Neutrophil Extracellular Traps Are Increased in Chronic Myeloid Leukemia and Are Differentially Affected by Tyrosine Kinase Inhibitors

Cardiovascular complications are increasingly reported with the use of certain tyrosine kinase inhibitors (TKIs) to treat chronic myeloid leukemia (CML). We studied neutrophil extracellular trap (NET) formation in CML and evaluated the effect of TKIs on NET formation. Neutrophils isolated from treat...

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Veröffentlicht in:	Cancers 2021-12, Vol.14 (1), p.119
Hauptverfasser:	Telerman, Alona, Granot, Galit, Leibovitch, Chiya, Yarchovsky-Dolberg, Osnat, Shacham-Abulafia, Adi, Partouche, Shirly, Yeshurun, Moshe, Ellis, Martin H, Raanani, Pia, Wolach, Ofir
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Arginine deiminase Chronic myeloid leukemia Citrulline Elastase Estrogens Gender Hemopoiesis Histone H3 Histones Ionomycin Leukemia Leukocytes (neutrophilic) Microscopy Morphology Myeloid leukemia Neutrophils Patients Peroxidase Phorbol 12-myristate 13-acetate Progenitor cells Protein-arginine deiminase Reactive oxygen species Thrombosis Toxicity Tyrosine kinase inhibitors
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