Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer

ObjectiveEnhancer aberrations are beginning to emerge as a key epigenetic feature of colorectal cancers (CRC), however, a comprehensive knowledge of chromatin state patterns in tumour progression, heterogeneity of these patterns and imparted therapeutic opportunities remain poorly described.DesignWe...

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Veröffentlicht in:	Gut 2022-05, Vol.71 (5), p.938-949
Hauptverfasser:	Orouji, Elias, Raman, Ayush T, Singh, Anand K, Sorokin, Alexey, Arslan, Emre, Ghosh, Archit K, Schulz, Jonathan, Terranova, Christopher, Jiang, Shan, Tang, Ming, Maitituoheti, Mayinuer, Callahan, Scot C, Barrodia, Praveen, Tomczak, Katarzyna, Jiang, Yingda, Jiang, Zhiqin, Davis, Jennifer S, Ghosh, Sukhen, Lee, Hey Min, Reyes-Uribe, Laura, Chang, Kyle, Liu, Yusha, Chen, Huiqin, Azhdarinia, Ali, Morris, Jeffrey, Vilar, Eduardo, Carmon, Kendra S, Kopetz, Scott E, Rai, Kunal
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma Basic Helix-Loop-Helix Transcription Factors cancer genetics Chromatin Colon Colon cancer colon carcinogenesis Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics DNA methylation Enhancer Elements, Genetic - genetics Enhancers Epigenetics Gene expression Gene loci Genomics Heterochromatin Histones Humans Nuclear Proteins Polycomb group proteins Promoters Transcription Transcription Factors - genetics Transcriptomics Tumor cell lines Tumors Xenografts
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