HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR

Appended to the 5′ end of nascent RNA polymerase II transcripts is 7-methyl guanosine (m⁷G-cap) that engages nuclear cap-binding complex (CBC) to facilitate messenger RNA (mRNA) maturation. Mature mRNAs exchange CBC for eIF4E, the rate-limiting translation factor that is controlled through mTOR. Exp...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-01, Vol.119 (1), p.1-9
Hauptverfasser:	Singh, Gatikrushna, Seufzer, Bradley, Song, Zhenwei, Zucko, Dora, Heng, Xiao, Boris-Lawrie, Kathleen
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Binding Sites Biological Sciences DEAD-box RNA Helicases DNA helicase DNA-directed RNA polymerase Eukaryotic Initiation Factor-4E - metabolism Guanosine - analogs & derivatives Guanosine - metabolism Guanosines HIV HIV-1 - metabolism Host Microbial Interactions - physiology Human immunodeficiency virus Humans Immune system Infectivity Initiation factor eIF-4E Licensure Methylation Methyltransferases - metabolism Nef protein Neoplasm Proteins Protein biosynthesis Protein synthesis Proteins Regulatory proteins RNA Caps RNA helicase RNA polymerase RNA polymerase II RNA, Messenger - metabolism RNA, Viral - genetics Segments Tat protein TOR protein TOR Serine-Threonine Kinases - metabolism Trimethylguanosine Virion - metabolism Virions
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