Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer

Lung cancer is the leading cause of death from cancer in Taiwan and throughout the world. Immunotherapy has revealed promising and significant efficacy in NSCLC, through immune checkpoint inhibition by blocking programmed cell death protein (PD)-1/PD-1 ligand (PD-L1) signaling pathway to restore pat...

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Veröffentlicht in:	International journal of molecular sciences 2021-12, Vol.23 (1), p.64
Hauptverfasser:	Luo, Yung-Hung, Yang, Yi-Ping, Chien, Chian-Shiu, Yarmishyn, Aliaksandr A, Adekunle Ishola, Afeez, Chien, Yueh, Chen, Yuh-Min, Tsai, Ping-Hsing, Lin, Tzu-Wei, Wang, Mong-Lien, Chiou, Shih-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Apoptosis B7-H1 Antigen - genetics Binding sites Biomarkers Biomarkers, Tumor - genetics Biopsy Blood Carcinogenesis - genetics Carcinoma, Non-Small-Cell Lung - genetics Cell activation Cell adhesion & migration Cell death Cell Line, Tumor Circular RNA Down-Regulation - genetics Exosomes Gene expression Humans Immune checkpoint Immune Evasion - genetics Immunopathogenesis Immunotherapy Lung cancer Lung Neoplasms - genetics Lymphocytes T Male Medical prognosis Mice Mice, Inbred BALB C Mice, Nude MicroRNAs mRNA Nanoparticles Non-small cell lung carcinoma PD-1 protein PD-L1 protein RNA, Circular - genetics Saliva Signal transduction T-Lymphocytes - physiology Taiwan Tumorigenesis Tumors Up-Regulation - genetics Wound healing
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