The Micro-Immunotherapy Medicine 2LEID Exhibits an Immunostimulant Effect by Boosting Both Innate and Adaptive Immune Responses

This study aimed at evaluating the effects of the micro-immunotherapy medicine (MIM) 2LEID, both in vitro and in vivo, on several components of the innate and adaptive immune system. MIM increased the phagocytic activity of macrophages, and it augmented the expression of the activation markers CD69...

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Veröffentlicht in:	International journal of molecular sciences 2021-12, Vol.23 (1), p.110
Hauptverfasser:	Jacques, Camille, Chatelais, Mathias, Fekir, Karim, Fauconnier, Louis, Mellier, Manon, Togbe, Dieudonnée, Floris, Ilaria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adaptive Immunity - drug effects Adaptive Immunity - immunology Adaptive systems Adjuvants, Immunologic - pharmacology Animals Antigens Biomarkers - metabolism CD14 antigen CD3 antigen CD69 antigen Cell Proliferation - physiology Cells, Cultured Cytokines Cytokines - immunology Dendritic cells Disease prevention Endothelial cells Endothelial Cells - drug effects Endothelial Cells - immunology Female Growth factors Histocompatibility antigen HLA Humans Immune response Immune system Immunity, Innate - drug effects Immunity, Innate - immunology Immunoglobulin M Immunostimulants Immunotherapy Immunotherapy - methods Infections Infectious diseases Influenza Influenza A Intercellular adhesion molecule 1 Interleukin 10 Interleukin-10 - immunology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lactose Leukocytes (neutrophilic) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Lung - drug effects Lung - immunology Lymphocytes Lymphocytes T Macrophages Macrophages - drug effects Macrophages - immunology Markers Mice Mice, Inbred BALB C Monocytes Monocytes - drug effects Monocytes - immunology Neutrophils - drug effects Neutrophils - immunology Pathogens PD-L1 protein Phagocytes T-Lymphocytes - drug effects T-Lymphocytes - immunology Tumor necrosis factor-TNF Umbilical vein
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