Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis
Whether the gut microbiome in obesity is characterized by lower diversity and altered composition at the phylum or genus level may be more accurately investigated using high-throughput sequencing technologies. We conducted a systematic review in PubMed and Embase including 32 cross-sectional studies...
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| Veröffentlicht in: | Nutrients 2021-12, Vol.14 (1), p.12 |
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| creator | Pinart, Mariona Dötsch, Andreas Schlicht, Kristina Laudes, Matthias Bouwman, Jildau Forslund, Sofia K Pischon, Tobias Nimptsch, Katharina |
| description | Whether the gut microbiome in obesity is characterized by lower diversity and altered composition at the phylum or genus level may be more accurately investigated using high-throughput sequencing technologies. We conducted a systematic review in PubMed and Embase including 32 cross-sectional studies assessing the gut microbiome composition by high-throughput sequencing in obese and non-obese adults. A significantly lower alpha diversity (Shannon index) in obese versus non-obese adults was observed in nine out of 22 studies, and meta-analysis of seven studies revealed a non-significant mean difference (-0.06, 95% CI -0.24, 0.12,
= 81%). At the phylum level, significantly more Firmicutes and fewer Bacteroidetes in obese versus non-obese adults were observed in six out of seventeen, and in four out of eighteen studies, respectively. Meta-analyses of six studies revealed significantly higher Firmicutes (5.50, 95% 0.27, 10.73,
= 81%) and non-significantly lower Bacteroidetes (-4.79, 95% CI -10.77, 1.20,
= 86%). At the genus level, lower relative proportions of
and
and higher
,
,
,
,
,
,
,
,
,
,
,
, and
were found in obese versus non-obese adults. Although a proportion of studies found lower diversity and differences in gut microbiome composition in obese versus non-obese adults, the observed heterogeneity across studies precludes clear answers. |
| doi_str_mv | 10.3390/nu14010012 |
| format | Article |
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= 81%). At the phylum level, significantly more Firmicutes and fewer Bacteroidetes in obese versus non-obese adults were observed in six out of seventeen, and in four out of eighteen studies, respectively. Meta-analyses of six studies revealed significantly higher Firmicutes (5.50, 95% 0.27, 10.73,
= 81%) and non-significantly lower Bacteroidetes (-4.79, 95% CI -10.77, 1.20,
= 86%). At the genus level, lower relative proportions of
and
and higher
,
,
,
,
,
,
,
,
,
,
,
, and
were found in obese versus non-obese adults. Although a proportion of studies found lower diversity and differences in gut microbiome composition in obese versus non-obese adults, the observed heterogeneity across studies precludes clear answers.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu14010012</identifier><identifier>PMID: 35010887</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adults ; Bacteria - classification ; Bacteria - genetics ; Bacteroidetes ; Body mass index ; Composition ; Cross-sectional studies ; Digestive system ; Feces - microbiology ; Firmicutes ; Gastrointestinal Microbiome ; Gastrointestinal surgery ; Heterogeneity ; High-Throughput Nucleotide Sequencing ; Humans ; Intestinal microflora ; Measurement techniques ; Meta-analysis ; Microbiomes ; Microbiota ; Next-generation sequencing ; Obesity ; Obesity - microbiology ; Overweight ; Population ; Review ; Systematic review ; Taxonomy ; Womens health</subject><ispartof>Nutrients, 2021-12, Vol.14 (1), p.12</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-9d8386fc86187ab5b6585acd628e6eaa9a23904035c46db3310a00945eb7b60b3</citedby><cites>FETCH-LOGICAL-c472t-9d8386fc86187ab5b6585acd628e6eaa9a23904035c46db3310a00945eb7b60b3</cites><orcidid>0000-0001-9086-2584 ; 0000-0002-8223-1325 ; 0000-0003-4285-6993 ; 0000-0003-1568-767X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746372/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746372/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35010887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinart, Mariona</creatorcontrib><creatorcontrib>Dötsch, Andreas</creatorcontrib><creatorcontrib>Schlicht, Kristina</creatorcontrib><creatorcontrib>Laudes, Matthias</creatorcontrib><creatorcontrib>Bouwman, Jildau</creatorcontrib><creatorcontrib>Forslund, Sofia K</creatorcontrib><creatorcontrib>Pischon, Tobias</creatorcontrib><creatorcontrib>Nimptsch, Katharina</creatorcontrib><title>Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Whether the gut microbiome in obesity is characterized by lower diversity and altered composition at the phylum or genus level may be more accurately investigated using high-throughput sequencing technologies. We conducted a systematic review in PubMed and Embase including 32 cross-sectional studies assessing the gut microbiome composition by high-throughput sequencing in obese and non-obese adults. A significantly lower alpha diversity (Shannon index) in obese versus non-obese adults was observed in nine out of 22 studies, and meta-analysis of seven studies revealed a non-significant mean difference (-0.06, 95% CI -0.24, 0.12,
= 81%). At the phylum level, significantly more Firmicutes and fewer Bacteroidetes in obese versus non-obese adults were observed in six out of seventeen, and in four out of eighteen studies, respectively. Meta-analyses of six studies revealed significantly higher Firmicutes (5.50, 95% 0.27, 10.73,
= 81%) and non-significantly lower Bacteroidetes (-4.79, 95% CI -10.77, 1.20,
= 86%). At the genus level, lower relative proportions of
and
and higher
,
,
,
,
,
,
,
,
,
,
,
, and
were found in obese versus non-obese adults. 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We conducted a systematic review in PubMed and Embase including 32 cross-sectional studies assessing the gut microbiome composition by high-throughput sequencing in obese and non-obese adults. A significantly lower alpha diversity (Shannon index) in obese versus non-obese adults was observed in nine out of 22 studies, and meta-analysis of seven studies revealed a non-significant mean difference (-0.06, 95% CI -0.24, 0.12,
= 81%). At the phylum level, significantly more Firmicutes and fewer Bacteroidetes in obese versus non-obese adults were observed in six out of seventeen, and in four out of eighteen studies, respectively. Meta-analyses of six studies revealed significantly higher Firmicutes (5.50, 95% 0.27, 10.73,
= 81%) and non-significantly lower Bacteroidetes (-4.79, 95% CI -10.77, 1.20,
= 86%). At the genus level, lower relative proportions of
and
and higher
,
,
,
,
,
,
,
,
,
,
,
, and
were found in obese versus non-obese adults. Although a proportion of studies found lower diversity and differences in gut microbiome composition in obese versus non-obese adults, the observed heterogeneity across studies precludes clear answers.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35010887</pmid><doi>10.3390/nu14010012</doi><orcidid>https://orcid.org/0000-0001-9086-2584</orcidid><orcidid>https://orcid.org/0000-0002-8223-1325</orcidid><orcidid>https://orcid.org/0000-0003-4285-6993</orcidid><orcidid>https://orcid.org/0000-0003-1568-767X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adults Bacteria - classification Bacteria - genetics Bacteroidetes Body mass index Composition Cross-sectional studies Digestive system Feces - microbiology Firmicutes Gastrointestinal Microbiome Gastrointestinal surgery Heterogeneity High-Throughput Nucleotide Sequencing Humans Intestinal microflora Measurement techniques Meta-analysis Microbiomes Microbiota Next-generation sequencing Obesity Obesity - microbiology Overweight Population Review Systematic review Taxonomy Womens health |
| title | Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis |
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