IL-25 Induced ROS-Mediated M2 Macrophage Polarization via AMPK-Associated Mitophagy

Interleukin (IL)-25 is a cytokine released by airway epithelial cells responding to pathogens. Excessive production of reactive oxygen species (ROS) leads to airway inflammation and remodeling in asthma. Mitochondria are the major source of ROS. After stress, defective mitochondria often undergo sel...

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Veröffentlicht in:	International journal of molecular sciences 2021-12, Vol.23 (1), p.3
Hauptverfasser:	Tsai, Mei-Lan, Tsai, Yi-Giien, Lin, Yu-Chih, Hsu, Ya-Ling, Chen, Yi-Ting, Tsai, Ming-Kai, Liao, Wei-Ting, Lin, Yi-Ching, Hung, Chih-Hsing
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Acetylcysteine - pharmacology AMP-Activated Protein Kinases - metabolism Antimycin A - pharmacology Ascorbic acid Ascorbic Acid - pharmacology Asthma Autophagy Cell Polarity Chronic illnesses Confocal microscopy Cytokines Electron transport chain Enzyme-linked immunosorbent assay Epithelial cells Epithelium Flow Cytometry Humans Interleukin-17 - metabolism Interleukin-17 - pharmacology Kinases Lymphocytes T Macrophages Macrophages - cytology Macrophages - metabolism Microscopy, Confocal Mitochondria Mitochondria - metabolism Mitophagy Monocytes Monocytes - cytology Monocytes - metabolism NADH-ubiquinone oxidoreductase Organophosphorus Compounds - pharmacology Oxidative stress Phosphorylation - drug effects Piperidines - pharmacology Polarization Proteins PTEN-induced putative kinase Pulmonary fibrosis Reactive oxygen species Reactive Oxygen Species - metabolism Respiratory tract Respiratory tract diseases Stimulation THP-1 Cells Western blotting
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