Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels
Calciotropic hormones, parathyroid hormone (PTH) and calcitonin are involved in the regulation of bone mineral metabolism and maintenance of calcium and phosphate homeostasis in the body. Therefore, an understanding of environmental and genetic factors influencing PTH and calcitonin levels is crucia...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2021-12, Vol.23 (1), p.44 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 44 |
| container_title | International journal of molecular sciences |
| container_volume | 23 |
| creator | Babić Leko, Mirjana Pleić, Nikolina Gunjača, Ivana Zemunik, Tatijana |
| description | Calciotropic hormones, parathyroid hormone (PTH) and calcitonin are involved in the regulation of bone mineral metabolism and maintenance of calcium and phosphate homeostasis in the body. Therefore, an understanding of environmental and genetic factors influencing PTH and calcitonin levels is crucial. Genetic factors are estimated to account for 60% of variations in PTH levels, while the genetic background of interindividual calcitonin variations has not yet been studied. In this review, we analyzed the literature discussing the influence of environmental factors (lifestyle factors and pollutants) on PTH and calcitonin levels. Among lifestyle factors, smoking, body mass index (BMI), diet, alcohol, and exercise were analyzed; among pollutants, heavy metals and chemicals were analyzed. Lifestyle factors that showed the clearest association with PTH levels were smoking, BMI, exercise, and micronutrients taken from the diet (vitamin D and calcium). Smoking, vitamin D, and calcium intake led to a decrease in PTH levels, while higher BMI and exercise led to an increase in PTH levels. In terms of pollutants, exposure to cadmium led to a decrease in PTH levels, while exposure to lead increased PTH levels. Several studies have investigated the effect of chemicals on PTH levels in humans. Compared to PTH studies, a smaller number of studies analyzed the influence of environmental factors on calcitonin levels, which gives great variability in results. Only a few studies have analyzed the influence of pollutants on calcitonin levels in humans. The lifestyle factor with the clearest relationship with calcitonin was smoking (smokers had increased calcitonin levels). Given the importance of PTH and calcitonin in maintaining calcium and phosphate homeostasis and bone mineral metabolism, additional studies on the influence of environmental factors that could affect PTH and calcitonin levels are crucial. |
| doi_str_mv | 10.3390/ijms23010044 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8744774</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2618238845</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-eaa058aff2b77aee395f204a556518d6bcb8b6d3113374e921ef60f770f3a7ee3</originalsourceid><addsrcrecordid>eNpdkc1LxDAQxYMoft88S8GLB1cnH23SiyDL-oELetBzmLaJm6VNNOku-N9bdZVV5jAD8-PxHo-QIwrnnJdw4eZdYhwogBAbZJcKxkYAhdxcu3fIXkpzAMZZXm6THZ4DKFGoXXI_8UsXg--M77HNrrHuQ0zZ0wz77MpaU_fZI0bsZ-8xuCa7DbEL3mTom2yMbe364J3PpmZp2nRAtiy2yRyu9j55vp48jW9H04ebu_HVdFQLyvqRQYRcobWskhKN4WVuGQjM8yKnqimqulJV0XBKOZfClIwaW4CVEixHOfD75PJb93VRdaapB-sRW_0aXYfxXQd0-u_Hu5l-CUutpBBSikHgdCUQw9vCpF53LtWmbdGbsEiaFVSVMEw5oCf_0HlYRD_E-6IYV0rkA3X2TdUxpBSN_TVDQX-2pNdbGvDj9QC_8E8t_AN6x45s</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2618238845</pqid></control><display><type>article</type><title>Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Babić Leko, Mirjana ; Pleić, Nikolina ; Gunjača, Ivana ; Zemunik, Tatijana</creator><creatorcontrib>Babić Leko, Mirjana ; Pleić, Nikolina ; Gunjača, Ivana ; Zemunik, Tatijana</creatorcontrib><description>Calciotropic hormones, parathyroid hormone (PTH) and calcitonin are involved in the regulation of bone mineral metabolism and maintenance of calcium and phosphate homeostasis in the body. Therefore, an understanding of environmental and genetic factors influencing PTH and calcitonin levels is crucial. Genetic factors are estimated to account for 60% of variations in PTH levels, while the genetic background of interindividual calcitonin variations has not yet been studied. In this review, we analyzed the literature discussing the influence of environmental factors (lifestyle factors and pollutants) on PTH and calcitonin levels. Among lifestyle factors, smoking, body mass index (BMI), diet, alcohol, and exercise were analyzed; among pollutants, heavy metals and chemicals were analyzed. Lifestyle factors that showed the clearest association with PTH levels were smoking, BMI, exercise, and micronutrients taken from the diet (vitamin D and calcium). Smoking, vitamin D, and calcium intake led to a decrease in PTH levels, while higher BMI and exercise led to an increase in PTH levels. In terms of pollutants, exposure to cadmium led to a decrease in PTH levels, while exposure to lead increased PTH levels. Several studies have investigated the effect of chemicals on PTH levels in humans. Compared to PTH studies, a smaller number of studies analyzed the influence of environmental factors on calcitonin levels, which gives great variability in results. Only a few studies have analyzed the influence of pollutants on calcitonin levels in humans. The lifestyle factor with the clearest relationship with calcitonin was smoking (smokers had increased calcitonin levels). Given the importance of PTH and calcitonin in maintaining calcium and phosphate homeostasis and bone mineral metabolism, additional studies on the influence of environmental factors that could affect PTH and calcitonin levels are crucial.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms23010044</identifier><identifier>PMID: 35008468</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Body mass index ; Body size ; Cadmium ; Calciferol ; Calcitonin ; Calcitonin - metabolism ; Calcium ; Calcium - metabolism ; Calcium homeostasis ; Calcium phosphates ; Dairy products ; Diet ; Enzymes ; Food ; Genetic factors ; Heavy metals ; Homeostasis ; Homeostasis - physiology ; Humans ; Life Style ; Literature reviews ; Micronutrients ; Mineral metabolism ; Parathyroid ; Parathyroid hormone ; Parathyroid Hormone - metabolism ; Phosphates - metabolism ; Phosphorus ; Physiology ; Pollutants ; Proteins ; Review ; Smoking ; Thyroid gland ; Vitamin D</subject><ispartof>International journal of molecular sciences, 2021-12, Vol.23 (1), p.44</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-eaa058aff2b77aee395f204a556518d6bcb8b6d3113374e921ef60f770f3a7ee3</citedby><cites>FETCH-LOGICAL-c412t-eaa058aff2b77aee395f204a556518d6bcb8b6d3113374e921ef60f770f3a7ee3</cites><orcidid>0000-0002-7056-6443 ; 0000-0001-5672-871X ; 0000-0003-4223-4190 ; 0000-0001-8120-2891</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744774/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744774/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35008468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Babić Leko, Mirjana</creatorcontrib><creatorcontrib>Pleić, Nikolina</creatorcontrib><creatorcontrib>Gunjača, Ivana</creatorcontrib><creatorcontrib>Zemunik, Tatijana</creatorcontrib><title>Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Calciotropic hormones, parathyroid hormone (PTH) and calcitonin are involved in the regulation of bone mineral metabolism and maintenance of calcium and phosphate homeostasis in the body. Therefore, an understanding of environmental and genetic factors influencing PTH and calcitonin levels is crucial. Genetic factors are estimated to account for 60% of variations in PTH levels, while the genetic background of interindividual calcitonin variations has not yet been studied. In this review, we analyzed the literature discussing the influence of environmental factors (lifestyle factors and pollutants) on PTH and calcitonin levels. Among lifestyle factors, smoking, body mass index (BMI), diet, alcohol, and exercise were analyzed; among pollutants, heavy metals and chemicals were analyzed. Lifestyle factors that showed the clearest association with PTH levels were smoking, BMI, exercise, and micronutrients taken from the diet (vitamin D and calcium). Smoking, vitamin D, and calcium intake led to a decrease in PTH levels, while higher BMI and exercise led to an increase in PTH levels. In terms of pollutants, exposure to cadmium led to a decrease in PTH levels, while exposure to lead increased PTH levels. Several studies have investigated the effect of chemicals on PTH levels in humans. Compared to PTH studies, a smaller number of studies analyzed the influence of environmental factors on calcitonin levels, which gives great variability in results. Only a few studies have analyzed the influence of pollutants on calcitonin levels in humans. The lifestyle factor with the clearest relationship with calcitonin was smoking (smokers had increased calcitonin levels). Given the importance of PTH and calcitonin in maintaining calcium and phosphate homeostasis and bone mineral metabolism, additional studies on the influence of environmental factors that could affect PTH and calcitonin levels are crucial.</description><subject>Animals</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cadmium</subject><subject>Calciferol</subject><subject>Calcitonin</subject><subject>Calcitonin - metabolism</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Calcium homeostasis</subject><subject>Calcium phosphates</subject><subject>Dairy products</subject><subject>Diet</subject><subject>Enzymes</subject><subject>Food</subject><subject>Genetic factors</subject><subject>Heavy metals</subject><subject>Homeostasis</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Life Style</subject><subject>Literature reviews</subject><subject>Micronutrients</subject><subject>Mineral metabolism</subject><subject>Parathyroid</subject><subject>Parathyroid hormone</subject><subject>Parathyroid Hormone - metabolism</subject><subject>Phosphates - metabolism</subject><subject>Phosphorus</subject><subject>Physiology</subject><subject>Pollutants</subject><subject>Proteins</subject><subject>Review</subject><subject>Smoking</subject><subject>Thyroid gland</subject><subject>Vitamin D</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc1LxDAQxYMoft88S8GLB1cnH23SiyDL-oELetBzmLaJm6VNNOku-N9bdZVV5jAD8-PxHo-QIwrnnJdw4eZdYhwogBAbZJcKxkYAhdxcu3fIXkpzAMZZXm6THZ4DKFGoXXI_8UsXg--M77HNrrHuQ0zZ0wz77MpaU_fZI0bsZ-8xuCa7DbEL3mTom2yMbe364J3PpmZp2nRAtiy2yRyu9j55vp48jW9H04ebu_HVdFQLyvqRQYRcobWskhKN4WVuGQjM8yKnqimqulJV0XBKOZfClIwaW4CVEixHOfD75PJb93VRdaapB-sRW_0aXYfxXQd0-u_Hu5l-CUutpBBSikHgdCUQw9vCpF53LtWmbdGbsEiaFVSVMEw5oCf_0HlYRD_E-6IYV0rkA3X2TdUxpBSN_TVDQX-2pNdbGvDj9QC_8E8t_AN6x45s</recordid><startdate>20211221</startdate><enddate>20211221</enddate><creator>Babić Leko, Mirjana</creator><creator>Pleić, Nikolina</creator><creator>Gunjača, Ivana</creator><creator>Zemunik, Tatijana</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7056-6443</orcidid><orcidid>https://orcid.org/0000-0001-5672-871X</orcidid><orcidid>https://orcid.org/0000-0003-4223-4190</orcidid><orcidid>https://orcid.org/0000-0001-8120-2891</orcidid></search><sort><creationdate>20211221</creationdate><title>Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels</title><author>Babić Leko, Mirjana ; Pleić, Nikolina ; Gunjača, Ivana ; Zemunik, Tatijana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-eaa058aff2b77aee395f204a556518d6bcb8b6d3113374e921ef60f770f3a7ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Cadmium</topic><topic>Calciferol</topic><topic>Calcitonin</topic><topic>Calcitonin - metabolism</topic><topic>Calcium</topic><topic>Calcium - metabolism</topic><topic>Calcium homeostasis</topic><topic>Calcium phosphates</topic><topic>Dairy products</topic><topic>Diet</topic><topic>Enzymes</topic><topic>Food</topic><topic>Genetic factors</topic><topic>Heavy metals</topic><topic>Homeostasis</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Life Style</topic><topic>Literature reviews</topic><topic>Micronutrients</topic><topic>Mineral metabolism</topic><topic>Parathyroid</topic><topic>Parathyroid hormone</topic><topic>Parathyroid Hormone - metabolism</topic><topic>Phosphates - metabolism</topic><topic>Phosphorus</topic><topic>Physiology</topic><topic>Pollutants</topic><topic>Proteins</topic><topic>Review</topic><topic>Smoking</topic><topic>Thyroid gland</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babić Leko, Mirjana</creatorcontrib><creatorcontrib>Pleić, Nikolina</creatorcontrib><creatorcontrib>Gunjača, Ivana</creatorcontrib><creatorcontrib>Zemunik, Tatijana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babić Leko, Mirjana</au><au>Pleić, Nikolina</au><au>Gunjača, Ivana</au><au>Zemunik, Tatijana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2021-12-21</date><risdate>2021</risdate><volume>23</volume><issue>1</issue><spage>44</spage><pages>44-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Calciotropic hormones, parathyroid hormone (PTH) and calcitonin are involved in the regulation of bone mineral metabolism and maintenance of calcium and phosphate homeostasis in the body. Therefore, an understanding of environmental and genetic factors influencing PTH and calcitonin levels is crucial. Genetic factors are estimated to account for 60% of variations in PTH levels, while the genetic background of interindividual calcitonin variations has not yet been studied. In this review, we analyzed the literature discussing the influence of environmental factors (lifestyle factors and pollutants) on PTH and calcitonin levels. Among lifestyle factors, smoking, body mass index (BMI), diet, alcohol, and exercise were analyzed; among pollutants, heavy metals and chemicals were analyzed. Lifestyle factors that showed the clearest association with PTH levels were smoking, BMI, exercise, and micronutrients taken from the diet (vitamin D and calcium). Smoking, vitamin D, and calcium intake led to a decrease in PTH levels, while higher BMI and exercise led to an increase in PTH levels. In terms of pollutants, exposure to cadmium led to a decrease in PTH levels, while exposure to lead increased PTH levels. Several studies have investigated the effect of chemicals on PTH levels in humans. Compared to PTH studies, a smaller number of studies analyzed the influence of environmental factors on calcitonin levels, which gives great variability in results. Only a few studies have analyzed the influence of pollutants on calcitonin levels in humans. The lifestyle factor with the clearest relationship with calcitonin was smoking (smokers had increased calcitonin levels). Given the importance of PTH and calcitonin in maintaining calcium and phosphate homeostasis and bone mineral metabolism, additional studies on the influence of environmental factors that could affect PTH and calcitonin levels are crucial.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35008468</pmid><doi>10.3390/ijms23010044</doi><orcidid>https://orcid.org/0000-0002-7056-6443</orcidid><orcidid>https://orcid.org/0000-0001-5672-871X</orcidid><orcidid>https://orcid.org/0000-0003-4223-4190</orcidid><orcidid>https://orcid.org/0000-0001-8120-2891</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2021-12, Vol.23 (1), p.44 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8744774 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Body mass index Body size Cadmium Calciferol Calcitonin Calcitonin - metabolism Calcium Calcium - metabolism Calcium homeostasis Calcium phosphates Dairy products Diet Enzymes Food Genetic factors Heavy metals Homeostasis Homeostasis - physiology Humans Life Style Literature reviews Micronutrients Mineral metabolism Parathyroid Parathyroid hormone Parathyroid Hormone - metabolism Phosphates - metabolism Phosphorus Physiology Pollutants Proteins Review Smoking Thyroid gland Vitamin D |
| title | Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T22%3A34%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Environmental%20Factors%20That%20Affect%20Parathyroid%20Hormone%20and%20Calcitonin%20Levels&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Babi%C4%87%20Leko,%20Mirjana&rft.date=2021-12-21&rft.volume=23&rft.issue=1&rft.spage=44&rft.pages=44-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms23010044&rft_dat=%3Cproquest_pubme%3E2618238845%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2618238845&rft_id=info:pmid/35008468&rfr_iscdi=true |