Identification of Neoantigens in Two Murine Gastric Cancer Cell Lines Leading to the Neoantigen-Based Immunotherapy

To develop combination immunotherapies for gastric cancers, immunologically well-characterized preclinical models are crucial. Here, we leveraged two transplantable murine gastric cancer cell lines, YTN2 and YTN16, derived from the same parental line but differing in their susceptibility to immune r...

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Veröffentlicht in:	Cancers 2021-12, Vol.14 (1), p.106
Hauptverfasser:	Nagaoka, Koji, Sun, Changbo, Kobayashi, Yukari, Kanaseki, Takayuki, Tokita, Serina, Komatsu, Toshihiro, Maejima, Kazuhiro, Futami, Junichiro, Nomura, Sachiyo, Udaka, Keiko, Nakagawa, Hidewaki, Torigoe, Toshihiko, Kakimi, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Cancer therapies CD8 antigen CTLA-4 protein Dendritic cells Gastric cancer Gene expression Immune checkpoint inhibitors Immunotherapy Lymphocytes T Major histocompatibility complex Monoclonal antibodies Mutation Neoantigens PD-1 protein PD-L1 protein Peptides Tumor cell lines Tumor cells
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