Clinical characteristics and prediction analysis of the recovered COVID-19 patients with re-detectable positive RNA test
Previous studies have unveiled the occurrence of re-detectable positive (RP) RNA test result after hospital discharge among recovered COVID-19 patients, but the clinical characteristics of RP patients (RP patients) and the potential features affecting RP RNA test outcome remain unclear. A total of 7...
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| Veröffentlicht in: | American journal of translational research 2021-01, Vol.13 (12), p.14157-14167 |
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| creator | Li, Qi Shuai, Li Tan, Li Song, Lijun Ou, Chongyang Song, Xiaocheng He, Jian Gao, Ming Hu, Xinyu Liu, Yang Chen, Hui Zou, Zui Yu, Chao Qin, Baodong Xu, Wenyun |
| description | Previous studies have unveiled the occurrence of re-detectable positive (RP) RNA test result after hospital discharge among recovered COVID-19 patients, but the clinical characteristics of RP patients (RP patients) and the potential features affecting RP RNA test outcome remain unclear.
A total of 742 COVID-19 patients discharged between March 1
, 2020 and March 20
, 2020 were enrolled. All patients were followed-up for SARS-CoV-2 RNA test and RP patents were identified. The clinical characteristics between RP patients and NRP patients were compared, and the potential features affecting re-detectable RNA test outcome were further evaluated.
Up to April 9
, 2020, 60 recovered patients (8.09%) had been re-detected to be SARS-CoV-2 RNA positive. Among those 60 RP patients, the median RP time was 12 days from the last negative result of SARS-CoV-2 RNA test or 10 days from hospital discharge. RP patients were prone to be older, having mild/moderate conditions, unilateral lung involvement and fatigue, chills, stuffy or runny nose, with high lymphocyte count. Multivariate logistic analysis and COX regression analysis demonstrated that age, lymphocyte count, urea nitrogen, stuffy or runny nose as well as lung involvement were independently associated with RP RNA test ( |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8748099</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2620754296</sourcerecordid><originalsourceid>FETCH-LOGICAL-p196t-201d7c6ca87ae04041d281be5f9aa29d12a82a14d339c299d3ade8cc743a343d3</originalsourceid><addsrcrecordid>eNpVkFtLAzEQhRdRbK3-BcmjLwuby17yIpT1VigWRH1dpsnUjaSbNUmr_fcuWKU-zQzn8J3DHCVjKgVPKyro8cE-Ss5CeM-yIpcFO01GPM94XhZ0nHzV1nRGgSWqBQ8qojchGhUIdJr0HrVR0bhuOMHuggnErUhskXhUbouDTurF6-wmpZL0EA12MZBPE9vBkGqMqCIsLZLeBRPNFsnT45REDPE8OVmBDXixn5Pk5e72uX5I54v7WT2dpz2VRUxZRnWpCgVVCZiJTFDNKrrEfCUBmNSUQcWACs25VExKzUFjpVQpOHDBNZ8k1z_cfrNco1ZDQQ-26b1Zg981DkzzX-lM27y5bVOVosqkHABXe4B3H5uhebM2QaG10KHbhIYVLCtzwWQxWC8Ps_5Cft_NvwFjXH9_</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2620754296</pqid></control><display><type>article</type><title>Clinical characteristics and prediction analysis of the recovered COVID-19 patients with re-detectable positive RNA test</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Li, Qi ; Shuai, Li ; Tan, Li ; Song, Lijun ; Ou, Chongyang ; Song, Xiaocheng ; He, Jian ; Gao, Ming ; Hu, Xinyu ; Liu, Yang ; Chen, Hui ; Zou, Zui ; Yu, Chao ; Qin, Baodong ; Xu, Wenyun</creator><creatorcontrib>Li, Qi ; Shuai, Li ; Tan, Li ; Song, Lijun ; Ou, Chongyang ; Song, Xiaocheng ; He, Jian ; Gao, Ming ; Hu, Xinyu ; Liu, Yang ; Chen, Hui ; Zou, Zui ; Yu, Chao ; Qin, Baodong ; Xu, Wenyun</creatorcontrib><description>Previous studies have unveiled the occurrence of re-detectable positive (RP) RNA test result after hospital discharge among recovered COVID-19 patients, but the clinical characteristics of RP patients (RP patients) and the potential features affecting RP RNA test outcome remain unclear.
A total of 742 COVID-19 patients discharged between March 1
, 2020 and March 20
, 2020 were enrolled. All patients were followed-up for SARS-CoV-2 RNA test and RP patents were identified. The clinical characteristics between RP patients and NRP patients were compared, and the potential features affecting re-detectable RNA test outcome were further evaluated.
Up to April 9
, 2020, 60 recovered patients (8.09%) had been re-detected to be SARS-CoV-2 RNA positive. Among those 60 RP patients, the median RP time was 12 days from the last negative result of SARS-CoV-2 RNA test or 10 days from hospital discharge. RP patients were prone to be older, having mild/moderate conditions, unilateral lung involvement and fatigue, chills, stuffy or runny nose, with high lymphocyte count. Multivariate logistic analysis and COX regression analysis demonstrated that age, lymphocyte count, urea nitrogen, stuffy or runny nose as well as lung involvement were independently associated with RP RNA test (
<0.05).
Older patients accompanied with stuffy or runny nose, low urea nitrogen as well as unilateral lung involvement were more likely to develop RP RNA test result after hospital discharge. Therefore, we strongly suggest using broncho-alveolar lavage fluid for RNA detection, extending quarantine time, and conducting continual follow-up medical examination for those discharged patients.</description><identifier>ISSN: 1943-8141</identifier><identifier>EISSN: 1943-8141</identifier><identifier>PMID: 35035761</identifier><language>eng</language><publisher>United States: e-Century Publishing Corporation</publisher><subject>Original</subject><ispartof>American journal of translational research, 2021-01, Vol.13 (12), p.14157-14167</ispartof><rights>AJTR Copyright © 2021.</rights><rights>AJTR Copyright © 2021 2021</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748099/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748099/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35035761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Shuai, Li</creatorcontrib><creatorcontrib>Tan, Li</creatorcontrib><creatorcontrib>Song, Lijun</creatorcontrib><creatorcontrib>Ou, Chongyang</creatorcontrib><creatorcontrib>Song, Xiaocheng</creatorcontrib><creatorcontrib>He, Jian</creatorcontrib><creatorcontrib>Gao, Ming</creatorcontrib><creatorcontrib>Hu, Xinyu</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Zou, Zui</creatorcontrib><creatorcontrib>Yu, Chao</creatorcontrib><creatorcontrib>Qin, Baodong</creatorcontrib><creatorcontrib>Xu, Wenyun</creatorcontrib><title>Clinical characteristics and prediction analysis of the recovered COVID-19 patients with re-detectable positive RNA test</title><title>American journal of translational research</title><addtitle>Am J Transl Res</addtitle><description>Previous studies have unveiled the occurrence of re-detectable positive (RP) RNA test result after hospital discharge among recovered COVID-19 patients, but the clinical characteristics of RP patients (RP patients) and the potential features affecting RP RNA test outcome remain unclear.
A total of 742 COVID-19 patients discharged between March 1
, 2020 and March 20
, 2020 were enrolled. All patients were followed-up for SARS-CoV-2 RNA test and RP patents were identified. The clinical characteristics between RP patients and NRP patients were compared, and the potential features affecting re-detectable RNA test outcome were further evaluated.
Up to April 9
, 2020, 60 recovered patients (8.09%) had been re-detected to be SARS-CoV-2 RNA positive. Among those 60 RP patients, the median RP time was 12 days from the last negative result of SARS-CoV-2 RNA test or 10 days from hospital discharge. RP patients were prone to be older, having mild/moderate conditions, unilateral lung involvement and fatigue, chills, stuffy or runny nose, with high lymphocyte count. Multivariate logistic analysis and COX regression analysis demonstrated that age, lymphocyte count, urea nitrogen, stuffy or runny nose as well as lung involvement were independently associated with RP RNA test (
<0.05).
Older patients accompanied with stuffy or runny nose, low urea nitrogen as well as unilateral lung involvement were more likely to develop RP RNA test result after hospital discharge. Therefore, we strongly suggest using broncho-alveolar lavage fluid for RNA detection, extending quarantine time, and conducting continual follow-up medical examination for those discharged patients.</description><subject>Original</subject><issn>1943-8141</issn><issn>1943-8141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkFtLAzEQhRdRbK3-BcmjLwuby17yIpT1VigWRH1dpsnUjaSbNUmr_fcuWKU-zQzn8J3DHCVjKgVPKyro8cE-Ss5CeM-yIpcFO01GPM94XhZ0nHzV1nRGgSWqBQ8qojchGhUIdJr0HrVR0bhuOMHuggnErUhskXhUbouDTurF6-wmpZL0EA12MZBPE9vBkGqMqCIsLZLeBRPNFsnT45REDPE8OVmBDXixn5Pk5e72uX5I54v7WT2dpz2VRUxZRnWpCgVVCZiJTFDNKrrEfCUBmNSUQcWACs25VExKzUFjpVQpOHDBNZ8k1z_cfrNco1ZDQQ-26b1Zg981DkzzX-lM27y5bVOVosqkHABXe4B3H5uhebM2QaG10KHbhIYVLCtzwWQxWC8Ps_5Cft_NvwFjXH9_</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Li, Qi</creator><creator>Shuai, Li</creator><creator>Tan, Li</creator><creator>Song, Lijun</creator><creator>Ou, Chongyang</creator><creator>Song, Xiaocheng</creator><creator>He, Jian</creator><creator>Gao, Ming</creator><creator>Hu, Xinyu</creator><creator>Liu, Yang</creator><creator>Chen, Hui</creator><creator>Zou, Zui</creator><creator>Yu, Chao</creator><creator>Qin, Baodong</creator><creator>Xu, Wenyun</creator><general>e-Century Publishing Corporation</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210101</creationdate><title>Clinical characteristics and prediction analysis of the recovered COVID-19 patients with re-detectable positive RNA test</title><author>Li, Qi ; Shuai, Li ; Tan, Li ; Song, Lijun ; Ou, Chongyang ; Song, Xiaocheng ; He, Jian ; Gao, Ming ; Hu, Xinyu ; Liu, Yang ; Chen, Hui ; Zou, Zui ; Yu, Chao ; Qin, Baodong ; Xu, Wenyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p196t-201d7c6ca87ae04041d281be5f9aa29d12a82a14d339c299d3ade8cc743a343d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Qi</creatorcontrib><creatorcontrib>Shuai, Li</creatorcontrib><creatorcontrib>Tan, Li</creatorcontrib><creatorcontrib>Song, Lijun</creatorcontrib><creatorcontrib>Ou, Chongyang</creatorcontrib><creatorcontrib>Song, Xiaocheng</creatorcontrib><creatorcontrib>He, Jian</creatorcontrib><creatorcontrib>Gao, Ming</creatorcontrib><creatorcontrib>Hu, Xinyu</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Zou, Zui</creatorcontrib><creatorcontrib>Yu, Chao</creatorcontrib><creatorcontrib>Qin, Baodong</creatorcontrib><creatorcontrib>Xu, Wenyun</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of translational research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Qi</au><au>Shuai, Li</au><au>Tan, Li</au><au>Song, Lijun</au><au>Ou, Chongyang</au><au>Song, Xiaocheng</au><au>He, Jian</au><au>Gao, Ming</au><au>Hu, Xinyu</au><au>Liu, Yang</au><au>Chen, Hui</au><au>Zou, Zui</au><au>Yu, Chao</au><au>Qin, Baodong</au><au>Xu, Wenyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics and prediction analysis of the recovered COVID-19 patients with re-detectable positive RNA test</atitle><jtitle>American journal of translational research</jtitle><addtitle>Am J Transl Res</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>13</volume><issue>12</issue><spage>14157</spage><epage>14167</epage><pages>14157-14167</pages><issn>1943-8141</issn><eissn>1943-8141</eissn><abstract>Previous studies have unveiled the occurrence of re-detectable positive (RP) RNA test result after hospital discharge among recovered COVID-19 patients, but the clinical characteristics of RP patients (RP patients) and the potential features affecting RP RNA test outcome remain unclear.
A total of 742 COVID-19 patients discharged between March 1
, 2020 and March 20
, 2020 were enrolled. All patients were followed-up for SARS-CoV-2 RNA test and RP patents were identified. The clinical characteristics between RP patients and NRP patients were compared, and the potential features affecting re-detectable RNA test outcome were further evaluated.
Up to April 9
, 2020, 60 recovered patients (8.09%) had been re-detected to be SARS-CoV-2 RNA positive. Among those 60 RP patients, the median RP time was 12 days from the last negative result of SARS-CoV-2 RNA test or 10 days from hospital discharge. RP patients were prone to be older, having mild/moderate conditions, unilateral lung involvement and fatigue, chills, stuffy or runny nose, with high lymphocyte count. Multivariate logistic analysis and COX regression analysis demonstrated that age, lymphocyte count, urea nitrogen, stuffy or runny nose as well as lung involvement were independently associated with RP RNA test (
<0.05).
Older patients accompanied with stuffy or runny nose, low urea nitrogen as well as unilateral lung involvement were more likely to develop RP RNA test result after hospital discharge. Therefore, we strongly suggest using broncho-alveolar lavage fluid for RNA detection, extending quarantine time, and conducting continual follow-up medical examination for those discharged patients.</abstract><cop>United States</cop><pub>e-Century Publishing Corporation</pub><pmid>35035761</pmid><tpages>11</tpages></addata></record> |
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| title | Clinical characteristics and prediction analysis of the recovered COVID-19 patients with re-detectable positive RNA test |
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