Gestational Weight Gain Influences the Adipokine-Oxidative Stress Association during Pregnancy
Introduction and Objective: The weight gained during pregnancy could determine the immediate and future health of the mother-child dyad. Excessive gestational weight gain (EGWG) due to abnormal adipose tissue (AT) accumulation is strongly associated with adverse perinatal outcomes as gestational dia...
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| Veröffentlicht in: | Obesity Facts 2021-12, Vol.14 (6), p.604-612 |
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| creator | Solis Paredes, Juan Mario Perichart Perera, Otilia Montoya Estrada, Araceli Reyes Muñoz, Enrique Espino y Sosa, Salvador Ortega Castillo, Veronica Medina Bastidas, Diana Tolentino Dolores, Maricruz Sanchez Martinez, Maribel Nava Salazar, Sonia Estrada Gutierrez, Guadalupe |
| description | Introduction and Objective: The weight gained during pregnancy could determine the immediate and future health of the mother-child dyad. Excessive gestational weight gain (EGWG) due to abnormal adipose tissue (AT) accumulation is strongly associated with adverse perinatal outcomes as gestational diabetes, macrosomia, obesity, and hypertension further in life. Dysregulation of adipokine, AT dysfunction, and an imbalance in the prooxidant-antioxidant systems are critical features in altered AT accumulation. This study was aimed to investigate the association between adipokines and oxidative stress markers in pregnant women and the influence of the GWG on this association. Methods: Maternal blood samples were obtained in the third trimester of pregnancy (n = 74) and serum adipokines (adiponectin, leptin, and resistin), oxidative damage markers: 8-oxo-2′-deoxyguanosine (8-oxodG), lipohydroperoxides (LOOH), malondialdehyde (MDA), and carbonylated proteins (CP), and glucose a metabolic marker were measured. Results: Women with EGWG had low adiponectin levels than women with adequate weight gain (AWG) or insufficient weight gain (IWG). Multiple linear regression models revealed a positive association between adiponectin and 8-oxodG in women with AWG (B = 1.09, 95% CI: 164–222, p = 0.027) and IWG (B = 0.860, 95% CI: 0.199–1.52, p = 0.013) but not in women with EGWG. In women with EGWG, leptin was positively associated with LOOH (p = 0.018), MDA (p = 0.005), and CP (p = 0.010) oxidative markers. Conclusion: Our findings suggest that concurrent mechanisms regulate adipokine production and oxidative stress in pregnant women and that this regulation is influenced by GWG, probably due to an excessive AT accumulation. |
| doi_str_mv | 10.1159/000518639 |
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Excessive gestational weight gain (EGWG) due to abnormal adipose tissue (AT) accumulation is strongly associated with adverse perinatal outcomes as gestational diabetes, macrosomia, obesity, and hypertension further in life. Dysregulation of adipokine, AT dysfunction, and an imbalance in the prooxidant-antioxidant systems are critical features in altered AT accumulation. This study was aimed to investigate the association between adipokines and oxidative stress markers in pregnant women and the influence of the GWG on this association. Methods: Maternal blood samples were obtained in the third trimester of pregnancy (n = 74) and serum adipokines (adiponectin, leptin, and resistin), oxidative damage markers: 8-oxo-2′-deoxyguanosine (8-oxodG), lipohydroperoxides (LOOH), malondialdehyde (MDA), and carbonylated proteins (CP), and glucose a metabolic marker were measured. Results: Women with EGWG had low adiponectin levels than women with adequate weight gain (AWG) or insufficient weight gain (IWG). Multiple linear regression models revealed a positive association between adiponectin and 8-oxodG in women with AWG (B = 1.09, 95% CI: 164–222, p = 0.027) and IWG (B = 0.860, 95% CI: 0.199–1.52, p = 0.013) but not in women with EGWG. In women with EGWG, leptin was positively associated with LOOH (p = 0.018), MDA (p = 0.005), and CP (p = 0.010) oxidative markers. Conclusion: Our findings suggest that concurrent mechanisms regulate adipokine production and oxidative stress in pregnant women and that this regulation is influenced by GWG, probably due to an excessive AT accumulation.</description><identifier>ISSN: 1662-4025</identifier><identifier>EISSN: 1662-4033</identifier><identifier>DOI: 10.1159/000518639</identifier><identifier>PMID: 34535612</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adipokines ; Biomarkers ; Body Mass Index ; Chronic illnesses ; Diabetes ; Female ; Fetal Macrosomia ; Gestational age ; Gestational Weight Gain ; Health aspects ; Humans ; Metabolism ; Mother and infant ; Obesity ; Overweight ; Oxidative Stress ; Physiological aspects ; Physiology ; Pregnancy ; Pregnancy Outcome ; Pregnancy, Complications of ; Regression analysis ; Research Article ; Risk factors ; Weight gain ; Womens health</subject><ispartof>Obesity Facts, 2021-12, Vol.14 (6), p.604-612</ispartof><rights>2021 The Author(s). Published by S. Karger AG, Basel</rights><rights>2021 The Author(s). Published by S. Karger AG, Basel.</rights><rights>COPYRIGHT 2021 S. Karger AG</rights><rights>2021 The Author(s). Published by S. Karger AG, Basel . This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2021 by S. Karger AG, Basel 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-940b1e8ef65256385721a755cf5d2382eeb30c864d215682037f0431a0222b823</citedby><cites>FETCH-LOGICAL-c585t-940b1e8ef65256385721a755cf5d2382eeb30c864d215682037f0431a0222b823</cites><orcidid>0000-0003-4529-8296</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740011/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740011/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,27634,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34535612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Solis Paredes, Juan Mario</creatorcontrib><creatorcontrib>Perichart Perera, Otilia</creatorcontrib><creatorcontrib>Montoya Estrada, Araceli</creatorcontrib><creatorcontrib>Reyes Muñoz, Enrique</creatorcontrib><creatorcontrib>Espino y Sosa, Salvador</creatorcontrib><creatorcontrib>Ortega Castillo, Veronica</creatorcontrib><creatorcontrib>Medina Bastidas, Diana</creatorcontrib><creatorcontrib>Tolentino Dolores, Maricruz</creatorcontrib><creatorcontrib>Sanchez Martinez, Maribel</creatorcontrib><creatorcontrib>Nava Salazar, Sonia</creatorcontrib><creatorcontrib>Estrada Gutierrez, Guadalupe</creatorcontrib><title>Gestational Weight Gain Influences the Adipokine-Oxidative Stress Association during Pregnancy</title><title>Obesity Facts</title><addtitle>Obes Facts</addtitle><description>Introduction and Objective: The weight gained during pregnancy could determine the immediate and future health of the mother-child dyad. Excessive gestational weight gain (EGWG) due to abnormal adipose tissue (AT) accumulation is strongly associated with adverse perinatal outcomes as gestational diabetes, macrosomia, obesity, and hypertension further in life. Dysregulation of adipokine, AT dysfunction, and an imbalance in the prooxidant-antioxidant systems are critical features in altered AT accumulation. This study was aimed to investigate the association between adipokines and oxidative stress markers in pregnant women and the influence of the GWG on this association. Methods: Maternal blood samples were obtained in the third trimester of pregnancy (n = 74) and serum adipokines (adiponectin, leptin, and resistin), oxidative damage markers: 8-oxo-2′-deoxyguanosine (8-oxodG), lipohydroperoxides (LOOH), malondialdehyde (MDA), and carbonylated proteins (CP), and glucose a metabolic marker were measured. Results: Women with EGWG had low adiponectin levels than women with adequate weight gain (AWG) or insufficient weight gain (IWG). Multiple linear regression models revealed a positive association between adiponectin and 8-oxodG in women with AWG (B = 1.09, 95% CI: 164–222, p = 0.027) and IWG (B = 0.860, 95% CI: 0.199–1.52, p = 0.013) but not in women with EGWG. In women with EGWG, leptin was positively associated with LOOH (p = 0.018), MDA (p = 0.005), and CP (p = 0.010) oxidative markers. Conclusion: Our findings suggest that concurrent mechanisms regulate adipokine production and oxidative stress in pregnant women and that this regulation is influenced by GWG, probably due to an excessive AT accumulation.</description><subject>Adipokines</subject><subject>Biomarkers</subject><subject>Body Mass Index</subject><subject>Chronic illnesses</subject><subject>Diabetes</subject><subject>Female</subject><subject>Fetal Macrosomia</subject><subject>Gestational age</subject><subject>Gestational Weight Gain</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Metabolism</subject><subject>Mother and infant</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Oxidative Stress</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy, Complications of</subject><subject>Regression analysis</subject><subject>Research Article</subject><subject>Risk factors</subject><subject>Weight gain</subject><subject>Womens health</subject><issn>1662-4025</issn><issn>1662-4033</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>DOA</sourceid><recordid>eNptks9v0zAUgCMEYmNw4I5QJC5w6Hj-meSCFE2sVJpUJEDcsBznJXWX2p2dTOy_x2tLYQj5YMv-_Pm955dlLwmcEyKq9wAgSClZ9Sg7JVLSGQfGHh_XVJxkz2JcA0jCC_I0O2FcMCEJPc1-zDGOerTe6SH_jrZfjflcW5cvXDdM6AzGfFxhXrd266-tw9nyp23ThVvMv4wBY8zrGL2xO0feTsG6Pv8csHfambvn2ZNODxFfHOaz7Nvlx68Xn2ZXy_nior6aGVGKcVZxaAiW2ElBhWSlKCjRhRCmEy1lJUVsGJhS8pYSIUsKrOiAM6KBUtqUlJ1li7239XqttsFudLhTXlu12_ChVzqM1gyoGAXaAml4JxnXDW1IU0lpkAGYjhqZXB_2ru3UbLA16MaghwfShyfOrlTvb1VZcABCkuDtQRD8zZTqqzY2GhwG7dBPUVFRcA6ipFVC3_yDrv0U0l8kqgJgtKDsPrvzPdXrlIB1nU_vmjRa3FjjHXY27dcFEcCLaleOd_sLJvgYA3bH6Amo-5ZRx5ZJ7Ou_0z2Sv3vkT4zXOvQYjsDyst4r1LbtEvXqv9ThlV9Btc6t</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Solis Paredes, Juan Mario</creator><creator>Perichart Perera, Otilia</creator><creator>Montoya Estrada, Araceli</creator><creator>Reyes Muñoz, Enrique</creator><creator>Espino y Sosa, Salvador</creator><creator>Ortega Castillo, Veronica</creator><creator>Medina Bastidas, Diana</creator><creator>Tolentino Dolores, Maricruz</creator><creator>Sanchez Martinez, Maribel</creator><creator>Nava Salazar, Sonia</creator><creator>Estrada Gutierrez, Guadalupe</creator><general>S. 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Weight Gain Influences the Adipokine-Oxidative Stress Association during Pregnancy</title><author>Solis Paredes, Juan Mario ; Perichart Perera, Otilia ; Montoya Estrada, Araceli ; Reyes Muñoz, Enrique ; Espino y Sosa, Salvador ; Ortega Castillo, Veronica ; Medina Bastidas, Diana ; Tolentino Dolores, Maricruz ; Sanchez Martinez, Maribel ; Nava Salazar, Sonia ; Estrada Gutierrez, Guadalupe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-940b1e8ef65256385721a755cf5d2382eeb30c864d215682037f0431a0222b823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipokines</topic><topic>Biomarkers</topic><topic>Body Mass Index</topic><topic>Chronic illnesses</topic><topic>Diabetes</topic><topic>Female</topic><topic>Fetal Macrosomia</topic><topic>Gestational age</topic><topic>Gestational Weight Gain</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Metabolism</topic><topic>Mother and infant</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Oxidative Stress</topic><topic>Physiological aspects</topic><topic>Physiology</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy, Complications of</topic><topic>Regression analysis</topic><topic>Research Article</topic><topic>Risk factors</topic><topic>Weight gain</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solis Paredes, Juan Mario</creatorcontrib><creatorcontrib>Perichart Perera, Otilia</creatorcontrib><creatorcontrib>Montoya Estrada, Araceli</creatorcontrib><creatorcontrib>Reyes Muñoz, Enrique</creatorcontrib><creatorcontrib>Espino y Sosa, Salvador</creatorcontrib><creatorcontrib>Ortega Castillo, Veronica</creatorcontrib><creatorcontrib>Medina Bastidas, Diana</creatorcontrib><creatorcontrib>Tolentino Dolores, 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Journals</collection><jtitle>Obesity Facts</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solis Paredes, Juan Mario</au><au>Perichart Perera, Otilia</au><au>Montoya Estrada, Araceli</au><au>Reyes Muñoz, Enrique</au><au>Espino y Sosa, Salvador</au><au>Ortega Castillo, Veronica</au><au>Medina Bastidas, Diana</au><au>Tolentino Dolores, Maricruz</au><au>Sanchez Martinez, Maribel</au><au>Nava Salazar, Sonia</au><au>Estrada Gutierrez, Guadalupe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gestational Weight Gain Influences the Adipokine-Oxidative Stress Association during Pregnancy</atitle><jtitle>Obesity Facts</jtitle><addtitle>Obes Facts</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>14</volume><issue>6</issue><spage>604</spage><epage>612</epage><pages>604-612</pages><issn>1662-4025</issn><eissn>1662-4033</eissn><abstract>Introduction and Objective: The weight gained during pregnancy could determine the immediate and future health of the mother-child dyad. Excessive gestational weight gain (EGWG) due to abnormal adipose tissue (AT) accumulation is strongly associated with adverse perinatal outcomes as gestational diabetes, macrosomia, obesity, and hypertension further in life. Dysregulation of adipokine, AT dysfunction, and an imbalance in the prooxidant-antioxidant systems are critical features in altered AT accumulation. This study was aimed to investigate the association between adipokines and oxidative stress markers in pregnant women and the influence of the GWG on this association. Methods: Maternal blood samples were obtained in the third trimester of pregnancy (n = 74) and serum adipokines (adiponectin, leptin, and resistin), oxidative damage markers: 8-oxo-2′-deoxyguanosine (8-oxodG), lipohydroperoxides (LOOH), malondialdehyde (MDA), and carbonylated proteins (CP), and glucose a metabolic marker were measured. Results: Women with EGWG had low adiponectin levels than women with adequate weight gain (AWG) or insufficient weight gain (IWG). Multiple linear regression models revealed a positive association between adiponectin and 8-oxodG in women with AWG (B = 1.09, 95% CI: 164–222, p = 0.027) and IWG (B = 0.860, 95% CI: 0.199–1.52, p = 0.013) but not in women with EGWG. In women with EGWG, leptin was positively associated with LOOH (p = 0.018), MDA (p = 0.005), and CP (p = 0.010) oxidative markers. Conclusion: Our findings suggest that concurrent mechanisms regulate adipokine production and oxidative stress in pregnant women and that this regulation is influenced by GWG, probably due to an excessive AT accumulation.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>34535612</pmid><doi>10.1159/000518639</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4529-8296</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipokines Biomarkers Body Mass Index Chronic illnesses Diabetes Female Fetal Macrosomia Gestational age Gestational Weight Gain Health aspects Humans Metabolism Mother and infant Obesity Overweight Oxidative Stress Physiological aspects Physiology Pregnancy Pregnancy Outcome Pregnancy, Complications of Regression analysis Research Article Risk factors Weight gain Womens health |
| title | Gestational Weight Gain Influences the Adipokine-Oxidative Stress Association during Pregnancy |
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