Vaccine delay and refusal decreased from 51% and 8% in October 2020 to 8% and 6% in July 2021, respectively. Compared with non-Hispanic (NH) White participants, NH Black and Hispanic participants had higher adjusted odds ratios (aOR) for both vaccine delay (for NH Black, aOR = 2.0 (95% confidence interval (CI): 1.5, 2.7), and for Hispanic, 1.3 (95% CI: 1.0, 1.7)) and vaccine refusal (for NH Black, aOR = 2.5 (95% CI: 1.8, 3.6), and for Hispanic, 1.4 (95% CI: 1.0, 2.0)) in June 2021. COVID-19 vaccine hesitancy, compared with vaccine-willingness, was associated with lower odds of subsequent vaccine uptake (for vaccine delayers, aOR = 0.15, 95% CI: 0.13, 0.18; for vaccine refusers, aOR = 0.02; 95% CI: 0.01, 0.03 ), adjusted for sociodemographic factors and COVID-19 history. Vaccination awareness and distribution efforts should focus on vaccine delayers.</description><identifier>ISSN: 0002-9262</identifier><identifier>ISSN: 1476-6256</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwab293</identifier><identifier>PMID: 34999751</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adult ; Adults ; Cohort analysis ; Confidence intervals ; Coronaviruses ; COVID-19 - epidemiology ; COVID-19 - prevention & control ; COVID-19 Vaccines ; Epidemiology ; Hispanic people ; Households ; Humans ; Longitudinal Studies ; Original Contribution ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Trends ; United States - epidemiology ; Vaccination ; Vaccination Hesitancy ; Vaccines</subject><ispartof>American journal of epidemiology, 2022-03, Vol.191 (4), p.570-583</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-5957e64d47e4eb57953ba4089e6d692e97b147bb455b2a3c1b2346059b0d3b983</citedby><cites>FETCH-LOGICAL-c440t-5957e64d47e4eb57953ba4089e6d692e97b147bb455b2a3c1b2346059b0d3b983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34999751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rane, Madhura S</creatorcontrib><creatorcontrib>Kochhar, Shivani</creatorcontrib><creatorcontrib>Poehlein, Emily</creatorcontrib><creatorcontrib>You, William</creatorcontrib><creatorcontrib>Robertson, McKaylee M</creatorcontrib><creatorcontrib>Zimba, Rebecca</creatorcontrib><creatorcontrib>Westmoreland, Drew A</creatorcontrib><creatorcontrib>Romo, Matthew L</creatorcontrib><creatorcontrib>Kulkarni, Sarah G</creatorcontrib><creatorcontrib>Chang, Mindy</creatorcontrib><creatorcontrib>Berry, Amanda</creatorcontrib><creatorcontrib>Parcesepe, Angela M</creatorcontrib><creatorcontrib>Maroko, Andrew R</creatorcontrib><creatorcontrib>Grov, Christian</creatorcontrib><creatorcontrib>Nash, Denis</creatorcontrib><creatorcontrib>CHASING COVID Cohort Study Team</creatorcontrib><creatorcontrib>for the CHASING COVID Cohort Study Team</creatorcontrib><title>Determinants and Trends of COVID-19 Vaccine Hesitancy and Vaccine Uptake in a National Cohort of US Adults: A Longitudinal Study</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Abstract
We estimated the trends and correlates of vaccine hesitancy and its association with subsequent vaccine uptake among 5,458 adults in the United States. Participants belonged to the Communities, Households, and SARS-CoV-2 Epidemiology COVID (CHASING COVID) Cohort, a national longitudinal study. Trends and correlates of vaccine hesitancy were examined longitudinally in 8 interview rounds from October 2020 to July 2021. We also estimated the association between willingness to vaccinate and subsequent vaccine uptake through July 2021. Vaccine delay and refusal decreased from 51% and 8% in October 2020 to 8% and 6% in July 2021, respectively. Compared with non-Hispanic (NH) White participants, NH Black and Hispanic participants had higher adjusted odds ratios (aOR) for both vaccine delay (for NH Black, aOR = 2.0 (95% confidence interval (CI): 1.5, 2.7), and for Hispanic, 1.3 (95% CI: 1.0, 1.7)) and vaccine refusal (for NH Black, aOR = 2.5 (95% CI: 1.8, 3.6), and for Hispanic, 1.4 (95% CI: 1.0, 2.0)) in June 2021. COVID-19 vaccine hesitancy, compared with vaccine-willingness, was associated with lower odds of subsequent vaccine uptake (for vaccine delayers, aOR = 0.15, 95% CI: 0.13, 0.18; for vaccine refusers, aOR = 0.02; 95% CI: 0.01, 0.03 ), adjusted for sociodemographic factors and COVID-19 history. Vaccination awareness and distribution efforts should focus on vaccine delayers.</description><subject>Adult</subject><subject>Adults</subject><subject>Cohort analysis</subject><subject>Confidence intervals</subject><subject>Coronaviruses</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - prevention & control</subject><subject>COVID-19 Vaccines</subject><subject>Epidemiology</subject><subject>Hispanic people</subject><subject>Households</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Original Contribution</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Trends</subject><subject>United States - epidemiology</subject><subject>Vaccination</subject><subject>Vaccination Hesitancy</subject><subject>Vaccines</subject><issn>0002-9262</issn><issn>1476-6256</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90c1rFDEYBvAgil2rJ-8SEESQsfmeiQdh2aotLPbQbq8hmXm3zXY2WZOMsjf_dGfdbVEPnhKSHw_vy4PQS0reU6L5iV3Byd0P65jmj9CEilpVikn1GE0IIazSTLEj9CznFSGUakmeoiMutNa1pBP08xQKpLUPNpSMbejwVYLQZRyXeHZxfX5aUY2vbdv6APgMsi82tNvf8P51sSn2DrAP2OKvtvgYbI9n8TamsktZXOJpN_Qlf8BTPI_hxpeh8ztzOV62z9GTpe0zvDicx2jx-dPV7KyaX3w5n03nVSsEKZXUsgYlOlGDACdrLbmzgjQaVKc0A127cXPnhJSOWd5Sx7hQRGpHOu50w4_Rx33uZnBr6FoIJdnebJJf27Q10Xrz90_wt-YmfjdNLSXXYgx4ewhI8dsAuZi1zy30vQ0Qh2yYoo1kXJN6pK__oas4pHHlnRKaKtYQOap3e9WmmHOC5cMwlJhds2Zs1hyaHfWrP-d_sPdVjuDNHsRh89-kXxFTrCQ</recordid><startdate>20220324</startdate><enddate>20220324</enddate><creator>Rane, Madhura S</creator><creator>Kochhar, Shivani</creator><creator>Poehlein, Emily</creator><creator>You, William</creator><creator>Robertson, McKaylee M</creator><creator>Zimba, Rebecca</creator><creator>Westmoreland, Drew A</creator><creator>Romo, Matthew L</creator><creator>Kulkarni, Sarah G</creator><creator>Chang, Mindy</creator><creator>Berry, Amanda</creator><creator>Parcesepe, Angela M</creator><creator>Maroko, Andrew R</creator><creator>Grov, Christian</creator><creator>Nash, Denis</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220324</creationdate><title>Determinants and Trends of COVID-19 Vaccine Hesitancy and Vaccine Uptake in a National Cohort of US Adults: A Longitudinal Study</title><author>Rane, Madhura S ; 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We estimated the trends and correlates of vaccine hesitancy and its association with subsequent vaccine uptake among 5,458 adults in the United States. Participants belonged to the Communities, Households, and SARS-CoV-2 Epidemiology COVID (CHASING COVID) Cohort, a national longitudinal study. Trends and correlates of vaccine hesitancy were examined longitudinally in 8 interview rounds from October 2020 to July 2021. We also estimated the association between willingness to vaccinate and subsequent vaccine uptake through July 2021. Vaccine delay and refusal decreased from 51% and 8% in October 2020 to 8% and 6% in July 2021, respectively. Compared with non-Hispanic (NH) White participants, NH Black and Hispanic participants had higher adjusted odds ratios (aOR) for both vaccine delay (for NH Black, aOR = 2.0 (95% confidence interval (CI): 1.5, 2.7), and for Hispanic, 1.3 (95% CI: 1.0, 1.7)) and vaccine refusal (for NH Black, aOR = 2.5 (95% CI: 1.8, 3.6), and for Hispanic, 1.4 (95% CI: 1.0, 2.0)) in June 2021. COVID-19 vaccine hesitancy, compared with vaccine-willingness, was associated with lower odds of subsequent vaccine uptake (for vaccine delayers, aOR = 0.15, 95% CI: 0.13, 0.18; for vaccine refusers, aOR = 0.02; 95% CI: 0.01, 0.03 ), adjusted for sociodemographic factors and COVID-19 history. Vaccination awareness and distribution efforts should focus on vaccine delayers.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>34999751</pmid><doi>10.1093/aje/kwab293</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Adults Cohort analysis Confidence intervals Coronaviruses COVID-19 - epidemiology COVID-19 - prevention & control COVID-19 Vaccines Epidemiology Hispanic people Households Humans Longitudinal Studies Original Contribution SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Trends United States - epidemiology Vaccination Vaccination Hesitancy Vaccines |
| title | Determinants and Trends of COVID-19 Vaccine Hesitancy and Vaccine Uptake in a National Cohort of US Adults: A Longitudinal Study |
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