Histone Modifications and Their Targeting in Lymphoid Malignancies

In a wide range of lymphoid neoplasms, the process of malignant transformation is associated with somatic mutations in B cells that affect the epigenetic machinery. Consequential alterations in histone modifications contribute to disease-specific changes in the transcriptional program. Affected gene...

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Veröffentlicht in:	International journal of molecular sciences 2021-12, Vol.23 (1), p.253
Hauptverfasser:	Fernández-Serrano, Miranda, Winkler, René, Santos, Juliana C, Le Pannérer, Marguerite-Marie, Buschbeck, Marcus, Roué, Gaël
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Apoptosis B-cell lymphoma Cell cycle Chemotherapy Clinical Trials as Topic DNA damage DNA methylation Drug development Enzymes Epigenesis, Genetic Epigenetics Gene expression Histones Histones - metabolism Humans Immune system Immunosuppressive agents Immunosurveillance Lymphatic system Lymphocytes B Lymphoma Lymphoma - genetics Lymphoma - metabolism Medical prognosis Models, Biological Mutation Neoplasms Protein Processing, Post-Translational Proteins Radiation therapy Review Signal transduction Transcription Tumors
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