Regulation of lung epithelial cell senescence in smoking-induced COPD/emphysema by microR-125a-5p via Sp1 mediation of SIRT1/HIF-1a

Chronic obstructive pulmonary disease (COPD) affects the health of more than 300 million people worldwide; at present, there is no effective drug to treat COPD. Smoking is the most important risk factor, but the molecular mechanism by which smoking causes the disease is unclear. The senescence of lu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of biological sciences 2022, Vol.18 (2), p.661-674
Hauptverfasser:	Wu, Hao, Ma, Huimin, Wang, Lumin, Zhang, Huazhong, Lu, Lu, Xiao, Tian, Cheng, Cheng, Wang, Peiwen, Yang, Yi, Wu, Meng, Wang, Suhua, Zhang, Jinsong, Liu, Qizhan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adenoviruses Aging Apoptosis Bronchus Cell cycle Chronic obstructive pulmonary disease Cigarette smoke Cigarettes Emphysema Epigenetics Epithelial cells Epithelium Galactose Gene expression Genotype & phenotype Hypoxia-inducible factor 1a Lung diseases Lungs MicroRNAs Obstructive lung disease Pathogenesis Phenotypes Plethysmography Research Paper Respiratory function Risk analysis Risk factors Senescence SIRT1 protein Smoking
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!