A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells

Objective The interleukin (IL)-12 cytokine family is closely related to the development of T helper cells, which are responsible for autoimmune disease enhancement or suppression. IL-12 family members are generally heterodimers and share three α-subunits (p35, p19, and p28) and two β-subunits (p40 a...

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Veröffentlicht in:	Cellular & molecular immunology 2022-01, Vol.19 (1), p.79-91
Hauptverfasser:	Lee, Seon-Yeong, Moon, Su-Jin, Moon, Young-Mee, Seo, Hyeon-Beom, Ryu, Jun-Geol, Lee, A Ram, Lee, Chae Rim, Kim, Da-Som, Her, Yang-Mi, Choi, Jeong Won, Kwok, Seung-Ki, Park, Sung-Hwan, Cho, Mi-La
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127 631/250/38 Animals Antibodies Arthritis Arthritis, Experimental Autoimmune Diseases Biomedical and Life Sciences Biomedicine CD25 antigen CD4 antigen Cell differentiation Collagen Cytokines Cytokines - therapeutic use Enzyme-linked immunosorbent assay Fc receptors Foxp3 protein Gene expression Helper cells IL-1β Immune response Immunology Immunoprecipitation Immunoregulation Inflammation Interleukin 12 Interleukin 17 Interleukin 23 Interleukin 6 Interleukin-12 - chemistry Interleukin-12 - metabolism Lymphocytes T Medical Microbiology Mice Microbiology Minor Histocompatibility Antigens Osteoclastogenesis Proteins Receptors, Cytokine - genetics Receptors, Cytokine - therapeutic use T-Lymphocytes, Regulatory Th17 Cells Tumor necrosis factor-α Vaccine Western blotting
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