Trajectories of antenatal depression and adverse pregnancy outcomes
Antenatal depression affects approximately 1 of 7 pregnancies, with an increasing prevalence across gestation. Data regarding the associations between antenatal depression and adverse pregnancy outcomes yielded conflicting results. However, previous studies evaluated the cross-sectional prevalence o...
Gespeichert in:
| Veröffentlicht in: | American journal of obstetrics and gynecology 2022-01, Vol.226 (1), p.108.e1-108.e9 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 108.e9 |
|---|---|
| container_issue | 1 |
| container_start_page | 108.e1 |
| container_title | American journal of obstetrics and gynecology |
| container_volume | 226 |
| creator | Miller, Emily S. Saade, George R. Simhan, Hyagriv N. Monk, Catherine Haas, David M. Silver, Robert M. Mercer, Brian M. Parry, Samuel Wing, Deborah A. Reddy, Uma M. Grobman, William A. |
| description | Antenatal depression affects approximately 1 of 7 pregnancies, with an increasing prevalence across gestation. Data regarding the associations between antenatal depression and adverse pregnancy outcomes yielded conflicting results. However, previous studies evaluated the cross-sectional prevalence of depression at various time points and not the depressive symptom trajectory across gestation.
This study aimed to identify whether the trajectory of antenatal depressive symptoms is associated with different risks of adverse pregnancy outcomes.
This was a secondary analysis of a large multisite prospective cohort of nulliparous women across the United States. The Edinburgh Postpartum Depression Scale was administered at 2 study visits: between 6 and 14 weeks’ gestation and between 22 and 30 weeks’ gestation. The Edinburgh Postpartum Depression Scale score trajectories were categorized as improved, stable, or worsened based on whether the scores changed by at least 1 standard deviation between the 2 visits. The frequencies of adverse pregnancy outcomes (hypertensive disorders of pregnancy, abruption, cesarean delivery, preterm birth [ie, |
| doi_str_mv | 10.1016/j.ajog.2021.07.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8748269</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002937821007936</els_id><sourcerecordid>2553523106</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-6f96782e6bf7c1ffa3e840737c5e79518940c5902bd4cf9dde86d94b745257c93</originalsourceid><addsrcrecordid>eNp9kU2LFDEQhoMo7uzqH_AgffTSbSXpfIEIMugqLHhZzyGTVI9pepIx6RnYf283sy568VRU1VtvFU8R8oZCR4HK92PnxrzvGDDageoA1DOyoWBUK7XUz8kGAFhruNJX5LrWcU2ZYS_JFe-ZBq75hmzvixvRz7lErE0eGpdmTG52UxPwWLDWmNNSDI0LZywVm6W4Ty75hyafZp8PWF-RF4ObKr5-jDfkx5fP99uv7d3322_bT3et74WYWzkYqTRDuRuUp8PgOOoeFFdeoDKCatODFwbYLvR-MCGglsH0O9ULJpQ3_IZ8vPgeT7sDBo9pLm6yxxIPrjzY7KL9t5PiT7vPZ6tVr5lcDd49GpT864R1todYPU6TS5hP1TIhuGCcglyk7CL1JddacHhaQ8Gu9O1oV_p2pW9B2YX-MvT27wOfRv7gXgQfLgJcMJ0jFlt9xOQxxLI8wYYc_-f_G00bl6E</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2553523106</pqid></control><display><type>article</type><title>Trajectories of antenatal depression and adverse pregnancy outcomes</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Miller, Emily S. ; Saade, George R. ; Simhan, Hyagriv N. ; Monk, Catherine ; Haas, David M. ; Silver, Robert M. ; Mercer, Brian M. ; Parry, Samuel ; Wing, Deborah A. ; Reddy, Uma M. ; Grobman, William A.</creator><creatorcontrib>Miller, Emily S. ; Saade, George R. ; Simhan, Hyagriv N. ; Monk, Catherine ; Haas, David M. ; Silver, Robert M. ; Mercer, Brian M. ; Parry, Samuel ; Wing, Deborah A. ; Reddy, Uma M. ; Grobman, William A.</creatorcontrib><description>Antenatal depression affects approximately 1 of 7 pregnancies, with an increasing prevalence across gestation. Data regarding the associations between antenatal depression and adverse pregnancy outcomes yielded conflicting results. However, previous studies evaluated the cross-sectional prevalence of depression at various time points and not the depressive symptom trajectory across gestation.
This study aimed to identify whether the trajectory of antenatal depressive symptoms is associated with different risks of adverse pregnancy outcomes.
This was a secondary analysis of a large multisite prospective cohort of nulliparous women across the United States. The Edinburgh Postpartum Depression Scale was administered at 2 study visits: between 6 and 14 weeks’ gestation and between 22 and 30 weeks’ gestation. The Edinburgh Postpartum Depression Scale score trajectories were categorized as improved, stable, or worsened based on whether the scores changed by at least 1 standard deviation between the 2 visits. The frequencies of adverse pregnancy outcomes (hypertensive disorders of pregnancy, abruption, cesarean delivery, preterm birth [ie, <37 weeks’ gestation], small for gestational age neonates, neonatal intensive care unit admission, and maternal readmission) were compared with depression trajectories across gestation in bivariable and multivariable analyses. Secondary analyses evaluated the frequencies of spontaneous and medically indicated preterm births and frequencies of spontaneous and medically indicated preterm births before 35, 32, and 28 weeks’ gestation.
Of the 8784 women who completed the 2 antenatal Edinburgh Postpartum Depression Scale screens, 1141 (13.0%) had improved, 6663 (75.9%) had stable, and 980 (11.2%) had worsened depressive symptom trajectories across gestation. Compared with women with improved or stable depressive symptoms, those with worsened symptoms were more likely to experience preterm birth (8.3% vs 7.4% vs 9.9%, respectively; P=.018). After controlling for potential confounders, worsened depressive symptoms remained associated with more frequent preterm birth (adjusted odds ratio, 1.68; 95% confidence interval, 1.10–2.57).
Women with depression symptoms that worsen as pregnancy progresses have increased odds of preterm birth. Future research is warranted to optimize and implement effective prevention, screening, and treatment protocols for antenatal depressive symptoms as a strategy to prevent preterm birth.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2021.07.007</identifier><identifier>PMID: 34280383</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; adverse pregnancy outcomes ; antenatal depression ; Cohort Studies ; Depressive Disorder - psychology ; Female ; Humans ; mood disorder ; Parity ; perinatal depression ; Pregnancy ; Pregnancy Complications - psychology ; Pregnancy Outcome ; Prenatal Care ; preterm birth ; prevention of perinatal depression ; Prospective Studies ; Psychometrics ; trajectory ; United States ; Young Adult</subject><ispartof>American journal of obstetrics and gynecology, 2022-01, Vol.226 (1), p.108.e1-108.e9</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-6f96782e6bf7c1ffa3e840737c5e79518940c5902bd4cf9dde86d94b745257c93</citedby><cites>FETCH-LOGICAL-c455t-6f96782e6bf7c1ffa3e840737c5e79518940c5902bd4cf9dde86d94b745257c93</cites><orcidid>0000-0002-8379-0743</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002937821007936$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34280383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Emily S.</creatorcontrib><creatorcontrib>Saade, George R.</creatorcontrib><creatorcontrib>Simhan, Hyagriv N.</creatorcontrib><creatorcontrib>Monk, Catherine</creatorcontrib><creatorcontrib>Haas, David M.</creatorcontrib><creatorcontrib>Silver, Robert M.</creatorcontrib><creatorcontrib>Mercer, Brian M.</creatorcontrib><creatorcontrib>Parry, Samuel</creatorcontrib><creatorcontrib>Wing, Deborah A.</creatorcontrib><creatorcontrib>Reddy, Uma M.</creatorcontrib><creatorcontrib>Grobman, William A.</creatorcontrib><title>Trajectories of antenatal depression and adverse pregnancy outcomes</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Antenatal depression affects approximately 1 of 7 pregnancies, with an increasing prevalence across gestation. Data regarding the associations between antenatal depression and adverse pregnancy outcomes yielded conflicting results. However, previous studies evaluated the cross-sectional prevalence of depression at various time points and not the depressive symptom trajectory across gestation.
This study aimed to identify whether the trajectory of antenatal depressive symptoms is associated with different risks of adverse pregnancy outcomes.
This was a secondary analysis of a large multisite prospective cohort of nulliparous women across the United States. The Edinburgh Postpartum Depression Scale was administered at 2 study visits: between 6 and 14 weeks’ gestation and between 22 and 30 weeks’ gestation. The Edinburgh Postpartum Depression Scale score trajectories were categorized as improved, stable, or worsened based on whether the scores changed by at least 1 standard deviation between the 2 visits. The frequencies of adverse pregnancy outcomes (hypertensive disorders of pregnancy, abruption, cesarean delivery, preterm birth [ie, <37 weeks’ gestation], small for gestational age neonates, neonatal intensive care unit admission, and maternal readmission) were compared with depression trajectories across gestation in bivariable and multivariable analyses. Secondary analyses evaluated the frequencies of spontaneous and medically indicated preterm births and frequencies of spontaneous and medically indicated preterm births before 35, 32, and 28 weeks’ gestation.
Of the 8784 women who completed the 2 antenatal Edinburgh Postpartum Depression Scale screens, 1141 (13.0%) had improved, 6663 (75.9%) had stable, and 980 (11.2%) had worsened depressive symptom trajectories across gestation. Compared with women with improved or stable depressive symptoms, those with worsened symptoms were more likely to experience preterm birth (8.3% vs 7.4% vs 9.9%, respectively; P=.018). After controlling for potential confounders, worsened depressive symptoms remained associated with more frequent preterm birth (adjusted odds ratio, 1.68; 95% confidence interval, 1.10–2.57).
Women with depression symptoms that worsen as pregnancy progresses have increased odds of preterm birth. Future research is warranted to optimize and implement effective prevention, screening, and treatment protocols for antenatal depressive symptoms as a strategy to prevent preterm birth.</description><subject>Adult</subject><subject>adverse pregnancy outcomes</subject><subject>antenatal depression</subject><subject>Cohort Studies</subject><subject>Depressive Disorder - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>mood disorder</subject><subject>Parity</subject><subject>perinatal depression</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - psychology</subject><subject>Pregnancy Outcome</subject><subject>Prenatal Care</subject><subject>preterm birth</subject><subject>prevention of perinatal depression</subject><subject>Prospective Studies</subject><subject>Psychometrics</subject><subject>trajectory</subject><subject>United States</subject><subject>Young Adult</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7uzqH_AgffTSbSXpfIEIMugqLHhZzyGTVI9pepIx6RnYf283sy568VRU1VtvFU8R8oZCR4HK92PnxrzvGDDageoA1DOyoWBUK7XUz8kGAFhruNJX5LrWcU2ZYS_JFe-ZBq75hmzvixvRz7lErE0eGpdmTG52UxPwWLDWmNNSDI0LZywVm6W4Ty75hyafZp8PWF-RF4ObKr5-jDfkx5fP99uv7d3322_bT3et74WYWzkYqTRDuRuUp8PgOOoeFFdeoDKCatODFwbYLvR-MCGglsH0O9ULJpQ3_IZ8vPgeT7sDBo9pLm6yxxIPrjzY7KL9t5PiT7vPZ6tVr5lcDd49GpT864R1todYPU6TS5hP1TIhuGCcglyk7CL1JddacHhaQ8Gu9O1oV_p2pW9B2YX-MvT27wOfRv7gXgQfLgJcMJ0jFlt9xOQxxLI8wYYc_-f_G00bl6E</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Miller, Emily S.</creator><creator>Saade, George R.</creator><creator>Simhan, Hyagriv N.</creator><creator>Monk, Catherine</creator><creator>Haas, David M.</creator><creator>Silver, Robert M.</creator><creator>Mercer, Brian M.</creator><creator>Parry, Samuel</creator><creator>Wing, Deborah A.</creator><creator>Reddy, Uma M.</creator><creator>Grobman, William A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8379-0743</orcidid></search><sort><creationdate>20220101</creationdate><title>Trajectories of antenatal depression and adverse pregnancy outcomes</title><author>Miller, Emily S. ; Saade, George R. ; Simhan, Hyagriv N. ; Monk, Catherine ; Haas, David M. ; Silver, Robert M. ; Mercer, Brian M. ; Parry, Samuel ; Wing, Deborah A. ; Reddy, Uma M. ; Grobman, William A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-6f96782e6bf7c1ffa3e840737c5e79518940c5902bd4cf9dde86d94b745257c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>adverse pregnancy outcomes</topic><topic>antenatal depression</topic><topic>Cohort Studies</topic><topic>Depressive Disorder - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>mood disorder</topic><topic>Parity</topic><topic>perinatal depression</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - psychology</topic><topic>Pregnancy Outcome</topic><topic>Prenatal Care</topic><topic>preterm birth</topic><topic>prevention of perinatal depression</topic><topic>Prospective Studies</topic><topic>Psychometrics</topic><topic>trajectory</topic><topic>United States</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Emily S.</creatorcontrib><creatorcontrib>Saade, George R.</creatorcontrib><creatorcontrib>Simhan, Hyagriv N.</creatorcontrib><creatorcontrib>Monk, Catherine</creatorcontrib><creatorcontrib>Haas, David M.</creatorcontrib><creatorcontrib>Silver, Robert M.</creatorcontrib><creatorcontrib>Mercer, Brian M.</creatorcontrib><creatorcontrib>Parry, Samuel</creatorcontrib><creatorcontrib>Wing, Deborah A.</creatorcontrib><creatorcontrib>Reddy, Uma M.</creatorcontrib><creatorcontrib>Grobman, William A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, Emily S.</au><au>Saade, George R.</au><au>Simhan, Hyagriv N.</au><au>Monk, Catherine</au><au>Haas, David M.</au><au>Silver, Robert M.</au><au>Mercer, Brian M.</au><au>Parry, Samuel</au><au>Wing, Deborah A.</au><au>Reddy, Uma M.</au><au>Grobman, William A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trajectories of antenatal depression and adverse pregnancy outcomes</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>226</volume><issue>1</issue><spage>108.e1</spage><epage>108.e9</epage><pages>108.e1-108.e9</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>Antenatal depression affects approximately 1 of 7 pregnancies, with an increasing prevalence across gestation. Data regarding the associations between antenatal depression and adverse pregnancy outcomes yielded conflicting results. However, previous studies evaluated the cross-sectional prevalence of depression at various time points and not the depressive symptom trajectory across gestation.
This study aimed to identify whether the trajectory of antenatal depressive symptoms is associated with different risks of adverse pregnancy outcomes.
This was a secondary analysis of a large multisite prospective cohort of nulliparous women across the United States. The Edinburgh Postpartum Depression Scale was administered at 2 study visits: between 6 and 14 weeks’ gestation and between 22 and 30 weeks’ gestation. The Edinburgh Postpartum Depression Scale score trajectories were categorized as improved, stable, or worsened based on whether the scores changed by at least 1 standard deviation between the 2 visits. The frequencies of adverse pregnancy outcomes (hypertensive disorders of pregnancy, abruption, cesarean delivery, preterm birth [ie, <37 weeks’ gestation], small for gestational age neonates, neonatal intensive care unit admission, and maternal readmission) were compared with depression trajectories across gestation in bivariable and multivariable analyses. Secondary analyses evaluated the frequencies of spontaneous and medically indicated preterm births and frequencies of spontaneous and medically indicated preterm births before 35, 32, and 28 weeks’ gestation.
Of the 8784 women who completed the 2 antenatal Edinburgh Postpartum Depression Scale screens, 1141 (13.0%) had improved, 6663 (75.9%) had stable, and 980 (11.2%) had worsened depressive symptom trajectories across gestation. Compared with women with improved or stable depressive symptoms, those with worsened symptoms were more likely to experience preterm birth (8.3% vs 7.4% vs 9.9%, respectively; P=.018). After controlling for potential confounders, worsened depressive symptoms remained associated with more frequent preterm birth (adjusted odds ratio, 1.68; 95% confidence interval, 1.10–2.57).
Women with depression symptoms that worsen as pregnancy progresses have increased odds of preterm birth. Future research is warranted to optimize and implement effective prevention, screening, and treatment protocols for antenatal depressive symptoms as a strategy to prevent preterm birth.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34280383</pmid><doi>10.1016/j.ajog.2021.07.007</doi><orcidid>https://orcid.org/0000-0002-8379-0743</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 2022-01, Vol.226 (1), p.108.e1-108.e9 |
| issn | 0002-9378 1097-6868 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8748269 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult adverse pregnancy outcomes antenatal depression Cohort Studies Depressive Disorder - psychology Female Humans mood disorder Parity perinatal depression Pregnancy Pregnancy Complications - psychology Pregnancy Outcome Prenatal Care preterm birth prevention of perinatal depression Prospective Studies Psychometrics trajectory United States Young Adult |
| title | Trajectories of antenatal depression and adverse pregnancy outcomes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T14%3A19%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Trajectories%20of%20antenatal%20depression%20and%20adverse%20pregnancy%20outcomes&rft.jtitle=American%20journal%20of%20obstetrics%20and%20gynecology&rft.au=Miller,%20Emily%20S.&rft.date=2022-01-01&rft.volume=226&rft.issue=1&rft.spage=108.e1&rft.epage=108.e9&rft.pages=108.e1-108.e9&rft.issn=0002-9378&rft.eissn=1097-6868&rft_id=info:doi/10.1016/j.ajog.2021.07.007&rft_dat=%3Cproquest_pubme%3E2553523106%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2553523106&rft_id=info:pmid/34280383&rft_els_id=S0002937821007936&rfr_iscdi=true |