Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy
Abstract The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite...
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| Veröffentlicht in: | Case Reports in Oncology 2021-11, Vol.14 (3), p.1725-1732 |
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| creator | Kiso, Sayaka Sugiura, Hiroyuki Kuroi, Taiga Omote, Rika Toji, Tomohiro Ishikawa, Tatsunori Okamoto, Sachiyo Nomura, Naho Masunari, Taro Sezaki, Nobuo Kiguchi, Toru Tanimoto, Mitsune |
| description | Abstract
The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficult during the patient’s lifetime because of the atypical phenotype. However, autopsy revealed that the patient’s bone marrow, liver, and spleen were filled with myeloblasts. In addition, p53 stain and PCR of IgH rearrangement using the autopsy specimen suggested that CLL and AML might be different clones. In conclusion, our case highlights the importance of considering synchronous complications of AML in CLL patients, particularly in those with an atypical clinical course. |
| doi_str_mv | 10.1159/000520427 |
| format | Article |
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The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficult during the patient’s lifetime because of the atypical phenotype. However, autopsy revealed that the patient’s bone marrow, liver, and spleen were filled with myeloblasts. In addition, p53 stain and PCR of IgH rearrangement using the autopsy specimen suggested that CLL and AML might be different clones. In conclusion, our case highlights the importance of considering synchronous complications of AML in CLL patients, particularly in those with an atypical clinical course.</description><identifier>ISSN: 1662-6575</identifier><identifier>EISSN: 1662-6575</identifier><identifier>DOI: 10.1159/000520427</identifier><identifier>PMID: 35082632</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>acute myeloid leukemia ; Analysis ; Autopsies ; Autopsy ; Bone marrow ; Care and treatment ; Case Report ; Case reports ; Chronic lymphocytic leukemia ; Cloning ; Complications and side effects ; Diagnosis ; Flow cytometry ; Genotype & phenotype ; immunohistochemical staining ; Laboratories ; Leukemia ; Liver ; Lymphocytes ; Patients ; Spleen ; Stains & staining ; Tomography</subject><ispartof>Case Reports in Oncology, 2021-11, Vol.14 (3), p.1725-1732</ispartof><rights>2021 The Author(s). Published by S. Karger AG, Basel</rights><rights>Copyright © 2021 by S. Karger AG, Basel.</rights><rights>COPYRIGHT 2021 S. Karger AG</rights><rights>2021 The Author(s). Published by S. Karger AG, Basel . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><rights>Copyright © 2021 by S. Karger AG, Basel 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-5251520dd4fc5afb65790598002d6a74aaa7ce67caee573f134b45f10fab09de3</citedby><orcidid>0000-0003-2322-4798 ; 0000-0001-6542-2376 ; 0000-0002-0453-5657</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740142/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740142/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27635,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35082632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiso, Sayaka</creatorcontrib><creatorcontrib>Sugiura, Hiroyuki</creatorcontrib><creatorcontrib>Kuroi, Taiga</creatorcontrib><creatorcontrib>Omote, Rika</creatorcontrib><creatorcontrib>Toji, Tomohiro</creatorcontrib><creatorcontrib>Ishikawa, Tatsunori</creatorcontrib><creatorcontrib>Okamoto, Sachiyo</creatorcontrib><creatorcontrib>Nomura, Naho</creatorcontrib><creatorcontrib>Masunari, Taro</creatorcontrib><creatorcontrib>Sezaki, Nobuo</creatorcontrib><creatorcontrib>Kiguchi, Toru</creatorcontrib><creatorcontrib>Tanimoto, Mitsune</creatorcontrib><title>Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy</title><title>Case Reports in Oncology</title><addtitle>Case Rep Oncol</addtitle><description>Abstract
The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficult during the patient’s lifetime because of the atypical phenotype. However, autopsy revealed that the patient’s bone marrow, liver, and spleen were filled with myeloblasts. In addition, p53 stain and PCR of IgH rearrangement using the autopsy specimen suggested that CLL and AML might be different clones. In conclusion, our case highlights the importance of considering synchronous complications of AML in CLL patients, particularly in those with an atypical clinical course.</description><subject>acute myeloid leukemia</subject><subject>Analysis</subject><subject>Autopsies</subject><subject>Autopsy</subject><subject>Bone marrow</subject><subject>Care and treatment</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Chronic lymphocytic leukemia</subject><subject>Cloning</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Flow cytometry</subject><subject>Genotype & phenotype</subject><subject>immunohistochemical staining</subject><subject>Laboratories</subject><subject>Leukemia</subject><subject>Liver</subject><subject>Lymphocytes</subject><subject>Patients</subject><subject>Spleen</subject><subject>Stains & staining</subject><subject>Tomography</subject><issn>1662-6575</issn><issn>1662-6575</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhiMEoqVw4I6QpZ44bPFHbCcXpCgqUGnRogrOlmOPd7PN2sFJKuXf4yVlaSXkg-2Zdx77HU2WvSX4ihBefsQYc4pzKp9l50QIuhJc8uePzmfZq2HYYyxKLvjL7IxxXFDB6HkW6-DNFCP4EW38ACMKDtW7GHxr0Ho-9Ltg5vF4hukODq1G2ltUjXPfGt2h7zvwIV0AVWYaAX2boQut_ae-hXvQHVjUzKiaxtAP8-vshdPdAG8e9ovs5-frH_XX1Xrz5aau1ivDOR1XnHKSXFmbO8O1a5KPEvOywJhaoWWutZYGhDQagEvmCMubnDuCnW5waYFdZDcL1wa9V31sDzrOKuhW_QmEuFU6JmsdqJIQIxKyMVLmTpKCYWyanIEjmrCCJdanhdVPzQGsSe2KunsCfZrx7U5tw70qZI5JThPg8gEQw68JhlHtwxR98q-oIKIsOJHHZ64W1Tb1TLXehQQzadnUTBM8uDbFK1EUUkoqSSr4sBSYGIYhgjt9iWB1nA11mo2kff_Yw0n5dxiS4N0iuNNxC_EkONVf_jdd324WheqtY78B8DnJng</recordid><startdate>20211130</startdate><enddate>20211130</enddate><creator>Kiso, Sayaka</creator><creator>Sugiura, Hiroyuki</creator><creator>Kuroi, Taiga</creator><creator>Omote, Rika</creator><creator>Toji, Tomohiro</creator><creator>Ishikawa, Tatsunori</creator><creator>Okamoto, Sachiyo</creator><creator>Nomura, Naho</creator><creator>Masunari, Taro</creator><creator>Sezaki, Nobuo</creator><creator>Kiguchi, Toru</creator><creator>Tanimoto, Mitsune</creator><general>S. 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The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficult during the patient’s lifetime because of the atypical phenotype. However, autopsy revealed that the patient’s bone marrow, liver, and spleen were filled with myeloblasts. In addition, p53 stain and PCR of IgH rearrangement using the autopsy specimen suggested that CLL and AML might be different clones. In conclusion, our case highlights the importance of considering synchronous complications of AML in CLL patients, particularly in those with an atypical clinical course.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>35082632</pmid><doi>10.1159/000520427</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2322-4798</orcidid><orcidid>https://orcid.org/0000-0001-6542-2376</orcidid><orcidid>https://orcid.org/0000-0002-0453-5657</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Karger Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | acute myeloid leukemia Analysis Autopsies Autopsy Bone marrow Care and treatment Case Report Case reports Chronic lymphocytic leukemia Cloning Complications and side effects Diagnosis Flow cytometry Genotype & phenotype immunohistochemical staining Laboratories Leukemia Liver Lymphocytes Patients Spleen Stains & staining Tomography |
| title | Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy |
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