GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation

Purpose This study aimed to retrospectively evaluate the genetic association of null variants of glutathione S-transferases GSTM1 and GSTT1 with relapse incidence in children with hematological malignancies (HMs) undergoing busulfan (BU)- containing allogeneic hematopoietic stem cell transplantation...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2022-01, Vol.148 (1), p.71-86
Hauptverfasser:	Jurkovic Mlakar, Simona, Uppugunduri, Satyanarayana Chakradhara Rao, Nava, Tiago, Mlakar, Vid, Golay, Hadrien, Robin, Shannon, Waespe, Nicolas, Rezgui, Mohamed Aziz, Chalandon, Yves, Boelens, Jaap Jan, Bredius, Robert G. M., Dalle, Jean-Hugues, Peters, Christina, Corbacioglu, Selim, Bittencourt, Henrique, Krajinovic, Maja, Ansari, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Apoptosis Biomarkers, Tumor - genetics Busulfan Busulfan - therapeutic use Cancer Research Cell culture Cell death Cell fate Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Child Child, Preschool Children CRISPR Cytotoxicity Drug Resistance, Neoplasm - genetics Female Gene Deletion Genetic Predisposition to Disease - genetics Genotype Genotypes Glutathione Glutathione - analysis Glutathione - metabolism Glutathione Transferase - genetics GSTM1 protein GSTT1 protein Hematologic Neoplasms - genetics Hematologic Neoplasms - pathology Hematologic Neoplasms - therapy Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Infant Internal Medicine Leukemia - genetics Leukemia - pathology Leukemia - therapy Lymphoblastoid cell lines Male Medicine Medicine & Public Health NCT NCT01257854 Neoplasm Recurrence, Local - genetics Null cells Oncology Original Article – Cancer Research Original – Cancer Research Retrospective Studies Risk Factors Stem cell transplantation Tumor cell lines Tumors
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