17-α-Estradiol Has Sex-Specific Effects on Neuroinflammation That Are Partly Reversed by Gonadectomy

Abstract 17-α-Estradiol (17aE2) treatment from 4 months of age extends life span in male mice and can reduce neuroinflammatory responses in the hypothalamus of 12-month-old males. Although 17aE2 improves longevity in males, female mice are unaffected, suggesting a sexually dimorphic pattern of life-...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2022-01, Vol.77 (1), p.66-74
Hauptverfasser:	Debarba, Lucas K, Jayarathne, Hashan S M, Miller, Richard A, Garratt, Michael, Sadagurski, Marianna
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Aging Animals Castration Castration - methods Estradiol - pharmacology Estrogen receptors Female Gliosis Gonadectomy Gonads Hypothalamus Inflammation Life span Longevity Male Males Medical research Medical treatment Mice Neuroinflammatory Diseases Sex Characteristics Sexual dimorphism THE JOURNAL OF GERONTOLOGY: Biological Sciences
Online-Zugang:	Volltext
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