A FZD7-specific Antibody-Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models

Although WNT signaling is frequently dysregulated in solid tumors, drugging this pathway has been challenging due to off-tumor effects. Current clinical pan-WNT inhibitors are nonspecific and lead to adverse effects, highlighting the urgent need for more specific WNT pathway-targeting strategies. We...

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Veröffentlicht in:	Molecular cancer therapeutics 2022-01, Vol.21 (1), p.113-124
Hauptverfasser:	Do, Myan, Wu, Christina C N, Sonavane, Pooja R, Juarez, Edwin F, Adams, Stephen R, Ross, Jason, Rodriguez Y Baena, Alessandra, Patel, Charmi, Mesirov, Jill P, Carson, Dennis A, Advani, Sunil J, Willert, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Proliferation Female Frizzled Receptors - genetics Humans Immunoconjugates - metabolism Mice Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology
Online-Zugang:	Volltext
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