BDNF signaling in context: From synaptic regulation to psychiatric disorders
Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important roles in synaptic development and plasticity. While its importance in fundamental physiology is well established, studies of BDNF often produce conflicting and unclear results, and the scope of existing research...
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| Veröffentlicht in: | Cell 2022-01, Vol.185 (1), p.62-76 |
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| creator | Wang, Camille S. Kavalali, Ege T. Monteggia, Lisa M. |
| description | Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important roles in synaptic development and plasticity. While its importance in fundamental physiology is well established, studies of BDNF often produce conflicting and unclear results, and the scope of existing research makes the prospect of setting future directions daunting. In this review, we examine the importance of spatial and temporal factors on BDNF activity, particularly in processes such as synaptogenesis, Hebbian plasticity, homeostatic plasticity, and the treatment of psychiatric disorders. Understanding the fundamental physiology of when, where, and how BDNF acts and new approaches to control BDNF signaling in time and space can contribute to improved therapeutics and patient outcomes.
The pleiotropic and sometimes apparently contradictory functions of brain-derived neurotrophic factor (BDNF) can be resolved through the lens of context. Implications for the development of improved neuropsychiatric treatment and patient outcomes ensue. |
| doi_str_mv | 10.1016/j.cell.2021.12.003 |
| format | Article |
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The pleiotropic and sometimes apparently contradictory functions of brain-derived neurotrophic factor (BDNF) can be resolved through the lens of context. 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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Brain - metabolism Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Homeostasis - physiology Humans Mental Disorders - drug therapy Mental Disorders - genetics Mental Disorders - metabolism Neurogenesis - physiology Neuronal Plasticity - physiology Neuropeptides - genetics Neuropeptides - metabolism Psychotropic Drugs - pharmacology Psychotropic Drugs - therapeutic use Synapses - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology Treatment Outcome |
| title | BDNF signaling in context: From synaptic regulation to psychiatric disorders |
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