New Evidence on Regucalcin, Body Composition, and Walking Ability Adaptations to Multicomponent Exercise Training in Functionally Limited and Frail Older Adults
Regucalcin, or senescence marker protein-30 (SMP30), is a Ca -binding protein with multiple functions reported in the literature. Physical exercise has been shown to improve aging markers; nevertheless, SMP30 in humans has not been extensively researched. Older adults experience a decline in functio...
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| Veröffentlicht in: | International journal of environmental research and public health 2021-12, Vol.19 (1), p.363 |
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| creator | Pérez-Gómez, Jorge Redondo, Pedro C Navarrete-Villanueva, David Lozano-Berges, Gabriel Ara, Ignacio González-Gross, Marcela Casajus, José A Vicente-Rodríguez, Germán |
| description | Regucalcin, or senescence marker protein-30 (SMP30), is a Ca
-binding protein with multiple functions reported in the literature. Physical exercise has been shown to improve aging markers; nevertheless, SMP30 in humans has not been extensively researched. Older adults experience a decline in functional capacity and body composition. The purpose of this study was to examine the effects of a multicomponent training (MCT) program on SMP30 and its regulation of walking ability and body composition in functionally limited, frail, and pre-frail older adults.
A total of 34 older adults (aged 80.3 ± 6.1 years) were divided into an intervention group (IG = 20) and control group (CG = 14). The IG performed a supervised MCT (strength, endurance, balance, coordination, and flexibility) program for 6 months, 3 days per week, whereas the CG continued their normal lives without any specific physical training. SMP30 was analyzed in plasma after 3 and 6 months of MCT, while some physical fitness variables (Timed Up and Go (TUG) and 6-min walk test (6MWT)) and body composition (fat mass and lean mass) were measured at baseline, as well as after 3 months and 6 months of MCT.
No significant changes were observed in SPM30 between the IG (877.5 a.u. to 940.5 a.u., respectively) and CG (790.4 a.u. to 763.8 a.u., respectively). Moreover, no SMP30 differences were found between groups after 3 and 6 months of MCT. The IG improved significantly in the 6MWT after 3 months (472.2 ± 84.2 m) compared to baseline (411.2 ± 75.2 m). The IG also significantly enhanced their TUG performance after 3 months (7.6 ± 1.6 s) and 6 months (7.3 ± 1.8 s) of training compared to baseline (9.3 ± 3.2 s) (all,
< 0.001). There were no significant differences in body composition between the IG and CG through the 6 months of MCT.
The present study suggests that MCT did not change SMP30 levels from 3 to 6 months, where there were changes in neither walking ability nor body composition; however, MCT was effective in improving 6MWT and TUG performance from baseline to 3 months. |
| doi_str_mv | 10.3390/ijerph19010363 |
| format | Article |
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-binding protein with multiple functions reported in the literature. Physical exercise has been shown to improve aging markers; nevertheless, SMP30 in humans has not been extensively researched. Older adults experience a decline in functional capacity and body composition. The purpose of this study was to examine the effects of a multicomponent training (MCT) program on SMP30 and its regulation of walking ability and body composition in functionally limited, frail, and pre-frail older adults.
A total of 34 older adults (aged 80.3 ± 6.1 years) were divided into an intervention group (IG = 20) and control group (CG = 14). The IG performed a supervised MCT (strength, endurance, balance, coordination, and flexibility) program for 6 months, 3 days per week, whereas the CG continued their normal lives without any specific physical training. SMP30 was analyzed in plasma after 3 and 6 months of MCT, while some physical fitness variables (Timed Up and Go (TUG) and 6-min walk test (6MWT)) and body composition (fat mass and lean mass) were measured at baseline, as well as after 3 months and 6 months of MCT.
No significant changes were observed in SPM30 between the IG (877.5 a.u. to 940.5 a.u., respectively) and CG (790.4 a.u. to 763.8 a.u., respectively). Moreover, no SMP30 differences were found between groups after 3 and 6 months of MCT. The IG improved significantly in the 6MWT after 3 months (472.2 ± 84.2 m) compared to baseline (411.2 ± 75.2 m). The IG also significantly enhanced their TUG performance after 3 months (7.6 ± 1.6 s) and 6 months (7.3 ± 1.8 s) of training compared to baseline (9.3 ± 3.2 s) (all,
< 0.001). There were no significant differences in body composition between the IG and CG through the 6 months of MCT.
The present study suggests that MCT did not change SMP30 levels from 3 to 6 months, where there were changes in neither walking ability nor body composition; however, MCT was effective in improving 6MWT and TUG performance from baseline to 3 months.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph19010363</identifier><identifier>PMID: 35010623</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adaptation ; Adults ; Aged ; Aging ; Antibodies ; Apoptosis ; Body Composition ; Body fat ; Body mass index ; Calcium ions ; Calcium-binding protein ; Cancer ; Composition effects ; Exercise ; Exercise Therapy ; Frail Elderly ; Frailty ; Gene expression ; Health facilities ; Homeostasis ; Humans ; Immunoglobulins ; Markers ; Older people ; Physical exercise ; Physical Fitness ; Physical training ; Physiology ; Proteins ; Senescence ; Walking ; Working groups</subject><ispartof>International journal of environmental research and public health, 2021-12, Vol.19 (1), p.363</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c373t-7d2fcbfdcb628788d00e146d422489b5f75d56ef31c227011d37cf22b7f03bef3</cites><orcidid>0000-0002-0137-9900 ; 0000-0002-4054-9132 ; 0000-0001-7757-3235 ; 0000-0002-4303-4097 ; 0000-0002-2854-6684 ; 0000-0002-7215-6931 ; 0000-0002-2067-2627</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744755/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744755/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35010623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pérez-Gómez, Jorge</creatorcontrib><creatorcontrib>Redondo, Pedro C</creatorcontrib><creatorcontrib>Navarrete-Villanueva, David</creatorcontrib><creatorcontrib>Lozano-Berges, Gabriel</creatorcontrib><creatorcontrib>Ara, Ignacio</creatorcontrib><creatorcontrib>González-Gross, Marcela</creatorcontrib><creatorcontrib>Casajus, José A</creatorcontrib><creatorcontrib>Vicente-Rodríguez, Germán</creatorcontrib><title>New Evidence on Regucalcin, Body Composition, and Walking Ability Adaptations to Multicomponent Exercise Training in Functionally Limited and Frail Older Adults</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Regucalcin, or senescence marker protein-30 (SMP30), is a Ca
-binding protein with multiple functions reported in the literature. Physical exercise has been shown to improve aging markers; nevertheless, SMP30 in humans has not been extensively researched. Older adults experience a decline in functional capacity and body composition. The purpose of this study was to examine the effects of a multicomponent training (MCT) program on SMP30 and its regulation of walking ability and body composition in functionally limited, frail, and pre-frail older adults.
A total of 34 older adults (aged 80.3 ± 6.1 years) were divided into an intervention group (IG = 20) and control group (CG = 14). The IG performed a supervised MCT (strength, endurance, balance, coordination, and flexibility) program for 6 months, 3 days per week, whereas the CG continued their normal lives without any specific physical training. SMP30 was analyzed in plasma after 3 and 6 months of MCT, while some physical fitness variables (Timed Up and Go (TUG) and 6-min walk test (6MWT)) and body composition (fat mass and lean mass) were measured at baseline, as well as after 3 months and 6 months of MCT.
No significant changes were observed in SPM30 between the IG (877.5 a.u. to 940.5 a.u., respectively) and CG (790.4 a.u. to 763.8 a.u., respectively). Moreover, no SMP30 differences were found between groups after 3 and 6 months of MCT. The IG improved significantly in the 6MWT after 3 months (472.2 ± 84.2 m) compared to baseline (411.2 ± 75.2 m). The IG also significantly enhanced their TUG performance after 3 months (7.6 ± 1.6 s) and 6 months (7.3 ± 1.8 s) of training compared to baseline (9.3 ± 3.2 s) (all,
< 0.001). There were no significant differences in body composition between the IG and CG through the 6 months of MCT.
The present study suggests that MCT did not change SMP30 levels from 3 to 6 months, where there were changes in neither walking ability nor body composition; however, MCT was effective in improving 6MWT and TUG performance from baseline to 3 months.</description><subject>Adaptation</subject><subject>Adults</subject><subject>Aged</subject><subject>Aging</subject><subject>Antibodies</subject><subject>Apoptosis</subject><subject>Body Composition</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Calcium ions</subject><subject>Calcium-binding protein</subject><subject>Cancer</subject><subject>Composition effects</subject><subject>Exercise</subject><subject>Exercise Therapy</subject><subject>Frail Elderly</subject><subject>Frailty</subject><subject>Gene expression</subject><subject>Health facilities</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Markers</subject><subject>Older people</subject><subject>Physical exercise</subject><subject>Physical Fitness</subject><subject>Physical training</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Senescence</subject><subject>Walking</subject><subject>Working groups</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU9vFCEYhydGY2v16tGQePHgVv7MAHMxWTe7arLaxNR4JAwwW1YGRmCq-238qDJubVpPkPd9fk9eeKvqOYLnhLTwjd2bOF6hFiJIKHlQnSJK4aKmED28cz-pnqS0h5DwmraPqxPSFJ5iclr9_mx-gvW11cYrA4IHX8xuUtIp61-Dd0EfwCoMY0g221Aq0mvwTbrv1u_AsrPO5gNYajlmOfcTyAF8mly2ag554zNY_zJR2WTAZZTWzznrwWbyag5I5w5gawebjf7r3hTIgQunTSzeYkpPq0e9dMk8uznPqq-b9eXqw2J78f7jarldKMJIXjCNe9X1WnUUc8a5htCgmuoa45q3XdOzRjfU9AQpjBlESBOmeow71kPSlfpZ9fboHaduMFqV2aN0Yox2kPEggrTifsfbK7EL14KzumZNUwSvbgQx_JhMymKwSRnnpDdhSgJTxFvEOOIFffkfug9TLL9xpDBBhSvU-ZFSMaQUTX87DIJiXr64v_wSeHH3Cbf4v22TP0o7rtc</recordid><startdate>20211230</startdate><enddate>20211230</enddate><creator>Pérez-Gómez, Jorge</creator><creator>Redondo, Pedro C</creator><creator>Navarrete-Villanueva, David</creator><creator>Lozano-Berges, Gabriel</creator><creator>Ara, Ignacio</creator><creator>González-Gross, Marcela</creator><creator>Casajus, José A</creator><creator>Vicente-Rodríguez, Germán</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0137-9900</orcidid><orcidid>https://orcid.org/0000-0002-4054-9132</orcidid><orcidid>https://orcid.org/0000-0001-7757-3235</orcidid><orcidid>https://orcid.org/0000-0002-4303-4097</orcidid><orcidid>https://orcid.org/0000-0002-2854-6684</orcidid><orcidid>https://orcid.org/0000-0002-7215-6931</orcidid><orcidid>https://orcid.org/0000-0002-2067-2627</orcidid></search><sort><creationdate>20211230</creationdate><title>New Evidence on Regucalcin, Body Composition, and Walking Ability Adaptations to Multicomponent Exercise Training in Functionally Limited and Frail Older Adults</title><author>Pérez-Gómez, Jorge ; Redondo, Pedro C ; Navarrete-Villanueva, David ; Lozano-Berges, Gabriel ; Ara, Ignacio ; González-Gross, Marcela ; Casajus, José A ; Vicente-Rodríguez, Germán</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-7d2fcbfdcb628788d00e146d422489b5f75d56ef31c227011d37cf22b7f03bef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adaptation</topic><topic>Adults</topic><topic>Aged</topic><topic>Aging</topic><topic>Antibodies</topic><topic>Apoptosis</topic><topic>Body Composition</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Calcium ions</topic><topic>Calcium-binding protein</topic><topic>Cancer</topic><topic>Composition effects</topic><topic>Exercise</topic><topic>Exercise Therapy</topic><topic>Frail Elderly</topic><topic>Frailty</topic><topic>Gene expression</topic><topic>Health facilities</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Markers</topic><topic>Older people</topic><topic>Physical exercise</topic><topic>Physical Fitness</topic><topic>Physical training</topic><topic>Physiology</topic><topic>Proteins</topic><topic>Senescence</topic><topic>Walking</topic><topic>Working groups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pérez-Gómez, Jorge</creatorcontrib><creatorcontrib>Redondo, Pedro C</creatorcontrib><creatorcontrib>Navarrete-Villanueva, David</creatorcontrib><creatorcontrib>Lozano-Berges, Gabriel</creatorcontrib><creatorcontrib>Ara, Ignacio</creatorcontrib><creatorcontrib>González-Gross, Marcela</creatorcontrib><creatorcontrib>Casajus, José A</creatorcontrib><creatorcontrib>Vicente-Rodríguez, Germán</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pérez-Gómez, Jorge</au><au>Redondo, Pedro C</au><au>Navarrete-Villanueva, David</au><au>Lozano-Berges, Gabriel</au><au>Ara, Ignacio</au><au>González-Gross, Marcela</au><au>Casajus, José A</au><au>Vicente-Rodríguez, Germán</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Evidence on Regucalcin, Body Composition, and Walking Ability Adaptations to Multicomponent Exercise Training in Functionally Limited and Frail Older Adults</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2021-12-30</date><risdate>2021</risdate><volume>19</volume><issue>1</issue><spage>363</spage><pages>363-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Regucalcin, or senescence marker protein-30 (SMP30), is a Ca
-binding protein with multiple functions reported in the literature. Physical exercise has been shown to improve aging markers; nevertheless, SMP30 in humans has not been extensively researched. Older adults experience a decline in functional capacity and body composition. The purpose of this study was to examine the effects of a multicomponent training (MCT) program on SMP30 and its regulation of walking ability and body composition in functionally limited, frail, and pre-frail older adults.
A total of 34 older adults (aged 80.3 ± 6.1 years) were divided into an intervention group (IG = 20) and control group (CG = 14). The IG performed a supervised MCT (strength, endurance, balance, coordination, and flexibility) program for 6 months, 3 days per week, whereas the CG continued their normal lives without any specific physical training. SMP30 was analyzed in plasma after 3 and 6 months of MCT, while some physical fitness variables (Timed Up and Go (TUG) and 6-min walk test (6MWT)) and body composition (fat mass and lean mass) were measured at baseline, as well as after 3 months and 6 months of MCT.
No significant changes were observed in SPM30 between the IG (877.5 a.u. to 940.5 a.u., respectively) and CG (790.4 a.u. to 763.8 a.u., respectively). Moreover, no SMP30 differences were found between groups after 3 and 6 months of MCT. The IG improved significantly in the 6MWT after 3 months (472.2 ± 84.2 m) compared to baseline (411.2 ± 75.2 m). The IG also significantly enhanced their TUG performance after 3 months (7.6 ± 1.6 s) and 6 months (7.3 ± 1.8 s) of training compared to baseline (9.3 ± 3.2 s) (all,
< 0.001). There were no significant differences in body composition between the IG and CG through the 6 months of MCT.
The present study suggests that MCT did not change SMP30 levels from 3 to 6 months, where there were changes in neither walking ability nor body composition; however, MCT was effective in improving 6MWT and TUG performance from baseline to 3 months.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35010623</pmid><doi>10.3390/ijerph19010363</doi><orcidid>https://orcid.org/0000-0002-0137-9900</orcidid><orcidid>https://orcid.org/0000-0002-4054-9132</orcidid><orcidid>https://orcid.org/0000-0001-7757-3235</orcidid><orcidid>https://orcid.org/0000-0002-4303-4097</orcidid><orcidid>https://orcid.org/0000-0002-2854-6684</orcidid><orcidid>https://orcid.org/0000-0002-7215-6931</orcidid><orcidid>https://orcid.org/0000-0002-2067-2627</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation Adults Aged Aging Antibodies Apoptosis Body Composition Body fat Body mass index Calcium ions Calcium-binding protein Cancer Composition effects Exercise Exercise Therapy Frail Elderly Frailty Gene expression Health facilities Homeostasis Humans Immunoglobulins Markers Older people Physical exercise Physical Fitness Physical training Physiology Proteins Senescence Walking Working groups |
| title | New Evidence on Regucalcin, Body Composition, and Walking Ability Adaptations to Multicomponent Exercise Training in Functionally Limited and Frail Older Adults |
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