Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia

Hemorrhage is a leading cause of battlefield and civilian trauma deaths. Several pain medications, including fentanyl, are recommended for use in the prehospital (i.e., field setting) for a hemorrhaging solider. However, it is unknown whether fentanyl impairs arterial blood pressure (BP) regulation,...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2022-01, Vol.322 (1), p.R55-R63
Hauptverfasser:	Huang, Mu, Watso, Joseph C, Belval, Luke N, Cimino, Frank A, Fischer, Mads, Jarrard, Caitlin P, Hendrix, Joseph M, Laborde, Carmen Hinojosa, Crandall, Craig G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analgesics Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Battlefields Blood pressure Blood Pressure - drug effects Cardiovascular System - innervation Cross-Over Studies Double-Blind Method Female Fentanyl Fentanyl - administration & dosage Fentanyl - adverse effects Hemorrhage Hemorrhage - diagnosis Hemorrhage - physiopathology Humans Hypovolemia Hypovolemia - diagnosis Hypovolemia - physiopathology Infusions, Intravenous Intravenous administration Lower Body Negative Pressure Male Microneurography Middle Aged Muscle, Skeletal - innervation Muscles Pain Placebos Sympathetic nerves Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiopathology Trauma Young Adult
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