Correlation Analysis of Acute Coronary Syndrome with Serum IL-18, MMP-9, hs-CRP, and Plasma FIB
Aim. This study attempted to investigate the diagnostic value of interleukin-18 (IL-18), matrix metalloproteinase-9 (MMP-9), high-sensitivity C-reactive protein (hs-CRP), and fibrinogen (FIB) in acute coronary syndrome (ACS) and their correlation with the degree of vascular lesions. Materials and Me...
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| description | Aim. This study attempted to investigate the diagnostic value of interleukin-18 (IL-18), matrix metalloproteinase-9 (MMP-9), high-sensitivity C-reactive protein (hs-CRP), and fibrinogen (FIB) in acute coronary syndrome (ACS) and their correlation with the degree of vascular lesions. Materials and Methods. Altogether 206 patients with coronary heart disease admitted to our hospital were selected as research objects, including 136 patients with ACS (group A), 70 patients with stable angina pectoris (SAP) (group B), and 60 patients with noncoronary heart disease who had normal coronary angiography during the same period were selected as group C. The levels of IL-18, MMP-9, and hs-CRP in the serum were detected by enzyme-linked immunosorbent assay (ELISA), and the level of FIB in plasma was detected by automatic coagulation analyzer. Results. Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels in group A were significantly higher than those in group B and group C (p |
| doi_str_mv | 10.1155/2022/5984184 |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8752213</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A697663163</galeid><sourcerecordid>A697663163</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-2d9b8e1cf761557802b313b95abb9240dabc30a9777b008d799a7109ab935da33</originalsourceid><addsrcrecordid>eNp9kc1r2zAYh83YWEvb285DsMtgcasP6-syyMLaBVIW1u0sJFtuVGypleyV_PeVSZZtPVQXCd6H531f_YriHYLnCFF6gSHGF1SKConqVXGMCapKhir0-vAm5Kg4S-kO5iMQg5K9LY4IhVgQRI8LtQgx2k4PLngw97rbJpdAaMG8HgcLcjV4HbfgZuubGHoLHt2wATc2jj1YrkokZuD6el3KGdikcvFjPQPaN2Dd6dRrcLn8clq8aXWX7Nn-Pil-XX79ufhWrr5fLRfzVVlXnA0lbqQRFtUtZ3ktLiA2BBEjqTZG4go22tQEask5N3mPhkupOYJSG0loowk5KT7vvPej6W1TWz9E3an76Po8vgraqf8r3m3UbfitBKcYo0nwcS-I4WG0aVC9S7XtOu1tGJPCDEPIBaUyox-eoXdhjPnvJgpJSbOO_aVudWeV823IfetJquZMcsYIYlPb2Y6qY0gp2vYwMoJqilhNEat9xBl__--aB_hPoBn4tAM2zjf60b2sewIMZKkq</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2619951336</pqid></control><display><type>article</type><title>Correlation Analysis of Acute Coronary Syndrome with Serum IL-18, MMP-9, hs-CRP, and Plasma FIB</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Yang, Yuexia ; Li, Guoming ; Zhang, Ruiqin</creator><contributor>Yang, Jun ; Jun Yang</contributor><creatorcontrib>Yang, Yuexia ; Li, Guoming ; Zhang, Ruiqin ; Yang, Jun ; Jun Yang</creatorcontrib><description>Aim. This study attempted to investigate the diagnostic value of interleukin-18 (IL-18), matrix metalloproteinase-9 (MMP-9), high-sensitivity C-reactive protein (hs-CRP), and fibrinogen (FIB) in acute coronary syndrome (ACS) and their correlation with the degree of vascular lesions. Materials and Methods. Altogether 206 patients with coronary heart disease admitted to our hospital were selected as research objects, including 136 patients with ACS (group A), 70 patients with stable angina pectoris (SAP) (group B), and 60 patients with noncoronary heart disease who had normal coronary angiography during the same period were selected as group C. The levels of IL-18, MMP-9, and hs-CRP in the serum were detected by enzyme-linked immunosorbent assay (ELISA), and the level of FIB in plasma was detected by automatic coagulation analyzer. Results. Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels in group A were significantly higher than those in group B and group C (p<0.05). ROC curve and multivariate logistic regression showed that the sensitivity and specificity of combined diagnosis of ACS with serum IL-18, MMP-9, hs-CRP, and plasma FIB were 86.03% and 95.71%, respectively. Serum IL-18, MMP-9, hs-CRP, and plasma FIB were positively correlated with Gensini grading (p<0.001). Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels were positively correlated (p<0.001). Conclusion. The combined detection of serum IL-18, MMP-9, hs-CRP, and plasma FIB has good diagnostic value for ACS, and these index levels are positively correlated with the degree of vascular lesions.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2022/5984184</identifier><identifier>PMID: 35028315</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Acute coronary syndrome ; Acute Coronary Syndrome - blood ; Acute Coronary Syndrome - diagnostic imaging ; Acute coronary syndromes ; Aged ; Angina ; Angina pectoris ; Angiography ; C-reactive protein ; C-Reactive Protein - metabolism ; Cardiovascular disease ; Cardiovascular diseases ; Coagulation ; Coronary Angiography ; Coronary artery disease ; Correlation analysis ; Development and progression ; Diagnosis ; Diagnostic systems ; Enzyme-linked immunosorbent assay ; Female ; Fibrinogen ; Fibrinogen - metabolism ; Gelatinase B ; Health aspects ; Heart diseases ; Humans ; Interleukin 18 ; Interleukin-18 - blood ; Interleukins ; Lesions ; Male ; Matrix metalloproteinase ; Matrix Metalloproteinase 9 - blood ; Matrix metalloproteinases ; Measurement ; Medical imaging ; Metalloenzymes ; Metalloproteinase ; Middle Aged ; Mortality ; Patients ; Physiological aspects ; Sensitivity</subject><ispartof>BioMed research international, 2022, Vol.2022 (1), p.5984184-5984184</ispartof><rights>Copyright © 2022 Yuexia Yang et al.</rights><rights>COPYRIGHT 2022 John Wiley & Sons, Inc.</rights><rights>Copyright © 2022 Yuexia Yang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Yuexia Yang et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-2d9b8e1cf761557802b313b95abb9240dabc30a9777b008d799a7109ab935da33</citedby><cites>FETCH-LOGICAL-c476t-2d9b8e1cf761557802b313b95abb9240dabc30a9777b008d799a7109ab935da33</cites><orcidid>0000-0002-9558-9115</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752213/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8752213/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35028315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yang, Jun</contributor><contributor>Jun Yang</contributor><creatorcontrib>Yang, Yuexia</creatorcontrib><creatorcontrib>Li, Guoming</creatorcontrib><creatorcontrib>Zhang, Ruiqin</creatorcontrib><title>Correlation Analysis of Acute Coronary Syndrome with Serum IL-18, MMP-9, hs-CRP, and Plasma FIB</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Aim. This study attempted to investigate the diagnostic value of interleukin-18 (IL-18), matrix metalloproteinase-9 (MMP-9), high-sensitivity C-reactive protein (hs-CRP), and fibrinogen (FIB) in acute coronary syndrome (ACS) and their correlation with the degree of vascular lesions. Materials and Methods. Altogether 206 patients with coronary heart disease admitted to our hospital were selected as research objects, including 136 patients with ACS (group A), 70 patients with stable angina pectoris (SAP) (group B), and 60 patients with noncoronary heart disease who had normal coronary angiography during the same period were selected as group C. The levels of IL-18, MMP-9, and hs-CRP in the serum were detected by enzyme-linked immunosorbent assay (ELISA), and the level of FIB in plasma was detected by automatic coagulation analyzer. Results. Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels in group A were significantly higher than those in group B and group C (p<0.05). ROC curve and multivariate logistic regression showed that the sensitivity and specificity of combined diagnosis of ACS with serum IL-18, MMP-9, hs-CRP, and plasma FIB were 86.03% and 95.71%, respectively. Serum IL-18, MMP-9, hs-CRP, and plasma FIB were positively correlated with Gensini grading (p<0.001). Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels were positively correlated (p<0.001). Conclusion. The combined detection of serum IL-18, MMP-9, hs-CRP, and plasma FIB has good diagnostic value for ACS, and these index levels are positively correlated with the degree of vascular lesions.</description><subject>Acute coronary syndrome</subject><subject>Acute Coronary Syndrome - blood</subject><subject>Acute Coronary Syndrome - diagnostic imaging</subject><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Angina</subject><subject>Angina pectoris</subject><subject>Angiography</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Coagulation</subject><subject>Coronary Angiography</subject><subject>Coronary artery disease</subject><subject>Correlation analysis</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Fibrinogen</subject><subject>Fibrinogen - metabolism</subject><subject>Gelatinase B</subject><subject>Health aspects</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Interleukin 18</subject><subject>Interleukin-18 - blood</subject><subject>Interleukins</subject><subject>Lesions</subject><subject>Male</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Matrix metalloproteinases</subject><subject>Measurement</subject><subject>Medical imaging</subject><subject>Metalloenzymes</subject><subject>Metalloproteinase</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Sensitivity</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1r2zAYh83YWEvb285DsMtgcasP6-syyMLaBVIW1u0sJFtuVGypleyV_PeVSZZtPVQXCd6H531f_YriHYLnCFF6gSHGF1SKConqVXGMCapKhir0-vAm5Kg4S-kO5iMQg5K9LY4IhVgQRI8LtQgx2k4PLngw97rbJpdAaMG8HgcLcjV4HbfgZuubGHoLHt2wATc2jj1YrkokZuD6el3KGdikcvFjPQPaN2Dd6dRrcLn8clq8aXWX7Nn-Pil-XX79ufhWrr5fLRfzVVlXnA0lbqQRFtUtZ3ktLiA2BBEjqTZG4go22tQEask5N3mPhkupOYJSG0loowk5KT7vvPej6W1TWz9E3an76Po8vgraqf8r3m3UbfitBKcYo0nwcS-I4WG0aVC9S7XtOu1tGJPCDEPIBaUyox-eoXdhjPnvJgpJSbOO_aVudWeV823IfetJquZMcsYIYlPb2Y6qY0gp2vYwMoJqilhNEat9xBl__--aB_hPoBn4tAM2zjf60b2sewIMZKkq</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Yang, Yuexia</creator><creator>Li, Guoming</creator><creator>Zhang, Ruiqin</creator><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9558-9115</orcidid></search><sort><creationdate>2022</creationdate><title>Correlation Analysis of Acute Coronary Syndrome with Serum IL-18, MMP-9, hs-CRP, and Plasma FIB</title><author>Yang, Yuexia ; Li, Guoming ; Zhang, Ruiqin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-2d9b8e1cf761557802b313b95abb9240dabc30a9777b008d799a7109ab935da33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acute coronary syndrome</topic><topic>Acute Coronary Syndrome - blood</topic><topic>Acute Coronary Syndrome - diagnostic imaging</topic><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Angina</topic><topic>Angina pectoris</topic><topic>Angiography</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Coagulation</topic><topic>Coronary Angiography</topic><topic>Coronary artery disease</topic><topic>Correlation analysis</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Fibrinogen</topic><topic>Fibrinogen - metabolism</topic><topic>Gelatinase B</topic><topic>Health aspects</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Interleukin 18</topic><topic>Interleukin-18 - blood</topic><topic>Interleukins</topic><topic>Lesions</topic><topic>Male</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Matrix metalloproteinases</topic><topic>Measurement</topic><topic>Medical imaging</topic><topic>Metalloenzymes</topic><topic>Metalloproteinase</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Sensitivity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Yuexia</creatorcontrib><creatorcontrib>Li, Guoming</creatorcontrib><creatorcontrib>Zhang, Ruiqin</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Yuexia</au><au>Li, Guoming</au><au>Zhang, Ruiqin</au><au>Yang, Jun</au><au>Jun Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation Analysis of Acute Coronary Syndrome with Serum IL-18, MMP-9, hs-CRP, and Plasma FIB</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><issue>1</issue><spage>5984184</spage><epage>5984184</epage><pages>5984184-5984184</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Aim. This study attempted to investigate the diagnostic value of interleukin-18 (IL-18), matrix metalloproteinase-9 (MMP-9), high-sensitivity C-reactive protein (hs-CRP), and fibrinogen (FIB) in acute coronary syndrome (ACS) and their correlation with the degree of vascular lesions. Materials and Methods. Altogether 206 patients with coronary heart disease admitted to our hospital were selected as research objects, including 136 patients with ACS (group A), 70 patients with stable angina pectoris (SAP) (group B), and 60 patients with noncoronary heart disease who had normal coronary angiography during the same period were selected as group C. The levels of IL-18, MMP-9, and hs-CRP in the serum were detected by enzyme-linked immunosorbent assay (ELISA), and the level of FIB in plasma was detected by automatic coagulation analyzer. Results. Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels in group A were significantly higher than those in group B and group C (p<0.05). ROC curve and multivariate logistic regression showed that the sensitivity and specificity of combined diagnosis of ACS with serum IL-18, MMP-9, hs-CRP, and plasma FIB were 86.03% and 95.71%, respectively. Serum IL-18, MMP-9, hs-CRP, and plasma FIB were positively correlated with Gensini grading (p<0.001). Serum IL-18, MMP-9, hs-CRP, and plasma FIB levels were positively correlated (p<0.001). Conclusion. The combined detection of serum IL-18, MMP-9, hs-CRP, and plasma FIB has good diagnostic value for ACS, and these index levels are positively correlated with the degree of vascular lesions.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35028315</pmid><doi>10.1155/2022/5984184</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9558-9115</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute coronary syndrome Acute Coronary Syndrome - blood Acute Coronary Syndrome - diagnostic imaging Acute coronary syndromes Aged Angina Angina pectoris Angiography C-reactive protein C-Reactive Protein - metabolism Cardiovascular disease Cardiovascular diseases Coagulation Coronary Angiography Coronary artery disease Correlation analysis Development and progression Diagnosis Diagnostic systems Enzyme-linked immunosorbent assay Female Fibrinogen Fibrinogen - metabolism Gelatinase B Health aspects Heart diseases Humans Interleukin 18 Interleukin-18 - blood Interleukins Lesions Male Matrix metalloproteinase Matrix Metalloproteinase 9 - blood Matrix metalloproteinases Measurement Medical imaging Metalloenzymes Metalloproteinase Middle Aged Mortality Patients Physiological aspects Sensitivity |
| title | Correlation Analysis of Acute Coronary Syndrome with Serum IL-18, MMP-9, hs-CRP, and Plasma FIB |
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