Structural basis for effector recognition by an antibacterial type IV secretion system

Many soil-, water-, and plant-associated bacterial species from the orders Xanthomonadales, Burkholderales, and Neisseriales carry a type IV secretion system (T4SS) specialized in translocating effector proteins into other gram-negative species, leading to target cell death. These effectors, known a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-01, Vol.119 (1)
Hauptverfasser:	Oka, Gabriel U, Souza, Diorge P, Cenens, William, Matsuyama, Bruno Y, Cardoso, Marcus V C, Oliveira, Luciana C, da Silva Lima, Filipe, Cuccovia, Iolanda M, Guzzo, Cristiane R, Salinas, Roberto K, Farah, Chuck S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Antiinfectives and antibacterials Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - chemistry Bacterial Proteins - genetics Biological Sciences Calorimetry Cell death E coli Escherichia coli - chemistry Escherichia coli - genetics Glutamine Magnetic resonance spectroscopy Models, Molecular Mutation NMR NMR spectroscopy Nuclear magnetic resonance Nuclear Magnetic Resonance, Biomolecular Periplasm Protein Domains Proteins Secretion Soil water Structure-Activity Relationship Titration Titration calorimetry Translocation Type IV Secretion Systems - antagonists & inhibitors Type IV Secretion Systems - chemistry Type IV Secretion Systems - genetics Xanthomonas - chemistry Xanthomonas - genetics Xanthomonas citri
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