Lipopolysaccharide-Induced Transcriptional Changes in LBP-Deficient Rat and Its Possible Implications for Liver Dysregulation during Sepsis

Sepsis is an organ dysfunction caused by the dysregulated inflammatory response to infection. Lipopolysaccharide-binding protein (LBP) binds to lipopolysaccharide (LPS) and modulates the inflammatory response. A rare systematic study has been reported to detect the effect of LBP gene during LPS-indu...

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Veröffentlicht in:	Journal of immunology research 2021-12, Vol.2021, p.8356645-14, Article 8356645
Hauptverfasser:	He, Zhixiang, Song, Zichen, Meng, Leilei, Cheng, Wenhui, Huang, Fan, Zheng, Mao, Xu, Wenhui, Xiao, Rong, Fang, Haoshu, Zhu, Yaling
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - genetics Acute-Phase Proteins - metabolism Alkaline phosphatase Animals Bioinformatics Carrier Proteins - genetics Carrier Proteins - metabolism Caspase-3 Cluster analysis CXCL10 protein Dehydrogenases Gene expression Gene Expression Regulation Gene Knockout Techniques Genomes HMGB1 protein Humans Immunohistochemistry Immunology Inflammation Inflammation - genetics L-Lactate dehydrogenase Laboratory animals Lactic acid Life Sciences & Biomedicine Lipid metabolism Lipid Metabolism - genetics Lipopolysaccharide-binding protein Lipopolysaccharides Lipopolysaccharides - immunology Lipoproteins Liver Liver - physiology Liver Diseases - genetics Liver Diseases - immunology LRP5 protein Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism NF-κB protein Ontology Pathogenesis Peroxisome proliferator-activated receptors Rats Rats, Sprague-Dawley RNA Interference Science & Technology Sepsis Sepsis - genetics Sepsis - immunology Signal transduction Transcription Transcriptomics Values
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