SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling

Adult stem cells maintain regenerative tissue structure and function by producing tissue-specific progeny, but the factors that preserve their tissue identities are not well understood. The small and large intestines differ markedly in cell composition and function, reflecting their distinct stem ce...

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Veröffentlicht in:	Cell stem cell 2022-01, Vol.29 (1), p.101-115.e10
Hauptverfasser:	Gu, Wei, Wang, Hua, Huang, Xiaofeng, Kraiczy, Judith, Singh, Pratik N.P., Ng, Charles, Dagdeviren, Sezin, Houghton, Sean, Pellon-Cardenas, Oscar, Lan, Ying, Nie, Yaohui, Zhang, Jiaoyue, Banerjee, Kushal K., Onufer, Emily J., Warner, Brad W., Spence, Jason, Scherl, Ellen, Rafii, Shahin, Lee, Richard T., Verzi, Michael P., Redmond, David, Longman, Randy, Helin, Kristian, Shivdasani, Ramesh A., Zhou, Qiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colon Ileum Intestinal Mucosa Mice Organoids SATB2, intestine regeneration, colonic mucosa, stem cell conversion, enhancer remodelingintestine Stem Cells
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