Determinants of early antibody responses to COVID-19 mRNA vaccines in a cohort of exposed and naïve healthcare workers

Two doses of mRNA vaccination have shown >94% efficacy at preventing COVID-19 mostly in naïve adults, but it is not clear if the second dose is needed to maximize effectiveness in those previously exposed to SARS-CoV-2 and what other factors affect responsiveness. We measured IgA, IgG and IgM lev...

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Veröffentlicht in:	EBioMedicine 2022-01, Vol.75, p.103805, Article 103805
Hauptverfasser:	Moncunill, Gemma, Aguilar, Ruth, Ribes, Marta, Ortega, Natalia, Rubio, Rocío, Salmerón, Gemma, Molina, María José, Vidal, Marta, Barrios, Diana, Mitchell, Robert A., Jiménez, Alfons, Castellana, Cristina, Hernández-Luis, Pablo, Rodó, Pau, Méndez, Susana, Llupià, Anna, Puyol, Laura, Rodrigo Melero, Natalia, Carolis, Carlo, Mayor, Alfredo, Izquierdo, Luis, Varela, Pilar, Trilla, Antoni, Vilella, Anna, Barroso, Sonia, Angulo, Ana, Engel, Pablo, Tortajada, Marta, García-Basteiro, Alberto L., Dobaño, Carlota
Format:	Artikel
Sprache:	eng
Schlagworte:	2019-nCoV Vaccine mRNA-1273 - administration & dosage 2019-nCoV Vaccine mRNA-1273 - immunology Adult Antibodies, Viral - immunology Antibody Antibody Formation - drug effects Avidity BNT162 Vaccine - administration & dosage BNT162 Vaccine - immunology Coronavirus Nucleocapsid Proteins - immunology COVID-19 COVID-19 - epidemiology COVID-19 - immunology COVID-19 - prevention & control Female Health care workers Health Personnel Humans Immunogenicity, Vaccine Immunoglobulin A - immunology Immunoglobulin G - immunology Male Middle Aged mRNA vaccines Neutralization Phosphoproteins - immunology SARS-CoV-2 SARS-CoV-2 - immunology Spike Glycoprotein, Coronavirus - immunology
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